AV
Generic Name
Amlodipine
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| av 5 mg tablet | ৳ 7.00 | ৳ 98.00 |
Description
Overview of the medicine
AV 5 mg Tablet contains Amlodipine, a calcium channel blocker, used to treat high blood pressure (hypertension) and chest pain (angina). It works by relaxing blood vessels, making it easier for the heart to pump blood.
Uses & Indications
Dosage
Adults
Initial dose 5 mg once daily, maximum 10 mg once daily. Dosage should be adjusted according to patient response.
Elderly
Initial dose 2.5 mg once daily, gradually increase if needed, monitor carefully.
Renal_impairment
No dosage adjustment required.
How to Take
Oral administration. Can be taken with or without food.
Mechanism of Action
Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow channel blocker) that inhibits the transmembrane influx of calcium ions into cardiac and vascular smooth muscle. This leads to vasodilation and reduction in peripheral vascular resistance, lowering blood pressure. In angina, it increases myocardial oxygen delivery.
Pharmacokinetics
Onset
Blood pressure lowering effect starts gradually, within 6-12 hours.
Excretion
Excreted predominantly by the kidneys (approx. 60% as inactive metabolites, 10% as unchanged drug).
Half life
30-50 hours.
Absorption
Well absorbed orally, peak plasma concentrations in 6-12 hours. Bioavailability 64-90%.
Metabolism
Extensively metabolized in the liver to inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to amlodipine or other dihydropyridines
- Severe hypotension
- Cardiogenic shock
- Unstable angina (unless treated with beta-blockers)
Drug Interactions
Sildenafil
Increased risk of hypotension, use with caution.
Simvastatin
Increased risk of myopathy/rhabdomyolysis; limit simvastatin dose to 20 mg/day.
CYP3A4 Inducers (e.g., Rifampicin, Carbamazepine)
May decrease amlodipine exposure, monitor for reduced efficacy.
CYP3A4 Inhibitors (e.g., Ketoconazole, Erythromycin)
May increase amlodipine exposure, monitor for hypotension.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include excessive peripheral vasodilation with marked hypotension and reflex tachycardia. Management involves symptomatic and supportive measures, including monitoring cardiac and respiratory function, elevation of extremities, and intravenous fluids. Vasopressors may be needed. Calcium gluconate may be beneficial.
Pregnancy & Lactation
Use only if the potential benefit justifies the potential risk to the fetus. Excreted in breast milk, use with caution in nursing mothers.
Side Effects
Contraindications
- Hypersensitivity to amlodipine or other dihydropyridines
- Severe hypotension
- Cardiogenic shock
- Unstable angina (unless treated with beta-blockers)
Drug Interactions
Sildenafil
Increased risk of hypotension, use with caution.
Simvastatin
Increased risk of myopathy/rhabdomyolysis; limit simvastatin dose to 20 mg/day.
CYP3A4 Inducers (e.g., Rifampicin, Carbamazepine)
May decrease amlodipine exposure, monitor for reduced efficacy.
CYP3A4 Inhibitors (e.g., Ketoconazole, Erythromycin)
May increase amlodipine exposure, monitor for hypotension.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include excessive peripheral vasodilation with marked hypotension and reflex tachycardia. Management involves symptomatic and supportive measures, including monitoring cardiac and respiratory function, elevation of extremities, and intravenous fluids. Vasopressors may be needed. Calcium gluconate may be beneficial.
Pregnancy & Lactation
Use only if the potential benefit justifies the potential risk to the fetus. Excreted in breast milk, use with caution in nursing mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Pharmacies, hospitals
Approval Status
Approved by major regulatory bodies (e.g., FDA, DGDA)
Patent Status
Off-patent, generic versions available
WHO Essential Medicine
YesClinical Trials
Numerous clinical trials have established the efficacy and safety of amlodipine in hypertension and angina.
Lab Monitoring
- Routine blood pressure monitoring
- Renal function tests (for baseline and as clinically indicated)
- Liver function tests (if hepatic impairment suspected)
Doctor Notes
- Monitor blood pressure regularly.
- Assess for peripheral edema during follow-up.
- Caution in patients with severe hepatic impairment.
Patient Guidelines
- Take medicine as prescribed by your doctor.
- Do not stop taking the medicine suddenly without consulting your doctor.
- Report any unusual side effects immediately.
Missed Dose Advice
If a dose is missed, take it as soon as you remember, unless it is almost time for your next dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness or fatigue, especially at the start of treatment. Exercise caution when driving or operating machinery.
Lifestyle Advice
- Maintain a healthy diet low in sodium and saturated fats.
- Engage in regular physical activity.
- Avoid smoking and excessive alcohol consumption.
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Global Brand Names
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