Bizoran
Generic Name
Bizoran
Manufacturer
MediCorp Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| bizoran 10 mg tablet | ৳ 22.00 | ৳ 330.00 |
Description
Overview of the medicine
Bizoran 10 mg Tablet is an anxiolytic medication used to relieve symptoms of anxiety disorders. It works by affecting certain chemical messengers in the brain to produce a calming effect.
Uses & Indications
Dosage
Adults
Initially 5 mg once daily, increasing to 10 mg daily as a single dose or divided doses. Max 20 mg/day.
Elderly
Initiate with a lower dose, e.g., 5 mg once daily, adjusting cautiously based on response and tolerability.
Renal_impairment
No specific dosage adjustment guidance, but caution is advised. Consider starting with lower doses.
How to Take
Take orally with or without food. Swallow the tablet whole with water. Do not crush or chew.
Mechanism of Action
Bizoran is thought to modulate gamma-aminobutyric acid (GABA) receptors in the central nervous system, enhancing GABAergic neurotransmission. This leads to a reduction in neuronal excitability, producing an anxiolytic, sedative, and muscle relaxant effect.
Pharmacokinetics
Onset
Anxiolytic effects typically begin within 30-60 minutes.
Excretion
Mainly excreted in urine as metabolites; a small amount excreted in feces.
Half life
Approximately 10-20 hours, allowing for once or twice daily dosing.
Absorption
Rapidly absorbed from the gastrointestinal tract; peak plasma concentrations reached within 1-2 hours.
Metabolism
Primarily metabolized in the liver via oxidative pathways, producing inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to Bizoran or any component of the tablet
- Severe respiratory insufficiency
- Acute narrow-angle glaucoma
- Severe liver impairment
Drug Interactions
CYP3A4 Inducers (e.g., rifampicin, carbamazepine)
May decrease Bizoran plasma concentrations, reducing its efficacy.
CYP3A4 Inhibitors (e.g., ketoconazole, erythromycin)
May increase Bizoran plasma concentrations, leading to enhanced effects and side effects.
CNS Depressants (e.g., alcohol, opioids, other anxiolytics)
Increased sedative effects and respiratory depression risk.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include severe drowsiness, confusion, slow reflexes, and possibly respiratory depression or coma. Treatment is primarily supportive; maintain airway, monitor vital signs, and provide symptomatic care. There is no specific antidote.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit outweighs risk. Not recommended during breastfeeding due to potential excretion into breast milk.
Side Effects
Contraindications
- Hypersensitivity to Bizoran or any component of the tablet
- Severe respiratory insufficiency
- Acute narrow-angle glaucoma
- Severe liver impairment
Drug Interactions
CYP3A4 Inducers (e.g., rifampicin, carbamazepine)
May decrease Bizoran plasma concentrations, reducing its efficacy.
CYP3A4 Inhibitors (e.g., ketoconazole, erythromycin)
May increase Bizoran plasma concentrations, leading to enhanced effects and side effects.
CNS Depressants (e.g., alcohol, opioids, other anxiolytics)
Increased sedative effects and respiratory depression risk.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include severe drowsiness, confusion, slow reflexes, and possibly respiratory depression or coma. Treatment is primarily supportive; maintain airway, monitor vital signs, and provide symptomatic care. There is no specific antidote.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit outweighs risk. Not recommended during breastfeeding due to potential excretion into breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date.
Availability
Available in pharmacies nationwide
Approval Status
Approved by DGDA (hypothetical)
Patent Status
Patent expired
Clinical Trials
Clinical trials demonstrated efficacy in reducing anxiety symptoms with a favorable safety profile. Further post-marketing studies are ongoing.
Lab Monitoring
- Liver function tests (periodically during long-term therapy)
- Renal function tests (for patients with renal impairment)
Doctor Notes
- Educate patients on the risk of dependence and importance of gradual tapering.
- Advise against co-administration with alcohol or other CNS depressants.
- Monitor for paradoxical reactions, especially in elderly patients.
Patient Guidelines
- Do not stop taking Bizoran abruptly; withdrawal symptoms may occur. Consult your doctor for gradual dose reduction.
- Avoid alcohol and other CNS depressants while on this medication.
- Inform your doctor about all other medications you are taking.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Bizoran may cause drowsiness or dizziness. Avoid driving or operating heavy machinery until you know how this medicine affects you.
Lifestyle Advice
- Practice stress-reducing techniques like meditation or yoga.
- Ensure adequate sleep and a balanced diet.
- Avoid excessive caffeine intake.
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