Bevixa
Generic Name
Bevacizumab
Manufacturer
XYZ Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| bevixa 100 mg injection | ৳ 20,000.00 | N/A |
Description
Overview of the medicine
Bevixa 100 mg Injection is an anti-cancer medication used to treat various types of cancer by inhibiting the growth of new blood vessels that feed tumors.
Uses & Indications
Dosage
Adults
Typically 5 mg/kg, 7.5 mg/kg, 10 mg/kg, or 15 mg/kg given intravenously every 2 or 3 weeks, depending on the specific cancer type and treatment regimen.
Elderly
No specific dose adjustment required based on age, but close monitoring for adverse effects is recommended.
Renal_impairment
No specific dose adjustment required; use with caution.
How to Take
Intravenous infusion over 30-90 minutes, usually administered by a healthcare professional.
Mechanism of Action
Bevacizumab selectively binds to and neutralizes Vascular Endothelial Growth Factor (VEGF), preventing its interaction with receptors on endothelial cells. This inhibits angiogenesis, thereby starving tumors of their blood supply and limiting their growth and metastasis.
Pharmacokinetics
Onset
Rapid, with anti-angiogenic effects observable within hours to days.
Excretion
Not specifically renally or hepatically excreted in an unchanged form; degradation products are excreted via normal physiological pathways.
Half life
Approximately 17 to 21 days (range 11-50 days).
Absorption
Administered intravenously, hence 100% bioavailability.
Metabolism
Primarily catabolized by proteolytic degradation throughout the body, similar to endogenous IgG; not metabolized by cytochrome P450 enzymes.
Side Effects
Contraindications
- Hypersensitivity to bevacizumab or any excipient
- Pregnancy and breastfeeding
- Severe bleeding
- Recent arterial thromboembolic event
Drug Interactions
Sunitinib
Increased risk of microangiopathic hemolytic anemia.
Recent surgery
Increased risk of wound healing complications.
Chemotherapeutic agents
Increased risk of myelosuppression and gastrointestinal perforation.
Platinum-based chemotherapy
Increased risk of neutropenia.
Storage
Store refrigerated at 2°C to 8°C (36°F to 46°F). Do not freeze. Protect from light. Do not shake.
Overdose
No specific antidote. Treatment is supportive and symptomatic.
Pregnancy & Lactation
Contraindicated in pregnancy due to potential fetal harm. Avoid breastfeeding during treatment and for at least 6 months after the last dose.
Side Effects
Contraindications
- Hypersensitivity to bevacizumab or any excipient
- Pregnancy and breastfeeding
- Severe bleeding
- Recent arterial thromboembolic event
Drug Interactions
Sunitinib
Increased risk of microangiopathic hemolytic anemia.
Recent surgery
Increased risk of wound healing complications.
Chemotherapeutic agents
Increased risk of myelosuppression and gastrointestinal perforation.
Platinum-based chemotherapy
Increased risk of neutropenia.
Storage
Store refrigerated at 2°C to 8°C (36°F to 46°F). Do not freeze. Protect from light. Do not shake.
Overdose
No specific antidote. Treatment is supportive and symptomatic.
Pregnancy & Lactation
Contraindicated in pregnancy due to potential fetal harm. Avoid breastfeeding during treatment and for at least 6 months after the last dose.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from manufacturing date.
Availability
Hospital pharmacies, specialized oncology centers
Approval Status
Approved
Patent Status
Expired in many regions (biosimilars available)
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have demonstrated efficacy and safety across multiple cancer types. Ongoing trials continue to explore new indications and combinations.
Lab Monitoring
- Blood pressure monitoring
- Urinalysis for proteinuria
- Complete blood count (CBC)
- Renal function tests
- Liver function tests
- Coagulation parameters
Doctor Notes
- Monitor blood pressure and urine protein levels closely before, during, and after therapy.
- Counsel patients on potential for bleeding, arterial thromboembolic events, and GI perforation.
- Ensure proper wound healing prior to initiation, and hold therapy before and after major surgery.
- Adjust dose or discontinue based on adverse events.
Patient Guidelines
- Report any unusual bleeding or bruising immediately
- Report severe headache or vision changes
- Maintain good hydration
- Adhere to scheduled appointments and laboratory tests
- Do not self-administer the injection
Missed Dose Advice
Contact your doctor immediately for instructions. Do not double the next dose.
Driving Precautions
May cause fatigue, headache, or vision changes; caution advised if experiencing these symptoms. Avoid driving or operating heavy machinery if affected.
Lifestyle Advice
- Avoid strenuous activities that may lead to injury or bleeding
- Discuss any planned surgeries with your doctor well in advance
- Maintain a balanced diet and healthy lifestyle
- Avoid smoking and excessive alcohol consumption
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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