Av
Generic Name
Atorvastatin 10 mg tablet
Manufacturer
Hypothetical Pharma Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| av 10 mg tablet | ৳ 13.00 | ৳ 130.00 |
Description
Overview of the medicine
Atorvastatin is a lipid-lowering medication. It belongs to the class of drugs called statins. It works by reducing the production of cholesterol in the liver. It is used to lower 'bad' cholesterol (LDL) and triglycerides and raise 'good' cholesterol (HDL) in the blood. It helps reduce the risk of heart disease and stroke.
Uses & Indications
Dosage
Adults
Initial dose is usually 10 mg or 20 mg once daily. Dose may be adjusted according to LDL-C goals, up to a maximum of 80 mg once daily. For primary hypercholesterolemia, 10 mg once daily is a common starting dose.
Elderly
No dose adjustment generally required.
Renal_impairment
No dose adjustment required.
How to Take
Av 10 mg tablet should be taken orally, once daily, with or without food. It can be taken at any time of the day, but it is recommended to take it at the same time each day to maintain consistent blood levels. Do not crush, chew, or break the tablet; swallow it whole.
Mechanism of Action
Atorvastatin selectively inhibits HMG-CoA reductase, an enzyme that catalyzes the rate-limiting step in cholesterol biosynthesis (conversion of HMG-CoA to mevalonate). This inhibition leads to a decrease in hepatic cholesterol synthesis, which in turn upregulates LDL receptors on hepatocyte membranes, increasing LDL uptake and catabolism. It also reduces very low-density lipoprotein (VLDL) and triglyceride levels.
Pharmacokinetics
Onset
Lipid-lowering effects observed within 2 weeks, maximum effect by 4 weeks.
Excretion
Primarily excreted in bile following hepatic and/or extrahepatic metabolism. Less than 2% of a dose is recovered in urine.
Half life
Elimination half-life of parent drug is approximately 14 hours; active metabolites contribute to plasma HMG-CoA reductase inhibitory activity of 20-30 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract; peak plasma concentrations reached within 1-2 hours. Absolute bioavailability is approximately 14% due to extensive first-pass metabolism.
Metabolism
Extensively metabolized by cytochrome P450 3A4 (CYP3A4) to ortho- and parahydroxylated derivatives and various beta-oxidation products.
Side Effects
Contraindications
- Active liver disease or unexplained persistent elevations of serum transaminases.
- Pregnancy and lactation.
- Hypersensitivity to atorvastatin or any component of the medication.
Drug Interactions
Colestipol
Decreased plasma concentrations of atorvastatin. Administer atorvastatin at least 1 hour before or 4 hours after colestipol.
Grapefruit juice
May increase plasma concentrations of atorvastatin. Avoid large quantities.
Oral contraceptives
May increase plasma concentrations of ethinyl estradiol and norethindrone.
Coumarin derivatives (e.g., warfarin)
May increase INR. Monitor INR carefully.
Gemfibrozil, other fibrates, niacin (lipid-modifying doses)
Increased risk of myopathy. Use with caution.
Cyclosporine, telaprevir, glecaprevir/pibrentasvir, tipranavir/ritonavir
Greatly increased risk of myopathy/rhabdomyolysis. Avoid co-administration.
Clarithromycin, erythromycin, diltiazem, amiodarone, verapamil, azole antifungals (e.g., itraconazole, ketoconazole)
Increased plasma concentrations of atorvastatin. Limit atorvastatin dose.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
There is no specific treatment for atorvastatin overdose. In the event of an overdose, the patient should be treated symptomatically, and supportive measures instituted as required. Due to extensive drug binding to plasma proteins, hemodialysis is not expected to significantly enhance atorvastatin clearance.
Pregnancy & Lactation
Atorvastatin is contraindicated during pregnancy and breastfeeding. It can cause fetal harm when administered to pregnant women. Women of childbearing potential should use adequate contraception during treatment. It is unknown whether atorvastatin or its metabolites are excreted in human milk; however, because of the potential for serious adverse reactions in nursing infants, women taking atorvastatin should not breastfeed.
Side Effects
Contraindications
- Active liver disease or unexplained persistent elevations of serum transaminases.
- Pregnancy and lactation.
- Hypersensitivity to atorvastatin or any component of the medication.
Drug Interactions
Colestipol
Decreased plasma concentrations of atorvastatin. Administer atorvastatin at least 1 hour before or 4 hours after colestipol.
Grapefruit juice
May increase plasma concentrations of atorvastatin. Avoid large quantities.
Oral contraceptives
May increase plasma concentrations of ethinyl estradiol and norethindrone.
Coumarin derivatives (e.g., warfarin)
May increase INR. Monitor INR carefully.
Gemfibrozil, other fibrates, niacin (lipid-modifying doses)
Increased risk of myopathy. Use with caution.
Cyclosporine, telaprevir, glecaprevir/pibrentasvir, tipranavir/ritonavir
Greatly increased risk of myopathy/rhabdomyolysis. Avoid co-administration.
Clarithromycin, erythromycin, diltiazem, amiodarone, verapamil, azole antifungals (e.g., itraconazole, ketoconazole)
Increased plasma concentrations of atorvastatin. Limit atorvastatin dose.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
There is no specific treatment for atorvastatin overdose. In the event of an overdose, the patient should be treated symptomatically, and supportive measures instituted as required. Due to extensive drug binding to plasma proteins, hemodialysis is not expected to significantly enhance atorvastatin clearance.
Pregnancy & Lactation
Atorvastatin is contraindicated during pregnancy and breastfeeding. It can cause fetal harm when administered to pregnant women. Women of childbearing potential should use adequate contraception during treatment. It is unknown whether atorvastatin or its metabolites are excreted in human milk; however, because of the potential for serious adverse reactions in nursing infants, women taking atorvastatin should not breastfeed.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture.
Availability
Pharmacies, hospitals
Approval Status
Approved by FDA and DGDA
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Atorvastatin has been extensively studied in numerous large-scale clinical trials, such as the ASCOT-LLA, MIRACL, and TNT trials, demonstrating its efficacy in reducing cardiovascular events and mortality in various patient populations.
Lab Monitoring
- Liver function tests (ALT/AST) before initiation and as clinically indicated.
- Lipid panel (total cholesterol, LDL-C, HDL-C, triglycerides) before and during treatment.
- Creatine Kinase (CK) levels if muscle pain, tenderness, or weakness occurs.
Doctor Notes
- Counsel patients on lifestyle modifications (diet, exercise, smoking cessation) as primary therapy.
- Monitor liver function tests periodically, especially if symptoms of liver injury develop.
- Educate patients about muscle pain symptoms and when to report them.
Patient Guidelines
- Take this medicine exactly as prescribed by your doctor, usually once a day.
- Do not stop taking this medicine without consulting your doctor, even if you feel well.
- Maintain a low-fat, low-cholesterol diet and engage in regular exercise as advised by your doctor.
- Report any unexplained muscle pain, tenderness, or weakness, especially if accompanied by fever or malaise, to your doctor immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose (within 12 hours), skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Atorvastatin generally does not impair the ability to drive or operate machinery. However, if you experience dizziness or blurred vision, you should avoid driving or operating heavy machinery until these symptoms resolve.
Lifestyle Advice
- Adopt a healthy diet low in saturated and trans fats.
- Increase physical activity and maintain a healthy weight.
- Quit smoking and limit alcohol consumption.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in Av Brand
Other medicines available under the same brand name
