Medicine Information

Baclon

Name: Baclon
Brand: Baclon
Rating: 4.5 (117 reviews)

Tablet5 mgSkeletal Muscle RelaxantATC: M03BX01

Generic Name

Baclofen

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
baclon 5 mg tablet	৳ 5.50	৳ 55.00

Description

Overview of the medicine

Baclofen 5 mg Tablet is a muscle relaxant used to treat muscle spasms, stiffness, and pain caused by certain conditions like multiple sclerosis, spinal cord injury, or other neurological disorders. It works by calming overactive nerves in the brain and spinal cord that control muscle movement.

Uses & Indications

Treatment of spasticity resulting from multiple sclerosis

Treatment of spasticity resulting from spinal cord lesions and other neurological conditions (e.g., cerebral palsy)

Adjunctive treatment in trigeminal neuralgia

Dosage

Adults

Initial dose is 5 mg three times daily (TID) for 3 days. Dosage may be increased by 5 mg TID increments every 3 days until optimal response is achieved. Maximum recommended daily dose is 80 mg (e.g., 20 mg four times daily).

Elderly

Start with a low dose (e.g., 5 mg once or twice daily) and increase gradually to minimize adverse effects, as elderly patients may be more sensitive to the effects.

Renal_impairment

Lower doses are required in patients with renal impairment. Dosage should be reduced significantly, and caution is advised. Consult a doctor for specific dosing.

How to Take

Take Baclon 5 mg Tablet orally, usually with food or milk to reduce gastrointestinal upset. Swallow the tablet whole with water. Do not crush, chew, or break it.

Mechanism of Action

Baclofen is a gamma-aminobutyric acid (GABA) derivative that acts as a GABA-B receptor agonist. It inhibits both mono- and polysynaptic reflexes at the spinal level, leading to reduced spasticity by hyperpolarizing afferent terminals and inhibiting the release of excitatory neurotransmitters.

Pharmacokinetics

Onset

Onset of action is usually within 0.5 to 1 hour.

Excretion

Primarily excreted unchanged by the kidneys (70-80% within 72 hours). A small amount is excreted in feces.

Half life

Plasma elimination half-life is approximately 2.5 to 4 hours.

Absorption

Rapid and extensive absorption from the gastrointestinal tract. Peak plasma concentrations are achieved within 2-3 hours.

Metabolism

Minimal hepatic metabolism; about 15% is metabolized by deamination.

Side Effects

Contraindications

Hypersensitivity to Baclofen or any component of the formulation.
Acute peptic ulcer.

Drug Interactions

Antihypertensives

May cause an additive hypotensive effect, leading to lower blood pressure.

Levodopa/Carbidopa

Possible increased risk of confusion, hallucinations, and agitation.

Tricyclic Antidepressants (TCAs)

May potentiate the effects of Baclofen, leading to increased muscle hypotonia.

Monoamine Oxidase Inhibitors (MAOIs)

Potential for increased CNS depression and hypotensive effects. Use with caution.

CNS Depressants (e.g., alcohol, opioids, benzodiazepines)

Increased central nervous system depression, including drowsiness and respiratory depression.

Storage

Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.

Overdose

Symptoms of overdose include drowsiness, dizziness, nausea, vomiting, muscle weakness, hypothermia, respiratory depression, seizures, and coma. Treatment is primarily supportive, including gastric lavage or induced emesis if recent ingestion, and respiratory support. There is no specific antidote.

Pregnancy & Lactation

Baclofen should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is excreted in breast milk in small amounts; therefore, caution should be exercised when administered to a nursing woman. Consult your doctor.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

30 tablets (3 x 10's in blister)

Shelf Life

Typically 2-3 years from the date of manufacture.

Availability

Available in pharmacies nationwide

Approval Status

Approved by DGDA

Patent Status

Off-patent

WHO Essential Medicine

Yes

Clinical Trials

Baclofen has undergone extensive clinical trials demonstrating its efficacy and safety in managing spasticity from various neurological disorders. Further research continues for its potential use in other conditions.

Lab Monitoring

Periodic assessment of renal function is recommended, especially in patients with impaired kidney function.
Liver function tests may be monitored if long-term therapy is anticipated.

Doctor Notes

Counsel patients on the importance of gradual tapering to prevent severe withdrawal symptoms.
Monitor for CNS depression, especially when co-administered with other CNS depressants.
Exercise caution in patients with impaired renal function; dose adjustment is necessary.
Advise against driving or operating machinery until the patient knows their response to the drug.

Patient Guidelines

Do not stop taking Baclon suddenly; gradually reduce the dose as directed by your doctor to avoid withdrawal symptoms.
Avoid alcohol and other CNS depressants while taking this medicine as it can increase drowsiness and dizziness.
Take this medicine with food or milk to lessen stomach upset.
Be cautious when driving or operating machinery until you know how this medicine affects you.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.

Driving Precautions

Baclofen may cause drowsiness, dizziness, and blurred vision. Avoid driving or operating heavy machinery until you know how this medicine affects you and are sure you can perform such activities safely.

Lifestyle Advice

Regular physical therapy and stretching exercises can complement the effects of Baclofen in managing spasticity.
Ensure adequate hydration and a balanced diet.