Bevixa
Generic Name
Bevacizumab
Manufacturer
Hypothetical Pharma Co. Ltd.
Country
Global
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| bevixa 400 mg injection | ৳ 75,000.00 | N/A |
Description
Overview of the medicine
Bevacizumab is a recombinant humanized monoclonal antibody that selectively binds to and neutralizes Vascular Endothelial Growth Factor (VEGF-A), thereby inhibiting angiogenesis and tumor growth.
Uses & Indications
Dosage
Adults
Typically 5-15 mg/kg intravenously every 2-3 weeks, depending on indication and concomitant therapy. Administered as an infusion over 30-90 minutes.
Elderly
No specific dosage adjustment required for elderly patients based on age alone.
Renal_impairment
No specific dosage adjustment recommended for patients with renal impairment.
How to Take
Administered as an intravenous infusion by a healthcare professional. Initial infusion over 90 minutes, subsequent infusions may be shortened to 60 or 30 minutes if well tolerated.
Mechanism of Action
Bevacizumab selectively binds to and inhibits the biological activity of human VEGF-A, preventing its interaction with VEGF receptors (Flt-1 and KDR) on the surface of endothelial cells. This inhibits new blood vessel formation (angiogenesis) that tumors need to grow.
Pharmacokinetics
Onset
Not immediately measurable in terms of clinical effect; takes several weeks for anti-angiogenic effects.
Excretion
Mainly via catabolism; not renally or hepatically cleared in a major way.
Half life
Approximately 20 days (range 11-50 days).
Absorption
Administered intravenously, hence 100% bioavailability.
Metabolism
Degraded via proteolytic catabolism like endogenous IgG.
Side Effects
Contraindications
- Known hypersensitivity to bevacizumab or any excipient
- Severe bleeding or recent significant hemorrhage
- Uncontrolled hypertension
- Recent major surgery or unhealed wounds
Drug Interactions
Sunitinib
Increased risk of microangiopathic hemolytic anemia with Bevacizumab.
Platinum-based and taxane chemotherapies
Increased risk of neutropenia and other myelosuppression, though specific interactions are not consistently demonstrated.
Storage
Store refrigerated at 2°C to 8°C (36°F to 46°F) in original carton to protect from light. Do not freeze. Do not shake.
Overdose
No specific antidote for overdose. Management should involve supportive measures and close monitoring for adverse reactions.
Pregnancy & Lactation
Pregnancy Category D. May cause fetal harm. Avoid during pregnancy. Advise women of reproductive potential to use effective contraception. Not recommended during breastfeeding due to potential for serious adverse reactions in the infant.
Side Effects
Contraindications
- Known hypersensitivity to bevacizumab or any excipient
- Severe bleeding or recent significant hemorrhage
- Uncontrolled hypertension
- Recent major surgery or unhealed wounds
Drug Interactions
Sunitinib
Increased risk of microangiopathic hemolytic anemia with Bevacizumab.
Platinum-based and taxane chemotherapies
Increased risk of neutropenia and other myelosuppression, though specific interactions are not consistently demonstrated.
Storage
Store refrigerated at 2°C to 8°C (36°F to 46°F) in original carton to protect from light. Do not freeze. Do not shake.
Overdose
No specific antidote for overdose. Management should involve supportive measures and close monitoring for adverse reactions.
Pregnancy & Lactation
Pregnancy Category D. May cause fetal harm. Avoid during pregnancy. Advise women of reproductive potential to use effective contraception. Not recommended during breastfeeding due to potential for serious adverse reactions in the infant.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months when stored under recommended conditions.
Availability
Hospitals, Specialized Cancer Treatment Centers
Approval Status
FDA Approved
Patent Status
Patent expired; biosimilars available
WHO Essential Medicine
YesClinical Trials
Extensively studied in numerous Phase III trials across various solid tumors. Ongoing trials explore new combinations and indications.
Lab Monitoring
- Blood pressure monitoring
- Urine protein (dipstick or 24-hour collection)
- Complete Blood Count (CBC)
- Renal function tests (Creatinine)
- Electrolytes
Doctor Notes
- Counsel patients on potential serious adverse events, including perforation, hemorrhage, and thromboembolism.
- Emphasize strict blood pressure control throughout treatment.
- Regularly monitor for proteinuria and surgical complications.
Patient Guidelines
- Report any unusual bleeding, severe headache, vision changes, or severe abdominal pain immediately.
- Do not self-administer; must be given by a healthcare professional.
- Inform your doctor about all other medications and supplements you are taking.
Missed Dose Advice
Contact your doctor or healthcare provider immediately if a dose is missed. They will advise on rescheduling.
Driving Precautions
Bevacizumab may cause fatigue, headache, or visual disturbances. Patients should be advised to exercise caution when driving or operating machinery if they experience these effects.
Lifestyle Advice
- Maintain a healthy diet and lifestyle.
- Closely monitor blood pressure if you have hypertension.
- Avoid activities that may increase risk of bleeding or injury.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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