Avidro
Generic Name
Avidralactone
Manufacturer
Medix Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| avidro 05 mg tablet | ৳ 3.00 | ৳ 30.00 |
Description
Overview of the medicine
Avidro 05 mg Tablet contains Avidralactone, an angiotensin II receptor blocker (ARB) used to treat high blood pressure (hypertension) and heart failure. It helps to relax blood vessels, allowing blood to flow more easily and thereby lowering blood pressure.
Uses & Indications
Dosage
Adults
Initial dose is usually 5 mg once daily. May be increased up to 40 mg daily depending on blood pressure response and tolerability. Maximum dose 80 mg daily.
Elderly
No specific dose adjustment is usually required, but caution is advised in very elderly patients due to potential increased sensitivity.
Renal_impairment
No initial dose adjustment is needed for mild to moderate renal impairment. For severe renal impairment, consider a lower starting dose (e.g., 2.5 mg) and careful monitoring.
How to Take
Administer orally, once daily, with or without food. Swallow the tablet whole with water.
Mechanism of Action
Avidralactone selectively blocks the binding of angiotensin II to the AT1 receptor, which is found in many tissues, including vascular smooth muscle and the adrenal gland. This inhibition prevents the vasoconstrictive and aldosterone-secreting effects of angiotensin II, leading to vasodilation and reduced blood pressure.
Pharmacokinetics
Onset
Antihypertensive effect usually starts within 1-2 hours, with full effect seen within 2-4 weeks of continuous therapy.
Excretion
Mainly excreted unchanged in urine and feces.
Half life
Approximately 6-9 hours.
Absorption
Rapidly absorbed after oral administration, with peak plasma concentrations reached within 1-2 hours. Bioavailability is approximately 30-40%.
Metabolism
Minimally metabolized by the liver, primarily via glucuronidation.
Side Effects
Contraindications
- Hypersensitivity to Avidralactone or any component of the formulation
- Pregnancy (especially second and third trimesters)
- Concomitant use with aliskiren in patients with diabetes or renal impairment (GFR < 60 mL/min/1.73 m²)
Drug Interactions
Lithium
May increase serum lithium concentrations and lead to lithium toxicity.
NSAIDs (e.g., ibuprofen, naproxen)
May reduce the antihypertensive effect and worsen renal function in dehydrated or elderly patients.
Potassium-sparing diuretics or potassium supplements
May lead to increased serum potassium levels (hyperkalemia).
Storage
Store in a cool, dry place below 30°C, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include profound hypotension (low blood pressure) and tachycardia; bradycardia could occur from parasympathetic stimulation. Treatment is symptomatic and supportive. Administer activated charcoal shortly after ingestion. Intravenous normal saline infusion may be required to support blood pressure.
Pregnancy & Lactation
Category D in pregnancy (second and third trimesters) due to fetal toxicity. Not recommended during breastfeeding as it is unknown if Avidralactone is excreted in human milk. Consult a doctor immediately if you are pregnant or planning to breastfeed.
Side Effects
Contraindications
- Hypersensitivity to Avidralactone or any component of the formulation
- Pregnancy (especially second and third trimesters)
- Concomitant use with aliskiren in patients with diabetes or renal impairment (GFR < 60 mL/min/1.73 m²)
Drug Interactions
Lithium
May increase serum lithium concentrations and lead to lithium toxicity.
NSAIDs (e.g., ibuprofen, naproxen)
May reduce the antihypertensive effect and worsen renal function in dehydrated or elderly patients.
Potassium-sparing diuretics or potassium supplements
May lead to increased serum potassium levels (hyperkalemia).
Storage
Store in a cool, dry place below 30°C, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include profound hypotension (low blood pressure) and tachycardia; bradycardia could occur from parasympathetic stimulation. Treatment is symptomatic and supportive. Administer activated charcoal shortly after ingestion. Intravenous normal saline infusion may be required to support blood pressure.
Pregnancy & Lactation
Category D in pregnancy (second and third trimesters) due to fetal toxicity. Not recommended during breastfeeding as it is unknown if Avidralactone is excreted in human milk. Consult a doctor immediately if you are pregnant or planning to breastfeed.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture.
Availability
Available at all licensed pharmacies and hospitals
Approval Status
Approved by regulatory authorities (e.g., DGDA)
Patent Status
Patent expired/Generic available
Clinical Trials
Clinical trials demonstrated significant blood pressure reduction and favorable safety profile compared to placebo. Long-term studies confirmed cardiovascular benefits in high-risk patients.
Lab Monitoring
- Serum creatinine and potassium levels (especially at initiation and dose escalation)
- Blood pressure monitoring
Doctor Notes
- Regular monitoring of blood pressure, renal function, and serum electrolytes is advised, particularly during initiation and dose adjustments.
- Educate patients on symptoms of angioedema and hyperkalemia.
- Avoid concomitant use with ACE inhibitors or aliskiren due to increased risk of adverse events.
Patient Guidelines
- Take the medicine at the same time each day.
- Do not stop taking the medicine without consulting your doctor.
- Monitor your blood pressure regularly as advised by your doctor.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to make up for a missed one.
Driving Precautions
May cause dizziness or fatigue. If affected, avoid driving or operating heavy machinery until you know how Avidro affects you.
Lifestyle Advice
- Adopt a healthy diet low in sodium and saturated fats.
- Engage in regular physical activity.
- Avoid smoking and limit alcohol intake.
- Maintain a healthy weight.
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Global Brand Names
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