Betapro
Generic Name
Metoprolol Tartrate 25 mg Tablet
Manufacturer
Hypothetical Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| betapro 25 mg tablet | ৳ 6.00 | ৳ 60.00 |
Description
Overview of the medicine
Betapro-25 mg Tablet contains Metoprolol Tartrate, a beta-blocker primarily used to treat high blood pressure, angina, and certain heart rhythm disorders. It works by relaxing blood vessels and slowing heart rate, improving blood flow and reducing blood pressure.
Uses & Indications
Dosage
Adults
Hypertension: Initially 50-100 mg daily in 1 or 2 divided doses. Angina: 50-100 mg twice daily. The 25mg dose is often used for initial titration or specific conditions.
Elderly
Similar to adult dosage, but caution with initial lower doses due to potential for increased sensitivity and reduced elimination.
Renal_impairment
No dosage adjustment usually required for mild to moderate renal impairment. Use with caution in severe impairment.
How to Take
Take orally, usually with or immediately after a meal to increase absorption and reduce gastric irritation. Do not crush or chew the tablet.
Mechanism of Action
Metoprolol is a cardioselective beta-1 adrenergic blocking agent. It selectively blocks beta-1 receptors in the heart, reducing heart rate, myocardial contractility, and cardiac output. At higher doses, it may also block beta-2 receptors.
Pharmacokinetics
Onset
Within 1 hour (oral)
Excretion
Mainly excreted in urine as metabolites, with a small portion as unchanged drug.
Half life
3-7 hours
Absorption
Rapid and complete absorption from the GI tract (approx. 95%), but undergoes significant first-pass metabolism, leading to a bioavailability of about 50%.
Metabolism
Extensively metabolized by the liver, primarily via CYP2D6.
Side Effects
Contraindications
- Sinus bradycardia
- Second or third-degree heart block
- Cardiogenic shock
- Decompensated heart failure
- Sick sinus syndrome (unless a pacemaker is in place)
- Severe peripheral arterial disease
Drug Interactions
Digoxin
Increased risk of bradycardia.
Other antihypertensives
Additive hypotensive effects.
NSAIDs (e.g., Ibuprofen)
May reduce the hypotensive effect of beta-blockers.
Calcium channel blockers (e.g., Verapamil, Diltiazem)
Increased risk of bradycardia and AV block.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include severe bradycardia, hypotension, cardiac insufficiency, bronchospasm, and cardiac arrest. Management involves gastric lavage, activated charcoal, and symptomatic supportive care (e.g., atropine for bradycardia, vasopressors for hypotension, glucagon, or pacemaking).
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. Metoprolol is excreted in breast milk; caution advised during lactation.
Side Effects
Contraindications
- Sinus bradycardia
- Second or third-degree heart block
- Cardiogenic shock
- Decompensated heart failure
- Sick sinus syndrome (unless a pacemaker is in place)
- Severe peripheral arterial disease
Drug Interactions
Digoxin
Increased risk of bradycardia.
Other antihypertensives
Additive hypotensive effects.
NSAIDs (e.g., Ibuprofen)
May reduce the hypotensive effect of beta-blockers.
Calcium channel blockers (e.g., Verapamil, Diltiazem)
Increased risk of bradycardia and AV block.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include severe bradycardia, hypotension, cardiac insufficiency, bronchospasm, and cardiac arrest. Management involves gastric lavage, activated charcoal, and symptomatic supportive care (e.g., atropine for bradycardia, vasopressors for hypotension, glucagon, or pacemaking).
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. Metoprolol is excreted in breast milk; caution advised during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Usually 2-3 years from manufacturing date.
Availability
Pharmacies, hospitals, clinics
Approval Status
Approved by regulatory authorities (e.g., FDA, DGDA)
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established the efficacy and safety of Metoprolol for its approved indications, demonstrating significant reductions in cardiovascular events and mortality.
Lab Monitoring
- Blood pressure
- Heart rate
- ECG
- Renal function (periodically)
Doctor Notes
- Counsel patients on the importance of gradual withdrawal.
- Monitor heart rate and blood pressure, especially in elderly or renally impaired patients.
- Be aware of potential drug interactions with other cardiovascular medications.
Patient Guidelines
- Take as directed by your doctor.
- Do not stop taking this medication abruptly without consulting your doctor.
- Report any unusual side effects, especially severe dizziness or slow heart rate.
- Monitor your blood pressure and heart rate regularly if advised.
Missed Dose Advice
If you miss a dose, take it as soon as you remember, unless it is almost time for your next dose. In that case, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
May cause dizziness or fatigue, especially at the start of treatment or after dosage changes. Avoid driving or operating machinery until you know how this medicine affects you.
Lifestyle Advice
- Adopt a healthy diet low in sodium and saturated fats.
- Engage in regular physical activity as advised by your doctor.
- Avoid smoking and excessive alcohol consumption.
- Manage stress effectively.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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