Medicine Information

Azilpres

Name: Azilpres
Brand: Azilpres
Rating: 4.5 (117 reviews)

Tablet80 mgAntihypertensiveATC: C09CA09

Generic Name

Azilsartan Medoxomil

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
azilpres 80 mg tablet	৳ 22.00	৳ 220.00

Description

Overview of the medicine

Azilpres 80 mg Tablet contains Azilsartan Medoxomil, an angiotensin II receptor blocker (ARB), used to treat high blood pressure (hypertension). It helps to relax blood vessels, allowing blood to flow more easily.

Uses & Indications

Treatment of essential hypertension (high blood pressure) in adults.

Dosage

Adults

The recommended starting dose is 40 mg once daily. The dose may be increased to 80 mg once daily if necessary. Take with or without food.

Elderly

No initial dose adjustment is generally required for elderly patients.

Renal_impairment

No initial dose adjustment is required for patients with mild to moderate renal impairment. For severe impairment, caution is advised, and lower doses may be considered.

How to Take

Take orally once daily, with or without food. Swallow the tablet whole with water. Do not crush or chew.

Mechanism of Action

Azilsartan Medoxomil is a prodrug that is hydrolyzed to azilsartan, the active moiety. Azilsartan selectively blocks the binding of angiotensin II to the AT1 receptor, which is found in many tissues (e.g., vascular smooth muscle, adrenal gland). This blockade inhibits the vasoconstrictive and aldosterone-secreting effects of angiotensin II, leading to vasodilation and reduction in blood pressure.

Pharmacokinetics

Onset

Within 1-2 hours for blood pressure reduction, full effect within 2-4 weeks.

Excretion

Primarily excreted in feces (55%) and urine (42%).

Half life

Approximately 11 hours.

Absorption

Rapidly absorbed after oral administration. Peak plasma concentrations of azilsartan are achieved within 1-3 hours. Bioavailability is approximately 60%.

Metabolism

Metabolized by O-demethylation (CYP2C9, CYP2B6) to inactive metabolites.

Side Effects

Contraindications

Hypersensitivity to azilsartan medoxomil or any component of the formulation.
Concomitant use with aliskiren in patients with diabetes or renal impairment.
Pregnancy (second and third trimesters).

Drug Interactions

Lithium

Increased serum lithium concentrations and toxicity have been reported with concomitant use of ARBs. Monitor lithium levels.

Diuretics

Increased risk of hypotension, especially with initial dosing.

NSAIDs (Nonsteroidal Anti-inflammatory Drugs)

May reduce the antihypertensive effect of Azilsartan and increase the risk of renal impairment, especially in elderly or volume-depleted patients.

Potassium-sparing diuretics, potassium supplements, or other agents that may increase potassium levels

May lead to hyperkalemia. Monitor serum potassium.

Storage

Store at room temperature (below 30°C). Protect from moisture and light. Keep out of reach of children.

Overdose

Limited data on overdose. Symptoms may include hypotension and tachycardia; bradycardia could occur from parasympathetic stimulation. Treatment is symptomatic and supportive. If ingestion is recent, gastric lavage may be considered. Administer activated charcoal. Closely monitor vital signs and manage fluid and electrolyte balance.

Pregnancy & Lactation

Not recommended during pregnancy, especially in the second and third trimesters, due to risk of fetal harm. Discontinue if pregnancy is detected. It is not known whether azilsartan is excreted in human milk, so caution should be exercised if used during lactation.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 tablets per box30 tablets per box

Shelf Life

Typically 2-3 years from the date of manufacture.

Availability

Pharmacies, hospitals, clinics

Approval Status

Approved by regulatory authorities

Patent Status

Patent expired for generic, brand may have local patent

Clinical Trials

Extensive clinical trials (e.g., ALTITUDE, BRIDGE studies) have demonstrated the efficacy and safety of azilsartan medoxomil in reducing blood pressure in patients with hypertension. These trials evaluated its effect as monotherapy and in combination with other antihypertensive agents.

Lab Monitoring

Serum potassium levels (especially in patients with renal impairment or on potassium-sparing diuretics)
Renal function (creatinine, GFR)
Blood pressure monitoring

Doctor Notes

Monitor blood pressure regularly.
Assess renal function and serum potassium before and periodically during treatment.
Educate patients about the risk of fetal toxicity.

Patient Guidelines

Take the tablet at the same time each day.
Do not stop taking the medicine without consulting your doctor, even if you feel well.
Inform your doctor if you become pregnant or plan to become pregnant.
Avoid potassium supplements or salt substitutes containing potassium without consulting your doctor.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your usual dosing schedule. Do not take a double dose to make up for a missed one.

Driving Precautions

May cause dizziness or fatigue, especially at the start of treatment or when the dose is increased. If affected, avoid driving or operating machinery.