Attentin
Generic Name
Dexamfetamine
Manufacturer
Takeda Pharmaceuticals
Country
United Kingdom / European Union
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| attentin 40 mg capsule | ৳ 35.00 | ৳ 350.00 |
Description
Overview of the medicine
Attentin is an extended-release capsule containing dexamfetamine, a central nervous system (CNS) stimulant. It is used in the treatment of Attention Deficit Hyperactivity Disorder (ADHD).
Uses & Indications
Dosage
Adults
Individualized, typically initiated at 10-20 mg once daily in the morning, gradually titrated to a maximum of 40 mg once daily based on response and tolerability.
Elderly
Use with caution; lower initial doses and slower titration may be required due to potential for increased sensitivity and co-morbidities.
Renal_impairment
Use with caution. Dosage adjustment may be necessary in severe renal impairment, monitor for adverse effects.
How to Take
Administer orally, usually once daily in the morning, with or without food. Capsules should be swallowed whole with water; do not crush, chew, or open the capsule.
Mechanism of Action
Increases the release of noradrenaline and dopamine from nerve terminals in the brain and blocks their reuptake, leading to increased levels of these neurotransmitters in the synaptic cleft.
Pharmacokinetics
Onset
Typically within 30-60 minutes for initial release, with sustained action over several hours (e.g., 8-12 hours).
Excretion
Excreted mainly by the kidneys, with excretion rate dependent on urinary pH.
Half life
Approximately 10-13 hours.
Absorption
Rapidly absorbed after oral administration. Extended-release formulation provides a biphasic release profile.
Metabolism
Primarily metabolized in the liver via CYP2D6 and other enzymes.
Side Effects
Contraindications
- •Hypersensitivity to amphetamines or excipients
- •Advanced arteriosclerosis
- •Symptomatic cardiovascular disease
- •Moderate to severe hypertension
- •Hyperthyroidism
- •Glaucoma
- •Agitated states
- •History of drug abuse
- •During or within 14 days following MAOI administration
Drug Interactions
MAOIs
Concomitant use is contraindicated; risk of hypertensive crisis.
Antihypertensives
May reduce the hypotensive effect of these drugs.
Tricyclic antidepressants
Increased cardiovascular effects of dexamfetamine.
Urinary acidifiers/alkalinizers
Can alter the excretion rate of dexamfetamine, affecting its duration of action.
Storage
Store below 25°C in a dry place. Protect from light and moisture. Keep out of sight and reach of children.
Overdose
Symptoms include restlessness, tremor, hyperreflexia, rapid respiration, confusion, hallucinations, panic states, hyperpyrexia, rhabdomyolysis, convulsions, coma. Management is symptomatic and supportive, potentially involving gastric lavage, activated charcoal, and urine acidification to enhance excretion.
Pregnancy & Lactation
Generally not recommended during pregnancy unless the potential benefit justifies the potential risk to the fetus. Avoid during lactation as it is excreted in breast milk and may cause adverse effects in the infant.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years; refer to the expiry date on the packaging.
Availability
Pharmacies (Europe/UK)
Approval Status
Approved by regulatory authorities (e.g., MHRA)
Patent Status
Active ingredient generally off-patent, but specific formulation/brand may have patents.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine
More Medicines
Explore other medicines you might be interested in
