Benkinson
Generic Name
Benifloxacin 50 mg Capsule
Manufacturer
MediGen Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| benkinson 50 mg capsule | ৳ 8.00 | ৳ 80.00 |
Description
Overview of the medicine
Benkinson 50 mg Capsule contains Benifloxacin, a broad-spectrum fluoroquinolone antibiotic used to treat various bacterial infections.
Uses & Indications
Dosage
Adults
50 mg once daily for 7-14 days, depending on the infection.
Elderly
No specific dose adjustment required unless renal impairment is present.
Renal_impairment
Dose adjustment required for CrCl < 30 mL/min; typically 25 mg once daily.
How to Take
Take orally with a glass of water, with or without food. Do not chew or crush the capsule.
Mechanism of Action
Benifloxacin inhibits bacterial DNA gyrase and topoisomerase IV, essential enzymes involved in bacterial DNA replication, transcription, repair, and recombination, leading to bacterial cell death.
Pharmacokinetics
Onset
Varies based on infection type, generally within 24-48 hours.
Excretion
Primarily excreted unchanged via the kidneys.
Half life
Approximately 6-8 hours.
Absorption
Rapidly and well absorbed from the gastrointestinal tract. Peak plasma concentrations are achieved within 1-2 hours.
Metabolism
Minimally metabolized in the liver.
Side Effects
Contraindications
- Hypersensitivity to Benifloxacin or other fluoroquinolones
- History of tendon disorders associated with fluoroquinolones
- Children under 18 years
Drug Interactions
Warfarin
May enhance anticoagulant effects, requiring INR monitoring.
Theophylline
May increase theophylline levels and risk of toxicity.
Antacids containing magnesium or aluminum
Can reduce Benifloxacin absorption. Administer at least 2 hours before or 6 hours after antacids.
Storage
Store below 30°C in a dry place, away from direct sunlight. Keep out of reach of children.
Overdose
In case of overdose, symptoms may include nausea, vomiting, dizziness, and confusion. Treatment is symptomatic and supportive, including gastric lavage and activated charcoal if appropriate. Hemodialysis is not effective.
Pregnancy & Lactation
Not recommended during pregnancy due to potential fetal risks. Excreted in breast milk, avoid during lactation or use with caution after consulting a doctor.
Side Effects
Contraindications
- Hypersensitivity to Benifloxacin or other fluoroquinolones
- History of tendon disorders associated with fluoroquinolones
- Children under 18 years
Drug Interactions
Warfarin
May enhance anticoagulant effects, requiring INR monitoring.
Theophylline
May increase theophylline levels and risk of toxicity.
Antacids containing magnesium or aluminum
Can reduce Benifloxacin absorption. Administer at least 2 hours before or 6 hours after antacids.
Storage
Store below 30°C in a dry place, away from direct sunlight. Keep out of reach of children.
Overdose
In case of overdose, symptoms may include nausea, vomiting, dizziness, and confusion. Treatment is symptomatic and supportive, including gastric lavage and activated charcoal if appropriate. Hemodialysis is not effective.
Pregnancy & Lactation
Not recommended during pregnancy due to potential fetal risks. Excreted in breast milk, avoid during lactation or use with caution after consulting a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Available in pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Patent Expired
Clinical Trials
Phase III trials demonstrated non-inferiority to standard treatments for targeted infections. Further post-marketing surveillance is ongoing.
Lab Monitoring
- Renal function tests (e.g., Creatinine clearance) for patients with renal impairment
- INR for patients on warfarin
- ECG monitoring in patients at risk of QT prolongation
Doctor Notes
- Advise patients about potential tendon issues and to report any pain immediately.
- Consider alternative antibiotics for patients with a history of cardiac arrhythmias due to QT prolongation risk.
- Educate on the importance of completing the full course.
Patient Guidelines
- Complete the full course of treatment even if symptoms improve.
- Stay well-hydrated.
- Avoid excessive sun exposure.
- Report any tendon pain or unusual sensations immediately.
Missed Dose Advice
If a dose is missed, take it as soon as remembered. If it is almost time for the next dose, skip the missed dose and continue with the regular schedule. Do not double the dose.
Driving Precautions
May cause dizziness or visual disturbances; exercise caution when driving or operating machinery.
Lifestyle Advice
- Maintain good hygiene to prevent reinfection.
- Follow a balanced diet.
- Avoid alcohol during treatment.
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