Benmet
Generic Name
Metformin Hydrochloride
Manufacturer
Reputable Pharmaceutical Company
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| benmet 400 mg tablet | ৳ 1.70 | ৳ 17.00 |
Description
Overview of the medicine
Benmet 400 mg Tablet contains Metformin Hydrochloride, an oral antidiabetic medication used to manage type 2 diabetes mellitus. It helps to lower blood glucose levels by reducing glucose production in the liver, decreasing intestinal absorption of glucose, and improving insulin sensitivity.
Uses & Indications
Dosage
Adults
Initial dose is typically 500 mg once or twice daily, or 850 mg once daily with meals. May be titrated up to a maximum of 2000-2550 mg daily in divided doses. For a 400 mg tablet (which is an unusual strength), patients might start with 400 mg once or twice daily and increase gradually as advised by a physician.
Elderly
Dose should be carefully titrated based on renal function, starting with a lower dose to minimize risk of lactic acidosis. Renal function should be monitored more frequently.
Renal_impairment
Contraindicated in severe renal impairment (eGFR < 30 mL/min/1.73 m²). Dose reduction required for moderate impairment (eGFR 30-60 mL/min/1.73 m²), with frequent monitoring of renal function.
How to Take
Take orally with meals to reduce gastrointestinal side effects. Swallow tablets whole with water, do not crush or chew.
Mechanism of Action
Metformin primarily acts by decreasing hepatic glucose production (gluconeogenesis) and intestinal absorption of glucose. It also improves insulin sensitivity by increasing peripheral glucose uptake and utilization. It does not stimulate insulin secretion, thus posing a lower risk of hypoglycemia compared to sulfonylureas.
Pharmacokinetics
Onset
Initial glucose lowering effect within hours, full effect typically within 1-2 weeks.
Excretion
Primarily excreted unchanged in the urine. Renal clearance is approximately 3.5 times higher than creatinine clearance.
Half life
Approximately 4-9 hours (plasma elimination half-life).
Absorption
Bioavailability of Metformin is approximately 50-60% after an oral dose. Food can decrease the extent and slightly delay the absorption.
Metabolism
Metformin is not metabolized by the liver in humans.
Side Effects
Contraindications
- •Severe renal impairment (eGFR < 30 mL/min/1.73 m²)
- •Acute or chronic metabolic acidosis, including diabetic ketoacidosis, with or without coma
- •Hypersensitivity to metformin hydrochloride
- •Acute or chronic disease that may cause tissue hypoxia (e.g., cardiac failure, respiratory failure, recent myocardial infarction, shock)
- •Severe hepatic impairment, acute alcohol intoxication.
Drug Interactions
Alcohol
Potentiates the effect of metformin on lactate metabolism and increases the risk of lactic acidosis.
Contrast Agents (iodinated)
Temporarily discontinue Metformin before or at the time of an iodinated contrast imaging procedure and for at least 48 hours after, and restart only after renal function is re-evaluated and found to be normal.
Diuretics (thiazide and loop)
Can cause hyperglycemia and may reduce metformin efficacy.
Carbonic Anhydrase Inhibitors (e.g., topiramate, acetazolamide)
May increase risk of lactic acidosis.
Drugs that reduce metformin clearance (e.g., cimetidine, ranolazine, dolutegravir)
May increase metformin plasma levels and risk of lactic acidosis.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Overdose of Metformin can lead to lactic acidosis, which is a medical emergency. Symptoms include malaise, myalgia, respiratory distress, increased somnolence, and abdominal distress. Treatment is supportive, focusing on correcting acidosis and removing metformin, often via hemodialysis.
Pregnancy & Lactation
Pregnancy Category B. Generally, insulin is preferred for glycemic control during pregnancy. Metformin can be considered in specific cases under strict medical supervision. Small amounts excreted into breast milk, but generally considered compatible with breastfeeding; consult a physician.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months
Availability
Pharmacies, hospitals, and clinics
Approval Status
Approved by major regulatory bodies (e.g., FDA, DGDA)
Patent Status
Generic available
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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