Brezofil
Generic Name
Brezoxil Hydrochloride
Manufacturer
PharmaCorp Bangladesh Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| brezofil 200 mg tablet | ৳ 8.00 | ৳ 80.00 |
Description
Overview of the medicine
Brezofil 200 mg Tablet is a non-steroidal anti-inflammatory drug (NSAID) used for the relief of mild to moderate pain, inflammation, and fever.
Uses & Indications
Dosage
Adults
One 200 mg tablet 2-3 times daily, or as directed by physician. Max 600 mg/day.
Elderly
Lower doses may be required, closely monitor for adverse effects.
Renal_impairment
Use with caution; dose adjustment may be necessary in severe impairment.
How to Take
Take orally, preferably with food or milk to minimize gastrointestinal upset.
Mechanism of Action
Brezoxil Hydrochloride works by inhibiting the activity of cyclooxygenase (COX-1 and COX-2) enzymes, which are responsible for the synthesis of prostaglandins, mediators of pain, inflammation, and fever.
Pharmacokinetics
Onset
Within 30-60 minutes.
Excretion
Mainly excreted via the kidneys (urine) as metabolites, with a small portion in feces.
Half life
Approximately 2-4 hours.
Absorption
Rapidly and completely absorbed from the gastrointestinal tract.
Metabolism
Primarily metabolized in the liver by oxidation and glucuronidation.
Side Effects
Contraindications
- Hypersensitivity to Brezoxil Hydrochloride or other NSAIDs
- Active peptic ulcer or gastrointestinal bleeding
- Severe renal or hepatic impairment
- Third trimester of pregnancy
- Severe heart failure
Drug Interactions
Methotrexate
Increased methotrexate toxicity.
Corticosteroids
Increased risk of gastrointestinal ulceration and bleeding.
Diuretics and ACE inhibitors
Reduced efficacy of these drugs and increased risk of renal impairment.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include nausea, vomiting, abdominal pain, lethargy, dizziness, and drowsiness. Management is symptomatic and supportive. Gastric lavage and activated charcoal may be considered if taken recently.
Pregnancy & Lactation
Not recommended during the third trimester of pregnancy due to potential fetal harm. Use with caution during lactation as it may pass into breast milk; consult a doctor.
Side Effects
Contraindications
- Hypersensitivity to Brezoxil Hydrochloride or other NSAIDs
- Active peptic ulcer or gastrointestinal bleeding
- Severe renal or hepatic impairment
- Third trimester of pregnancy
- Severe heart failure
Drug Interactions
Methotrexate
Increased methotrexate toxicity.
Corticosteroids
Increased risk of gastrointestinal ulceration and bleeding.
Diuretics and ACE inhibitors
Reduced efficacy of these drugs and increased risk of renal impairment.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include nausea, vomiting, abdominal pain, lethargy, dizziness, and drowsiness. Management is symptomatic and supportive. Gastric lavage and activated charcoal may be considered if taken recently.
Pregnancy & Lactation
Not recommended during the third trimester of pregnancy due to potential fetal harm. Use with caution during lactation as it may pass into breast milk; consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date
Availability
Pharmacies and Hospitals
Approval Status
Approved by DGDA
Patent Status
Patent expired
Clinical Trials
Clinical trials have demonstrated the efficacy of Brezoxil Hydrochloride in reducing pain and inflammation in patients with various musculoskeletal conditions, showing comparable results to established NSAIDs.
Lab Monitoring
- Renal function tests (creatinine, BUN) for long-term use
- Liver function tests (ALT, AST) periodically
- Complete blood count (CBC) for prolonged therapy
Doctor Notes
- Prescribe the lowest effective dose for the shortest possible duration.
- Monitor patients for signs of GI bleeding or cardiovascular events, especially in high-risk individuals.
- Assess renal function regularly during long-term therapy.
Patient Guidelines
- Take with food or milk to reduce stomach upset.
- Do not exceed the recommended dose.
- Inform your doctor about any pre-existing medical conditions or other medications.
- Report any unusual bleeding or stomach pain immediately.
Missed Dose Advice
If a dose is missed, take it as soon as remembered. If it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness or drowsiness; caution is advised when driving or operating machinery.
Lifestyle Advice
- Avoid alcohol consumption while taking this medicine.
- Stay well hydrated by drinking plenty of fluids.
- Maintain a balanced diet.
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Global Brand Names
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