Azilpres
Generic Name
Azilsartan Medoxomil
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| azilpres 80 mg tablet | ৳ 22.00 | ৳ 220.00 |
Description
Overview of the medicine
Azilpres 80 mg Tablet contains Azilsartan Medoxomil, an angiotensin II receptor blocker (ARB), used to treat high blood pressure (hypertension). It helps to relax blood vessels, allowing blood to flow more easily.
Uses & Indications
Dosage
Adults
The recommended starting dose is 40 mg once daily. The dose may be increased to 80 mg once daily if necessary. Take with or without food.
Elderly
No initial dose adjustment is generally required for elderly patients.
Renal_impairment
No initial dose adjustment is required for patients with mild to moderate renal impairment. For severe impairment, caution is advised, and lower doses may be considered.
How to Take
Take orally once daily, with or without food. Swallow the tablet whole with water. Do not crush or chew.
Mechanism of Action
Azilsartan Medoxomil is a prodrug that is hydrolyzed to azilsartan, the active moiety. Azilsartan selectively blocks the binding of angiotensin II to the AT1 receptor, which is found in many tissues (e.g., vascular smooth muscle, adrenal gland). This blockade inhibits the vasoconstrictive and aldosterone-secreting effects of angiotensin II, leading to vasodilation and reduction in blood pressure.
Pharmacokinetics
Onset
Within 1-2 hours for blood pressure reduction, full effect within 2-4 weeks.
Excretion
Primarily excreted in feces (55%) and urine (42%).
Half life
Approximately 11 hours.
Absorption
Rapidly absorbed after oral administration. Peak plasma concentrations of azilsartan are achieved within 1-3 hours. Bioavailability is approximately 60%.
Metabolism
Metabolized by O-demethylation (CYP2C9, CYP2B6) to inactive metabolites.
Side Effects
Contraindications
- •Hypersensitivity to azilsartan medoxomil or any component of the formulation.
- •Concomitant use with aliskiren in patients with diabetes or renal impairment.
- •Pregnancy (second and third trimesters).
Drug Interactions
Lithium
Increased serum lithium concentrations and toxicity have been reported with concomitant use of ARBs. Monitor lithium levels.
Diuretics
Increased risk of hypotension, especially with initial dosing.
NSAIDs (Nonsteroidal Anti-inflammatory Drugs)
May reduce the antihypertensive effect of Azilsartan and increase the risk of renal impairment, especially in elderly or volume-depleted patients.
Potassium-sparing diuretics, potassium supplements, or other agents that may increase potassium levels
May lead to hyperkalemia. Monitor serum potassium.
Storage
Store at room temperature (below 30°C). Protect from moisture and light. Keep out of reach of children.
Overdose
Limited data on overdose. Symptoms may include hypotension and tachycardia; bradycardia could occur from parasympathetic stimulation. Treatment is symptomatic and supportive. If ingestion is recent, gastric lavage may be considered. Administer activated charcoal. Closely monitor vital signs and manage fluid and electrolyte balance.
Pregnancy & Lactation
Not recommended during pregnancy, especially in the second and third trimesters, due to risk of fetal harm. Discontinue if pregnancy is detected. It is not known whether azilsartan is excreted in human milk, so caution should be exercised if used during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from the date of manufacture.
Availability
Pharmacies, hospitals, clinics
Approval Status
Approved by regulatory authorities
Patent Status
Patent expired for generic, brand may have local patent
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