BPCare
Generic Name
Valsartan
Manufacturer
Acme Laboratories Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| bpcare 160 mg tablet | ৳ 17.50 | ৳ 175.00 |
Description
Overview of the medicine
BPCare 160 mg Tablet contains Valsartan, an angiotensin receptor blocker, used to treat high blood pressure (hypertension) and heart failure. It helps to widen blood vessels, making it easier for your heart to pump blood.
Uses & Indications
Dosage
Adults
Hypertension: Initially 80 mg once daily, may be increased to 160 mg or 320 mg daily. Heart Failure: Initially 40 mg twice daily, titrated up to 160 mg twice daily as tolerated.
Elderly
No special dosage adjustment is required in elderly patients with normal renal function.
Renal_impairment
No dosage adjustment is required for patients with mild to moderate renal impairment. For severe impairment, caution is advised.
How to Take
Take orally once or twice daily with or without food. Swallow the tablet whole with water.
Mechanism of Action
Valsartan selectively blocks the binding of angiotensin II to the AT1 receptor in many tissues, including vascular smooth muscle and the adrenal gland. This inhibits the vasoconstrictive and aldosterone-secreting effects of angiotensin II, leading to vasodilation and reduced blood pressure.
Pharmacokinetics
Onset
Antihypertensive effect within 2 hours.
Excretion
Primarily excreted unchanged in feces (about 83%) and urine (about 13%).
Half life
Approximately 6 hours.
Absorption
Rapidly absorbed after oral administration. Absolute bioavailability is approximately 23%.
Metabolism
Minimally metabolized; only about 20% is metabolized to an inactive metabolite.
Side Effects
Contraindications
- Hypersensitivity to valsartan or any component of the formulation
- Pregnancy (especially second and third trimesters)
- Concomitant use with aliskiren in patients with diabetes or renal impairment
- Severe hepatic impairment, biliary cirrhosis, and cholestasis
Drug Interactions
Lithium
Increased serum lithium concentrations and toxicity.
Aliskiren
Increased risk of hypotension, hyperkalemia, and renal impairment in patients with diabetes or renal impairment.
NSAIDs (Nonsteroidal anti-inflammatory drugs)
May reduce the antihypertensive effect and increase the risk of renal impairment.
Potassium-sparing diuretics (e.g., Spironolactone) / Potassium supplements
May lead to hyperkalemia.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include marked hypotension and dizziness. Treatment is symptomatic and supportive, including intravenous fluid administration for hypotension. Valsartan is not removed by hemodialysis.
Pregnancy & Lactation
Valsartan is contraindicated in pregnancy, especially in the second and third trimesters, due to risk of fetal injury or death. It is not known if valsartan is excreted in human milk, so caution should be exercised when administered to a nursing mother.
Side Effects
Contraindications
- Hypersensitivity to valsartan or any component of the formulation
- Pregnancy (especially second and third trimesters)
- Concomitant use with aliskiren in patients with diabetes or renal impairment
- Severe hepatic impairment, biliary cirrhosis, and cholestasis
Drug Interactions
Lithium
Increased serum lithium concentrations and toxicity.
Aliskiren
Increased risk of hypotension, hyperkalemia, and renal impairment in patients with diabetes or renal impairment.
NSAIDs (Nonsteroidal anti-inflammatory drugs)
May reduce the antihypertensive effect and increase the risk of renal impairment.
Potassium-sparing diuretics (e.g., Spironolactone) / Potassium supplements
May lead to hyperkalemia.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include marked hypotension and dizziness. Treatment is symptomatic and supportive, including intravenous fluid administration for hypotension. Valsartan is not removed by hemodialysis.
Pregnancy & Lactation
Valsartan is contraindicated in pregnancy, especially in the second and third trimesters, due to risk of fetal injury or death. It is not known if valsartan is excreted in human milk, so caution should be exercised when administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Pharmacies, Hospitals
Approval Status
Approved by FDA and DGDA
Patent Status
Generic available (Patent expired)
Clinical Trials
Valsartan has been evaluated in numerous clinical trials for hypertension, heart failure, and post-myocardial infarction. Key trials include VALIANT (Valsartan in Acute Myocardial Infarction Trial) and Val-HeFT (Valsartan Heart Failure Trial).
Lab Monitoring
- Serum potassium levels
- Renal function (creatinine, BUN)
- Blood pressure monitoring
Doctor Notes
- Monitor blood pressure and renal function regularly.
- Advise patients about symptoms of hyperkalemia and angioedema.
- Avoid use in pregnant patients.
- Consider combination therapy if monotherapy is insufficient for blood pressure control.
Patient Guidelines
- Take medicine regularly as prescribed by your doctor.
- Do not stop taking BPCare without consulting your doctor.
- Inform your doctor if you experience swelling of face, lips, or throat (angioedema).
- Avoid potassium supplements or salt substitutes containing potassium without medical advice.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
BPCare may cause dizziness or fatigue, especially at the start of treatment or when the dose is changed. If affected, do not drive or operate machinery.
Lifestyle Advice
- Maintain a healthy diet low in sodium.
- Engage in regular physical activity.
- Avoid smoking and excessive alcohol consumption.
- Monitor your blood pressure regularly.
Alternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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