Baclon
Generic Name
Baclofen
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| baclon 10 mg tablet | ৳ 11.00 | ৳ 110.00 |
Description
Overview of the medicine
Baclofen is a centrally acting skeletal muscle relaxant used to treat spasticity resulting from multiple sclerosis, spinal cord injuries, and other spinal cord diseases.
Uses & Indications
Dosage
Adults
Initial dose: 5 mg three times daily. May be increased by 5 mg every 3 days to a maximum of 80 mg/day (20 mg four times daily).
Elderly
Start with lower doses and titrate slowly due to increased sensitivity and potential for adverse effects.
Renal_impairment
Dose should be reduced in patients with renal impairment, with careful monitoring.
How to Take
Administer orally, preferably with food or milk to minimize gastric irritation.
Mechanism of Action
Baclofen acts as a GABA-B receptor agonist, leading to hyperpolarization of neurons and a reduction in excitatory neurotransmitter release, thereby decreasing muscle spasticity.
Pharmacokinetics
Onset
Onset of action is usually within 1-2 hours.
Excretion
Approximately 70-80% excreted unchanged in urine, with some biliary excretion.
Half life
Plasma half-life is 3-4 hours.
Absorption
Rapidly and extensively absorbed from the gastrointestinal tract.
Metabolism
Minimally metabolized in the liver (approximately 15% of the dose).
Side Effects
Contraindications
- •Hypersensitivity to Baclofen or any component of the formulation
Drug Interactions
Tricyclic Antidepressants (TCAs)
May potentiate muscle relaxant effects and cause pronounced hypotonia.
CNS Depressants (e.g., alcohol, opioids, benzodiazepines)
Increased CNS depression, drowsiness, and respiratory depression.
Storage
Store at controlled room temperature (20-25°C), away from moisture and direct light. Keep out of reach of children.
Overdose
Symptoms include drowsiness, coma, respiratory depression, seizures, and hypothermia. Management involves supportive care, gastric lavage if recent ingestion, and respiratory support as needed.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. Excreted in breast milk; use with caution in breastfeeding mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2 to 3 years from manufacturing date.
Availability
Available in pharmacies worldwide
Approval Status
Approved by major regulatory bodies globally
Patent Status
Off-patent (Generic available)
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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