Brezofil
Generic Name
Fenspiride Hydrochloride
Manufacturer
XYZ Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| brezofil 100 mg syrup | ৳ 100.00 | N/A |
Description
Overview of the medicine
Brezofil 100 mg Syrup is an anti-inflammatory and bronchodilator medicine used to treat respiratory conditions like chronic bronchitis and asthma. It helps in reducing inflammation and relaxing the muscles around the airways, making breathing easier.
Uses & Indications
Dosage
Adults
100 mg (as per prescribed volume of syrup) twice daily, or as directed by the physician. Maximum dose generally 300 mg/day.
Elderly
Dosage adjustment may be required based on renal function; generally, start with lower doses.
Renal_impairment
Use with caution. Dosage reduction may be necessary. Not recommended in severe renal impairment.
How to Take
Administer orally. Can be taken with or without food. Measure the dose accurately using a measuring cup or spoon provided.
Mechanism of Action
Fenspiride acts as an anti-inflammatory agent and a bronchodilator. Its mechanism involves antagonism of H1 histamine receptors, inhibition of alpha1-adrenergic receptors, and modulation of inflammatory mediators like prostaglandins and leukotrienes, reducing bronchoconstriction and inflammation in the airways.
Pharmacokinetics
Onset
Therapeutic effects may be observed within a few days of regular administration.
Excretion
Mainly excreted via the kidneys (urine), with some fecal excretion.
Half life
Approximately 12 hours (elimination half-life).
Absorption
Well absorbed orally, with peak plasma concentrations achieved within 2-4 hours.
Metabolism
Extensively metabolized, primarily in the liver, into inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to Fenspiride or any component of the syrup
- History of cardiac arrhythmias or risk factors for QT prolongation
- Children under 2 years (due to respiratory depression risk)
Drug Interactions
CNS depressants
May enhance the sedative effects when used with alcohol or other CNS depressants.
QT-prolonging drugs
Concurrent use with other drugs known to prolong the QT interval (e.g., antiarrhythmics, some antipsychotics, macrolide antibiotics) may increase the risk of cardiac arrhythmias.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, nausea, vomiting, tachycardia, and potentially cardiac arrhythmias. Treatment is symptomatic and supportive, including gastric lavage and monitoring of cardiac function (ECG).
Pregnancy & Lactation
Not recommended during pregnancy or lactation due to insufficient data on safety. Consult a doctor.
Side Effects
Contraindications
- Hypersensitivity to Fenspiride or any component of the syrup
- History of cardiac arrhythmias or risk factors for QT prolongation
- Children under 2 years (due to respiratory depression risk)
Drug Interactions
CNS depressants
May enhance the sedative effects when used with alcohol or other CNS depressants.
QT-prolonging drugs
Concurrent use with other drugs known to prolong the QT interval (e.g., antiarrhythmics, some antipsychotics, macrolide antibiotics) may increase the risk of cardiac arrhythmias.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, nausea, vomiting, tachycardia, and potentially cardiac arrhythmias. Treatment is symptomatic and supportive, including gastric lavage and monitoring of cardiac function (ECG).
Pregnancy & Lactation
Not recommended during pregnancy or lactation due to insufficient data on safety. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from manufacturing date.
Availability
Pharmacies, Hospitals
Approval Status
Approved by local drug authorities (e.g., DGDA, regulatory bodies in specific countries where it is available)
Patent Status
Patent expired
Clinical Trials
Clinical trials primarily focused on its efficacy in reducing inflammation and bronchoconstriction in respiratory diseases, and more recently, on its cardiac safety profile.
Lab Monitoring
- ECG monitoring (especially in patients with risk factors for QT prolongation)
- Liver and renal function tests (in prolonged therapy)
Doctor Notes
- Carefully assess cardiac risk factors before prescribing.
- Advise patients on potential cardiac side effects and to seek immediate medical attention if symptoms occur.
- Consider alternative therapies with better safety profiles if available.
Patient Guidelines
- Follow the prescribed dosage and duration.
- Report any signs of cardiac issues (palpitations, dizziness) immediately.
- Do not stop the medication without consulting your doctor.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
May cause drowsiness or dizziness. Avoid driving or operating heavy machinery until you know how this medicine affects you.
Lifestyle Advice
- Avoid smoking to improve respiratory health.
- Maintain good hydration.
- Avoid alcohol while taking this medicine.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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