Becobion
Generic Name
Thiamine Mononitrate (Vitamin B1)
Manufacturer
Roche (Historically), Multiple Manufacturers (Generics)
Country
Multiple (Switzerland for original brand)
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| becobion 100 mg tablet | ৳ 13.00 | ৳ 130.00 |
Description
Overview of the medicine
Becobion 100 mg Tablet is a vitamin B1 (Thiamine) supplement used to treat or prevent thiamine deficiency and associated conditions.
Uses & Indications
Dosage
Adults
Typical dose for deficiency prevention is 5-30 mg daily. For therapeutic treatment of severe deficiency, doses up to 100 mg three times daily may be given.
Elderly
No specific dosage adjustment is generally needed for the elderly; adult doses are usually appropriate.
Renal_impairment
No specific dosage adjustment is generally needed as thiamine is water-soluble and excreted renally. However, extreme impairment might warrant caution.
How to Take
Becobion 100 mg Tablet should be taken orally, with or without food. Follow the dose recommended by your doctor or pharmacist.
Mechanism of Action
Thiamine acts as a coenzyme in various metabolic pathways, particularly in carbohydrate metabolism, facilitating the conversion of carbohydrates into energy. It is crucial for nerve function and muscle contraction.
Pharmacokinetics
Onset
Clinical improvement usually seen within days to weeks depending on the severity of deficiency.
Excretion
Excreted in the urine as metabolites and unchanged thiamine when intake exceeds tissue requirements.
Half life
Approximately 9-18 days in the body (total body stores). Plasma half-life is shorter.
Absorption
Readily absorbed from the gastrointestinal tract, primarily in the duodenum and ileum, through active transport at low concentrations and passive diffusion at higher concentrations.
Metabolism
Metabolized in the liver to thiamine pyrophosphate (TPP), the active form, which is essential for carbohydrate metabolism.
Side Effects
Contraindications
- •Known hypersensitivity to thiamine or any components of the formulation.
Drug Interactions
Fluorouracil
May increase thiamine deficiency by inhibiting its phosphorylation.
Oral contraceptives
May lower thiamine levels.
Diuretics (e.g., Furosemide)
May increase urinary excretion of thiamine.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Thiamine has a very low toxicity, even at high doses. Acute overdose is rare and generally not associated with serious adverse effects. Treatment is usually supportive, if required.
Pregnancy & Lactation
Thiamine is essential during pregnancy and lactation. Recommended daily allowances should be met. Becobion 100 mg Tablet can be used safely under medical supervision if a deficiency is present or for supplementation as advised by a healthcare professional.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2 to 3 years from the date of manufacture.
Availability
Available in pharmacies and drugstores
Approval Status
Approved by relevant drug authorities
Patent Status
Off-patent
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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