Betapro
Generic Name
Propranolol Hydrochloride
Manufacturer
Popular Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| betapro 10 mg tablet | ৳ 16.00 | ৳ 160.00 |
Description
Overview of the medicine
Betapro 10 mg Tablet contains Propranolol Hydrochloride, a non-selective beta-blocker. It is used to treat various conditions including high blood pressure, angina, irregular heartbeats, anxiety, migraine, and essential tremor.
Uses & Indications
Dosage
Adults
Typical starting dose for hypertension or angina is 40 mg twice daily, increasing as needed. For anxiety or migraine prophylaxis, 10-20 mg two to three times daily.
Elderly
Lower initial doses may be required, titrate carefully based on response and tolerability.
Renal_impairment
No significant dose adjustment needed for mild to moderate renal impairment; monitor carefully in severe cases.
How to Take
Take orally with water, preferably before meals. Do not crush or chew the tablet. Maintain a consistent dosing schedule.
Mechanism of Action
Propranolol non-selectively blocks beta-1 and beta-2 adrenergic receptors. This blockade reduces heart rate, myocardial contractility, and cardiac output, leading to a decrease in blood pressure. It also inhibits renin release and has anti-anxiety and anti-migraine effects by acting on the central nervous system.
Pharmacokinetics
Onset
Approximately 30 minutes to 1 hour (oral)
Excretion
Primarily excreted via the kidneys (urine) as metabolites.
Half life
3-6 hours
Absorption
Rapid and almost complete absorption from the gastrointestinal tract, but undergoes significant first-pass metabolism.
Metabolism
Extensively metabolized in the liver (mainly via CYP2D6 and CYP1A2) to active and inactive metabolites.
Side Effects
Contraindications
- Bronchial asthma or bronchospasm
- Cardiogenic shock
- Sinus bradycardia (slow heart rate)
- Second or third-degree heart block (without a pacemaker)
- Severe hypotension
- Uncontrolled heart failure
Drug Interactions
NSAIDs
May reduce the antihypertensive effects of propranolol.
Epinephrine
Paradoxical hypertension and bradycardia may occur.
Antidiabetic drugs
May mask symptoms of hypoglycemia.
Calcium Channel Blockers (e.g., Verapamil, Diltiazem)
Increased risk of bradycardia and hypotension.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include severe bradycardia, hypotension, bronchospasm, and acute cardiac failure. Treatment is supportive, including atropine for bradycardia, vasopressors for hypotension, and bronchodilators for bronchospasm.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. Excreted in breast milk; caution advised, monitor infant for beta-blockade effects.
Side Effects
Contraindications
- Bronchial asthma or bronchospasm
- Cardiogenic shock
- Sinus bradycardia (slow heart rate)
- Second or third-degree heart block (without a pacemaker)
- Severe hypotension
- Uncontrolled heart failure
Drug Interactions
NSAIDs
May reduce the antihypertensive effects of propranolol.
Epinephrine
Paradoxical hypertension and bradycardia may occur.
Antidiabetic drugs
May mask symptoms of hypoglycemia.
Calcium Channel Blockers (e.g., Verapamil, Diltiazem)
Increased risk of bradycardia and hypotension.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include severe bradycardia, hypotension, bronchospasm, and acute cardiac failure. Treatment is supportive, including atropine for bradycardia, vasopressors for hypotension, and bronchodilators for bronchospasm.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. Excreted in breast milk; caution advised, monitor infant for beta-blockade effects.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months from manufacturing date
Availability
Pharmacies, hospitals
Approval Status
Approved by major regulatory bodies (e.g., FDA, DGDA)
Patent Status
Expired (Generic available)
WHO Essential Medicine
YesClinical Trials
Extensively studied in numerous clinical trials demonstrating efficacy in hypertension, angina, arrhythmias, and other indications. Modern trials focus on new formulations or specific patient populations.
Lab Monitoring
- Blood pressure monitoring
- Heart rate monitoring
- Blood glucose (especially in diabetics)
- Renal function (periodically)
Doctor Notes
- Counsel patients on gradual withdrawal to avoid rebound effects.
- Carefully assess patients with a history of asthma or COPD.
- Monitor heart rate and blood pressure regularly.
- Be aware of potential drug interactions, especially with other cardiovascular agents.
Patient Guidelines
- Do not stop taking this medicine suddenly without consulting your doctor.
- Inform your doctor about all other medications you are taking.
- Report any unusual side effects immediately.
- Avoid alcohol consumption while on this medication, as it may increase dizziness.
- Diabetic patients should monitor blood sugar levels closely, as propranolol can mask symptoms of hypoglycemia.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
May cause dizziness, fatigue, or blurred vision. Exercise caution when driving or operating machinery until you know how this medicine affects you.
Lifestyle Advice
- Maintain a healthy diet and regular exercise.
- Reduce salt intake if for hypertension.
- Avoid smoking.
- Manage stress effectively.
Alternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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