Betanol
Generic Name
Atenolol
Manufacturer
Popular Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| betanol 25 mg tablet | ৳ 0.45 | ৳ 4.50 |
| betanol 50 mg tablet | ৳ 0.77 | ৳ 7.70 |
| betanol 100 mg tablet | ৳ 1.37 | ৳ 13.70 |
Description
Overview of the medicine
Betanol (Atenolol) is a beta-blocker medicine used to treat high blood pressure, angina (chest pain), irregular heartbeats, and to prevent further heart attacks.
Uses & Indications
Dosage
Adults
Hypertension: Initially 25-50 mg once daily, increasing to 100 mg if necessary. Angina: 50-100 mg once daily. Arrhythmias: 50-100 mg once daily. Acute Myocardial Infarction: 50 mg orally, 12 hours after IV dose, then 100 mg once daily.
Elderly
Lower doses may be required, particularly in those with impaired renal function. Start with 25 mg once daily.
Renal_impairment
Creatinine clearance 15-35 mL/min: 50 mg once daily. Creatinine clearance <15 mL/min: 25 mg once daily or 50 mg every other day.
How to Take
Take orally, with or without food, usually once daily. Swallow the tablet whole with water.
Mechanism of Action
Atenolol selectively blocks beta-1 adrenergic receptors, primarily in the heart. This reduces heart rate, cardiac output, and blood pressure by decreasing the force of heart muscle contraction and the speed of electrical conduction in the heart.
Pharmacokinetics
Onset
Oral: ~1 hour.
Excretion
Primarily excreted unchanged by the kidneys (approx. 50% within 24 hours).
Half life
6-7 hours, can be prolonged in renal impairment.
Absorption
Incompletely absorbed from the gastrointestinal tract; approximately 50% of an oral dose is absorbed.
Metabolism
Minimal hepatic metabolism; less than 10% is metabolized.
Side Effects
Contraindications
- Sinus bradycardia
- Second or third-degree atrioventricular block
- Cardiogenic shock
- Overt cardiac failure
- Bronchial asthma or bronchospasm
- Untreated pheochromocytoma
- Metabolic acidosis
Drug Interactions
Digoxin
Increased risk of bradycardia.
Clonidine
If discontinuing concomitant clonidine, withdraw atenolol several days before tapering clonidine.
Insulin/Oral Hypoglycemics
May mask symptoms of hypoglycemia and potentiate hypoglycemic effects.
NSAIDs (e.g., Indomethacin)
May reduce the antihypertensive effects of atenolol.
Calcium Channel Blockers (e.g., Verapamil, Diltiazem)
May enhance bradycardia and heart block, use with caution.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include severe bradycardia, hypotension, acute cardiac failure, and bronchospasm. Treatment is symptomatic and supportive. May involve atropine for bradycardia, glucagon, IV fluids, and vasopressors for hypotension, and bronchodilators for bronchospasm.
Pregnancy & Lactation
Pregnancy Category D: Atenolol should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is excreted in breast milk and may cause adverse effects in a nursing infant. Use with caution during lactation.
Side Effects
Contraindications
- Sinus bradycardia
- Second or third-degree atrioventricular block
- Cardiogenic shock
- Overt cardiac failure
- Bronchial asthma or bronchospasm
- Untreated pheochromocytoma
- Metabolic acidosis
Drug Interactions
Digoxin
Increased risk of bradycardia.
Clonidine
If discontinuing concomitant clonidine, withdraw atenolol several days before tapering clonidine.
Insulin/Oral Hypoglycemics
May mask symptoms of hypoglycemia and potentiate hypoglycemic effects.
NSAIDs (e.g., Indomethacin)
May reduce the antihypertensive effects of atenolol.
Calcium Channel Blockers (e.g., Verapamil, Diltiazem)
May enhance bradycardia and heart block, use with caution.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include severe bradycardia, hypotension, acute cardiac failure, and bronchospasm. Treatment is symptomatic and supportive. May involve atropine for bradycardia, glucagon, IV fluids, and vasopressors for hypotension, and bronchodilators for bronchospasm.
Pregnancy & Lactation
Pregnancy Category D: Atenolol should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is excreted in breast milk and may cause adverse effects in a nursing infant. Use with caution during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Available in all pharmacies and hospitals in Bangladesh
Approval Status
DGDA approved (Bangladesh)
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established the efficacy and safety of atenolol in treating hypertension, angina, and post-myocardial infarction.
Lab Monitoring
- Blood pressure monitoring
- Heart rate monitoring
- Renal function tests (especially in elderly or renally impaired patients)
Doctor Notes
- Monitor heart rate and blood pressure regularly.
- Caution in patients with obstructive airway disease, diabetes, and peripheral vascular disease.
- Educate patients on the importance of gradual withdrawal.
Patient Guidelines
- Take Betanol exactly as prescribed by your doctor.
- Do not stop taking Betanol abruptly, as it may worsen your condition.
- Inform your doctor about any existing medical conditions, especially asthma, heart failure, or kidney problems.
- Report any unusual side effects to your doctor.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Betanol may cause dizziness or fatigue, especially at the start of treatment. Patients should be cautious when driving or operating machinery until they know how Betanol affects them.
Lifestyle Advice
- Maintain a healthy diet low in sodium and saturated fats.
- Engage in regular physical activity as advised by your doctor.
- Avoid smoking and limit alcohol consumption.
- Manage stress effectively.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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