Avidro
Generic Name
Avanafil
Manufacturer
Acme Pharmaceuticals (Hypothetical)
Country
USA (Hypothetical)
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| avidro 15 mg tablet | ৳ 7.00 | ৳ 70.00 |
Description
Overview of the medicine
Avanafil is a phosphodiesterase-5 (PDE5) inhibitor used to treat erectile dysfunction (ED). It helps men achieve and maintain an erection by increasing blood flow to the penis when sexually stimulated.
Uses & Indications
Dosage
Adults
The recommended starting dose of Avidro is 15 mg, taken orally as needed, approximately 15 to 30 minutes before sexual activity. The dose may be increased or decreased based on efficacy and tolerability, but 15 mg is the prescribed strength here. Do not exceed one dose per day.
Elderly
No specific dosage adjustment is required for elderly patients based on age alone, but caution is advised, and lower starting doses may be considered if co-morbidities or concomitant medications warrant.
Renal_impairment
No dose adjustment is required for patients with mild to moderate renal impairment. Use with caution in severe renal impairment, and specific dosage recommendations might vary.
How to Take
Oral, with or without food, approximately 15-30 minutes before sexual activity.
Mechanism of Action
Avanafil selectively inhibits cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5) in the corpus cavernosum of the penis. When sexual stimulation causes local release of nitric oxide, PDE5 inhibition by avanafil increases cGMP levels, leading to smooth muscle relaxation and inflow of blood into the penis, resulting in an erection.
Pharmacokinetics
Onset
~15-30 minutes.
Excretion
Excreted predominantly via feces (62%) and to a lesser extent via urine (36%) as metabolites.
Half life
~6-17 hours (terminal half-life).
Absorption
Rapidly absorbed, Cmax reached in 30-45 minutes. Bioavailability ~20-40%.
Metabolism
Primarily hepatic, mainly by CYP3A4 and to a lesser extent by CYP2C9.
Side Effects
Contraindications
- Concomitant use with nitrates (e.g., nitroglycerin)
- Hypersensitivity to avanafil or any component
- Severe cardiovascular disease (e.g., recent MI or stroke, unstable angina)
- Severe hepatic impairment
- End-stage renal disease requiring dialysis
- Concomitant use with alpha-blockers in patients with uncontrolled hypertension
- Concomitant use with strong CYP3A4 inhibitors (e.g., ketoconazole, ritonavir)
Drug Interactions
Nitrates
Potentiation of hypotensive effects, potentially life-threatening. Absolutely contraindicated.
Alpha-blockers
Increased risk of symptomatic hypotension. Use with caution, initiate at lowest dose.
Strong CYP3A4 Inhibitors (e.g., Ketoconazole, Ritonavir)
Significantly increases avanafil exposure. Concomitant use is contraindicated.
Moderate CYP3A4 Inhibitors (e.g., Erythromycin, Diltiazem)
Increased avanafil exposure, dosage adjustment may be needed.
Storage
Store below 30°C in a dry place, away from light. Keep out of reach of children.
Overdose
In cases of overdose, standard supportive measures should be adopted as required. Renal dialysis is not expected to accelerate clearance as avanafil is highly bound to plasma proteins and not significantly renally eliminated.
Pregnancy & Lactation
Not indicated for use in women.
Side Effects
Contraindications
- Concomitant use with nitrates (e.g., nitroglycerin)
- Hypersensitivity to avanafil or any component
- Severe cardiovascular disease (e.g., recent MI or stroke, unstable angina)
- Severe hepatic impairment
- End-stage renal disease requiring dialysis
- Concomitant use with alpha-blockers in patients with uncontrolled hypertension
- Concomitant use with strong CYP3A4 inhibitors (e.g., ketoconazole, ritonavir)
Drug Interactions
Nitrates
Potentiation of hypotensive effects, potentially life-threatening. Absolutely contraindicated.
Alpha-blockers
Increased risk of symptomatic hypotension. Use with caution, initiate at lowest dose.
Strong CYP3A4 Inhibitors (e.g., Ketoconazole, Ritonavir)
Significantly increases avanafil exposure. Concomitant use is contraindicated.
Moderate CYP3A4 Inhibitors (e.g., Erythromycin, Diltiazem)
Increased avanafil exposure, dosage adjustment may be needed.
Storage
Store below 30°C in a dry place, away from light. Keep out of reach of children.
Overdose
In cases of overdose, standard supportive measures should be adopted as required. Renal dialysis is not expected to accelerate clearance as avanafil is highly bound to plasma proteins and not significantly renally eliminated.
Pregnancy & Lactation
Not indicated for use in women.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months
Availability
Pharmacies, Hospitals
Approval Status
Approved (e.g., FDA, DGDA)
Patent Status
Generic available
Clinical Trials
Extensive clinical trials demonstrated efficacy and safety in men with ED across various etiologies.
Lab Monitoring
- Generally, no specific routine lab monitoring is required.
Doctor Notes
- Emphasize thorough cardiovascular assessment before prescribing.
- Counsel patients on potential interactions, especially with nitrates.
- Reinforce 'as-needed' dosing and not to exceed daily limit.
Patient Guidelines
- Take 15-30 minutes before sexual activity.
- Do not take more than once daily.
- Avoid alcohol consumption with this medicine.
- Seek immediate medical attention for an erection lasting longer than 4 hours (priapism).
- Inform your doctor about all other medications you are taking, especially nitrates and alpha-blockers.
Missed Dose Advice
Since Avidro is taken on an as-needed basis, a missed dose is not applicable. Take it when needed, before sexual activity. Do not take more than once a day.
Driving Precautions
May cause dizziness or visual disturbances. Patients should be aware of how they react to Avidro before driving or operating machinery.
Lifestyle Advice
- Maintain a healthy lifestyle, including regular exercise and a balanced diet, to support overall cardiovascular health.
- Reduce stress levels.
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