Medicine Information

Bilasi

Name: Bilasi
Brand: Bilasi
Rating: 4.5 (117 reviews)

Tablet20 mgProton Pump Inhibitor (PPI)ATC: A02BC05

Generic Name

Esomeprazole Magnesium Trihydrate

Manufacturer

Popular Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
bilasi 20 mg tablet	৳ 15.00	৳ 150.00

Description

Overview of the medicine

Bilasi 20 mg Tablet contains Esomeprazole, a proton pump inhibitor used to reduce stomach acid production. It treats conditions like GERD, ulcers, and Zollinger-Ellison syndrome.

Uses & Indications

Gastro-oesophageal Reflux Disease (GERD)

Erosive esophagitis

Zollinger-Ellison syndrome

Duodenal ulcers associated with H. pylori

Prevention of NSAID-associated gastric ulcers

Dosage

Adults

GERD: 20-40 mg once daily for 4-8 weeks. Erosive esophagitis: 20-40 mg once daily for 4-8 weeks. H. pylori eradication: 20 mg twice daily with antibiotics.

Elderly

No specific dose adjustment is required for elderly patients.

Renal_impairment

No dose adjustment needed for mild to moderate renal impairment. For severe impairment, caution is advised.

How to Take

Take the tablet whole with a glass of water, at least one hour before a meal. Do not chew or crush.

Mechanism of Action

Esomeprazole specifically inhibits the H+/K+-ATPase enzyme system (the proton pump) at the secretory surface of the gastric parietal cells, thereby blocking the final step of acid production.

Pharmacokinetics

Onset

Within 1 hour

Excretion

Mainly excreted in urine (approximately 80%) and feces (approximately 20%) as metabolites.

Half life

Approximately 1.5 hours

Absorption

Rapidly absorbed after oral administration, bioavailability is approximately 64% for 20 mg dose.

Metabolism

Extensively metabolized in the liver by the cytochrome P450 (CYP) enzyme system, particularly CYP2C19 and CYP3A4.

Side Effects

Contraindications

Hypersensitivity to esomeprazole or any components of the formulation
Concomitant use with nelfinavir

Drug Interactions

Warfarin

Increased INR/prothrombin time; monitor closely.

Clopidogrel

Reduced antiplatelet effect of clopidogrel due to CYP2C19 inhibition.

Ketoconazole, Itraconazole

Reduced absorption of drugs requiring acidic gastric pH for absorption.

Storage

Store below 30°C in a dry place, away from light and moisture.

Overdose

Symptoms may include nausea, vomiting, abdominal pain, diarrhea, and headache. Treatment is symptomatic and supportive. Gastric lavage may be considered.

Pregnancy & Lactation

Use during pregnancy only if clearly needed after consulting a doctor. Avoid during breastfeeding.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 tablets per strip30 tablets per box

Shelf Life

36 months

Availability

Pharmacies nationwide

Approval Status

Approved by DGDA

Patent Status

Patent Expired (Generic available)

WHO Essential Medicine

Yes

Clinical Trials

Extensively studied in numerous clinical trials for GERD, ulcer healing, and H. pylori eradication.

Lab Monitoring

Magnesium levels (with prolonged use)
Vitamin B12 levels (with prolonged use)
Liver function tests (if liver impairment suspected)

Doctor Notes

Consider lowest effective dose for shortest duration.
Monitor for signs of C. difficile-associated diarrhea.
Counsel patients on potential long-term risks.

Patient Guidelines

Take as directed by your doctor.
Do not stop taking without consulting your doctor.
Report any severe or persistent side effects.

Missed Dose Advice

If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.