Azobrin
Generic Name
Brinzolamide
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| azobrin 1 suspension | ৳ 500.00 | N/A |
Description
Overview of the medicine
Azobrin (Brinzolamide) is a topical carbonic anhydrase inhibitor used to lower elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma.
Uses & Indications
Dosage
Adults
One drop in the affected eye(s) three times daily.
Elderly
No dosage adjustment required for elderly patients.
Renal_impairment
Use with caution in patients with severe renal impairment (creatinine clearance <30 mL/min). Not recommended in end-stage renal disease.
How to Take
For ophthalmic use only. Shake well before use. Apply one drop into the conjunctival sac of the affected eye(s). Avoid touching the dropper tip to the eye or any other surface.
Mechanism of Action
Brinzolamide inhibits carbonic anhydrase in the ciliary body of the eye. This inhibition reduces the formation of bicarbonate ions, which in turn reduces sodium and fluid transport, thereby decreasing aqueous humor secretion and lowering intraocular pressure.
Pharmacokinetics
Onset
Onset of IOP lowering effect is typically within 2 hours.
Excretion
Excreted predominantly by the kidneys, primarily as unchanged drug and its metabolite.
Half life
The apparent half-life in red blood cells is approximately 111 days.
Absorption
After ocular administration, brinzolamide is absorbed into the systemic circulation. It binds extensively to carbonic anhydrase in red blood cells.
Metabolism
Metabolized primarily to N-desethylbrinzolamide, which also binds to carbonic anhydrase.
Side Effects
Contraindications
- Hypersensitivity to the active substance or to any of the excipients
- Hypersensitivity to sulfonamides
- Severe renal impairment (creatinine clearance <30 mL/min)
- Hyperchloraemic acidosis
Drug Interactions
High-dose Salicylates
Caution advised due to potential for acid-base disturbances.
Oral Carbonic Anhydrase Inhibitors
Increased risk of systemic side effects when used concurrently.
Storage
Store at controlled room temperature (15-30°C). Protect from light. Do not freeze. Keep out of reach of children.
Overdose
Topical overdose is unlikely to cause systemic toxicity due to limited systemic absorption. In case of accidental oral ingestion, symptoms similar to systemic carbonic anhydrase inhibitors (e.g., electrolyte imbalance, acidosis, CNS depression) might occur. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is not known whether brinzolamide is excreted in human milk; caution should be exercised when administered to a nursing woman.
Side Effects
Contraindications
- Hypersensitivity to the active substance or to any of the excipients
- Hypersensitivity to sulfonamides
- Severe renal impairment (creatinine clearance <30 mL/min)
- Hyperchloraemic acidosis
Drug Interactions
High-dose Salicylates
Caution advised due to potential for acid-base disturbances.
Oral Carbonic Anhydrase Inhibitors
Increased risk of systemic side effects when used concurrently.
Storage
Store at controlled room temperature (15-30°C). Protect from light. Do not freeze. Keep out of reach of children.
Overdose
Topical overdose is unlikely to cause systemic toxicity due to limited systemic absorption. In case of accidental oral ingestion, symptoms similar to systemic carbonic anhydrase inhibitors (e.g., electrolyte imbalance, acidosis, CNS depression) might occur. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is not known whether brinzolamide is excreted in human milk; caution should be exercised when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months for unopened bottle. Discard 4 weeks after opening.
Availability
Available in pharmacies and hospitals
Approval Status
Approved
Patent Status
Off-patent
Clinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of brinzolamide in reducing intraocular pressure in patients with glaucoma or ocular hypertension. Key studies include comparisons with other carbonic anhydrase inhibitors and beta-blockers.
Lab Monitoring
- Routine laboratory monitoring is generally not required for topical brinzolamide. However, in patients with severe renal impairment or those concomitantly receiving oral carbonic anhydrase inhibitors, monitoring of serum electrolytes (especially bicarbonate) is advised.
Doctor Notes
- Emphasize proper administration technique to patients to minimize contamination and maximize efficacy.
- Be mindful of potential systemic absorption and associated side effects, especially in susceptible patient populations.
- Advise patients on the importance of adherence for sustained IOP control.
Patient Guidelines
- Remove contact lenses before application and wait at least 15 minutes before reinserting.
- Do not allow the dropper tip to touch the eye or surrounding areas to avoid contamination.
- Shake the bottle well before each use.
- If using other ophthalmic medications, wait at least 5 minutes between applications.
Missed Dose Advice
If a dose is missed, apply it as soon as possible. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Azobrin may cause transient blurred vision and dizziness immediately after administration. Patients should be advised not to drive or operate machinery until their vision clears.
Lifestyle Advice
- Regular follow-up appointments with your ophthalmologist are crucial to monitor IOP and overall eye health.
- Adhere strictly to the prescribed dosage and administration schedule to achieve optimal therapeutic effect.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in Azobrin Brand
Other medicines available under the same brand name
