Azilpres
Generic Name
Azilsartan Medoxomil
Manufacturer
ACI Limited
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| azilpres 40 mg tablet | ৳ 12.00 | ৳ 120.00 |
Description
Overview of the medicine
Azilpres 40 mg Tablet contains Azilsartan Medoxomil, an angiotensin II receptor blocker (ARB) used for the treatment of essential hypertension (high blood pressure) in adults. It helps to relax blood vessels, allowing blood to flow more easily.
Uses & Indications
Dosage
Adults
The recommended initial dose is 40 mg orally once daily. The dose may be increased to a maximum of 80 mg once daily if necessary.
Elderly
No initial dose adjustment is generally required for elderly patients (≥65 years), but careful monitoring is advised.
Renal_impairment
No initial dose adjustment is necessary for patients with mild to moderate renal impairment. For patients with severe renal impairment (creatinine clearance <30 mL/min), use with caution and monitor closely.
How to Take
Take Azilpres 40 mg Tablet orally once daily, with or without food. Swallow the tablet whole with water. Do not crush or chew.
Mechanism of Action
Azilsartan Medoxomil is a prodrug that is rapidly converted to azilsartan, the active moiety. Azilsartan selectively blocks the binding of angiotensin II to the AT1 receptor in various tissues, including vascular smooth muscle and the adrenal gland. This inhibition prevents the vasoconstrictor and aldosterone-secreting effects of angiotensin II, leading to vasodilation and a reduction in blood pressure.
Pharmacokinetics
Onset
Blood pressure reduction within 1-2 hours; maximal effect within 2 weeks.
Excretion
Primarily excreted in feces (approximately 55%) and urine (approximately 42%).
Half life
Approximately 11 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract after oral administration. Peak plasma concentrations are reached within 1-3 hours. Absolute bioavailability is approximately 60%.
Metabolism
Metabolized by O-dealkylation, primarily by CYP2C9 enzyme, and further by carboxylation. Not extensively metabolized by cytochrome P450 enzymes.
Side Effects
Contraindications
- •Hypersensitivity to azilsartan or any component of the formulation.
- •Pregnancy (second and third trimesters) due to fetal toxicity.
- •Concomitant use with aliskiren in patients with diabetes mellitus or renal impairment (GFR <60 mL/min/1.73 m²).
Drug Interactions
Lithium
Increased serum lithium concentrations and toxicity. Monitor serum lithium levels.
Aliskiren
Contraindicated in patients with diabetes or renal impairment (e.g., Azilpres 40 mg Tablet).
NSAIDs (Non-Steroidal Anti-Inflammatory Drugs)
May reduce the antihypertensive effect and increase the risk of renal impairment, especially in elderly, dehydrated patients.
Potassium-sparing diuretics/Potassium supplements
May lead to increased serum potassium levels (hyperkalemia).
Storage
Store below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include hypotension (low blood pressure), dizziness, and possibly tachycardia or bradycardia. Treatment is symptomatic and supportive. If ingestion is recent, gastric lavage or activated charcoal may be considered. Intravenous fluids may be administered for hypotension. Hemodialysis is unlikely to remove azilsartan effectively.
Pregnancy & Lactation
Pregnancy Category D (2nd and 3rd trimesters). Can cause fetal harm or death. Discontinue if pregnancy is detected. It is unknown if azilsartan is excreted in human milk; caution should be exercised when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months from manufacturing date.
Availability
Available in pharmacies nationwide
Approval Status
Approved by regulatory bodies (e.g., FDA, DGDA)
Patent Status
Varies by region, some patents may have expired allowing generics
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Global Brand Names
International brand names for this medicine
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