Adults

Apply a thin layer to the affected skin area 2-3 times daily, or as directed by a physician. Gently rub in.

Elderly

Same as adults; use with caution for prolonged periods or on large areas due to potential for increased systemic absorption.

Renal_impairment

Not typically a concern for topical application; however, in cases of extensive and prolonged use, systemic absorption may occur, requiring caution.

Onset

Symptomatic relief usually begins within a few days of application.

Excretion

Absorbed betamethasone and its metabolites are excreted primarily via the kidneys. Unabsorbed neomycin is excreted unchanged in feces.

Half life

Systemic half-life of absorbed betamethasone is generally hours. For topical neomycin, systemic half-life is not clinically significant due to poor absorption.

Absorption

Minimal systemic absorption of both betamethasone and neomycin occurs through intact skin; absorption is increased with inflamed or damaged skin, prolonged use, and occlusive dressings.

Metabolism

Absorbed betamethasone is primarily metabolized in the liver. Neomycin is poorly absorbed and primarily excreted unchanged.

Systemic drugs

Systemic drug interactions are unlikely due to minimal topical absorption. However, with prolonged use over large areas, systemic absorption of betamethasone could theoretically interact with drugs affecting corticosteroid metabolism (e.g., CYP3A4 inhibitors).

Other topical preparations

Avoid concurrent use with other topical corticosteroids or antibiotics on the same area unless advised by a doctor, to prevent additive effects or interactions.