Bizoran
Generic Name
Olanzapine
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| bizoran 5 mg tablet | ৳ 20.00 | ৳ 300.00 |
Description
Overview of the medicine
Olanzapine (Bizoran) is an atypical antipsychotic medication used to treat schizophrenia and bipolar disorder. It helps to restore the balance of certain natural substances (neurotransmitters) in the brain.
Uses & Indications
Dosage
Adults
Schizophrenia: Initially 10 mg once daily, target dose 10-15 mg/day. Bipolar mania: Initially 10-15 mg once daily (monotherapy) or 10 mg once daily (combination), target 5-20 mg/day.
Elderly
Lower initial dose (e.g., 5 mg/day) and slower titration may be considered, especially if risk factors for hypotension are present.
Renal_impairment
No specific dose adjustment is routinely required; however, caution is advised in severe renal impairment.
How to Take
Take Bizoran-5mg tablet orally, once daily, with or without food. Swallow the tablet whole with water. Do not crush or chew.
Mechanism of Action
Olanzapine acts as an antagonist at multiple receptor sites, including dopamine D2, serotonin 5-HT2A, alpha1-adrenergic, histamine H1, and muscarinic M1 receptors. This broad receptor binding profile contributes to its antipsychotic and mood-stabilizing effects.
Pharmacokinetics
Onset
Therapeutic effects for schizophrenia/bipolar disorder develop over days to weeks. Rapid onset of action for acute agitation.
Excretion
Approximately 57% excreted in urine and 30% in feces, primarily as inactive metabolites.
Half life
Mean half-life is 21-54 hours (average 33 hours).
Absorption
Well absorbed orally, reaching peak plasma concentrations in 5-8 hours. Bioavailability is not affected by food.
Metabolism
Primarily hepatic metabolism via direct glucuronidation and cytochrome P450 (CYP1A2 and CYP2D6).
Side Effects
Contraindications
- Known hypersensitivity to olanzapine or any component of the formulation.
- Patients with narrow-angle glaucoma.
Drug Interactions
Fluvoxamine
May increase olanzapine plasma levels due to CYP1A2 inhibition.
Carbamazepine
May decrease olanzapine plasma levels due to enzyme induction.
Antihypertensives
May enhance hypotensive effects.
Alcohol/CNS Depressants
May have additive CNS depressant effects.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include tachycardia, agitation, dysarthria, various extrapyramidal symptoms, and decreased consciousness (ranging from sedation to coma). Management is primarily supportive, including maintaining an open airway, oxygenation, and ventilation.
Pregnancy & Lactation
Pregnancy Category C (risk cannot be ruled out). Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Not recommended during breastfeeding due to excretion in milk.
Side Effects
Contraindications
- Known hypersensitivity to olanzapine or any component of the formulation.
- Patients with narrow-angle glaucoma.
Drug Interactions
Fluvoxamine
May increase olanzapine plasma levels due to CYP1A2 inhibition.
Carbamazepine
May decrease olanzapine plasma levels due to enzyme induction.
Antihypertensives
May enhance hypotensive effects.
Alcohol/CNS Depressants
May have additive CNS depressant effects.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include tachycardia, agitation, dysarthria, various extrapyramidal symptoms, and decreased consciousness (ranging from sedation to coma). Management is primarily supportive, including maintaining an open airway, oxygenation, and ventilation.
Pregnancy & Lactation
Pregnancy Category C (risk cannot be ruled out). Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Not recommended during breastfeeding due to excretion in milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from the date of manufacture, specific details on packaging.
Availability
Pharmacies, hospitals
Approval Status
Approved
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Olanzapine has been extensively studied in numerous randomized, placebo-controlled clinical trials for its efficacy and safety in schizophrenia and bipolar disorder across various populations.
Lab Monitoring
- Regular monitoring of blood glucose levels (fasting and HbA1c)
- Lipid profile (cholesterol, triglycerides)
- Weight and BMI
- Liver function tests (LFTs)
- Prolactin levels (if symptomatic)
Doctor Notes
- Prior to initiation, assess patient's metabolic risk factors (glucose, lipids, weight).
- Monitor for emergence of tardive dyskinesia and Neuroleptic Malignant Syndrome (NMS).
- Use with caution in patients with cardiovascular disease, history of seizures, or conditions that predispose to hypotension.
- Educate patients on potential side effects, particularly weight gain and metabolic changes.
Patient Guidelines
- Do not stop taking Bizoran-5mg abruptly without consulting your doctor, as this can lead to withdrawal symptoms or worsening of your condition.
- Report any unusual side effects, especially uncontrollable movements, excessive thirst, or increased urination, to your doctor promptly.
- Avoid alcohol consumption while taking this medication.
- Take the medication exactly as prescribed by your doctor.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and take your next dose at the regular time. Do not double the dose to catch up.
Driving Precautions
Bizoran-5mg may cause drowsiness, dizziness, or blurred vision. Avoid driving or operating heavy machinery until you know how this medication affects you.
Lifestyle Advice
- Maintain a healthy diet and engage in regular physical activity to help manage potential weight gain.
- Monitor blood sugar levels if you have a history of diabetes or risk factors for it.
- Report any thoughts of self-harm or suicide to a healthcare professional immediately.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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