Broket
Generic Name
Broket 1 mg Tablet
Manufacturer
Innovate Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| broket 1 mg tablet | ৳ 3.00 | ৳ 30.00 |
Description
Overview of the medicine
Broket 1 mg Tablet is an anxiolytic medication used for the short-term management of anxiety disorders and insomnia. It helps to calm the brain and nerves.
Uses & Indications
Dosage
Adults
General anxiety: 0.5-1 mg, 2-3 times daily. Insomnia: 1-2 mg at bedtime. Panic disorder: 1-2 mg, 2-3 times daily, may be increased up to 6 mg daily in divided doses.
Elderly
Initially 0.25-0.5 mg, 2-3 times daily. Titrate cautiously to minimize side effects.
Renal_impairment
No specific dosage adjustment guidance, use with caution. Consider lower doses if severe impairment.
How to Take
Take the tablet whole with water, with or without food. Do not chew or crush. Follow your doctor's instructions carefully.
Mechanism of Action
Broket selectively binds to specific sites on the GABA-A receptor complex, enhancing the inhibitory effects of GABA. This leads to hyperpolarization of neurons and reduced neuronal excitability, resulting in anxiolytic, sedative, and muscle relaxant effects.
Pharmacokinetics
Onset
Within 30-60 minutes after oral administration.
Excretion
Excreted mainly in the urine as metabolites, with a small amount in feces.
Half life
Approximately 10-20 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract; peak plasma concentrations reached within 1-2 hours.
Metabolism
Primarily metabolized in the liver via oxidative pathways, producing inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to Broket or other GABA-A receptor modulators
- Acute narrow-angle glaucoma
- Severe respiratory insufficiency
- Severe hepatic impairment
- Sleep apnea syndrome
Drug Interactions
Cimetidine, Erythromycin, Ketoconazole
May inhibit Broket metabolism, leading to increased plasma levels and effects.
Alcohol and other CNS depressants (e.g., opioids, antidepressants, antihistamines)
Increased sedative effect and risk of respiratory depression.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include somnolence, confusion, impaired coordination, diminished reflexes, and coma. Treatment is primarily supportive; maintain airway, monitor vital signs, and administer intravenous fluids if necessary. Flumazenil may be considered in severe cases, but caution is advised if the patient is on chronic Broket therapy due to precipitation of withdrawal.
Pregnancy & Lactation
Pregnancy Category D. Broket should be avoided during pregnancy due to potential fetal harm, including congenital malformations and withdrawal symptoms in neonates. It is excreted in breast milk and should not be used during lactation.
Side Effects
Contraindications
- Hypersensitivity to Broket or other GABA-A receptor modulators
- Acute narrow-angle glaucoma
- Severe respiratory insufficiency
- Severe hepatic impairment
- Sleep apnea syndrome
Drug Interactions
Cimetidine, Erythromycin, Ketoconazole
May inhibit Broket metabolism, leading to increased plasma levels and effects.
Alcohol and other CNS depressants (e.g., opioids, antidepressants, antihistamines)
Increased sedative effect and risk of respiratory depression.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include somnolence, confusion, impaired coordination, diminished reflexes, and coma. Treatment is primarily supportive; maintain airway, monitor vital signs, and administer intravenous fluids if necessary. Flumazenil may be considered in severe cases, but caution is advised if the patient is on chronic Broket therapy due to precipitation of withdrawal.
Pregnancy & Lactation
Pregnancy Category D. Broket should be avoided during pregnancy due to potential fetal harm, including congenital malformations and withdrawal symptoms in neonates. It is excreted in breast milk and should not be used during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the date of manufacture.
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Generic available
Clinical Trials
Clinical trials have demonstrated the efficacy and safety of Broket in the short-term treatment of anxiety and insomnia across various patient populations. Further long-term studies regarding dependence and cognitive effects are ongoing.
Lab Monitoring
- No routine lab monitoring is generally required. However, liver function tests may be considered with long-term use or in patients with hepatic impairment.
Doctor Notes
- Prescribe Broket for the shortest effective duration possible to minimize the risk of dependence and withdrawal.
- Thoroughly counsel patients on the risks associated with concomitant use of opioids, alcohol, and other CNS depressants.
- Regularly assess the need for continued treatment and monitor for signs of misuse, abuse, or diversion.
Patient Guidelines
- Do not stop taking Broket abruptly; consult your doctor for a gradual dose reduction to avoid withdrawal symptoms.
- Avoid alcohol and other central nervous system depressants while taking this medication.
- Do not share this medication with others, as it is a controlled substance.
Missed Dose Advice
If you miss a dose, take it as soon as you remember, unless it is almost time for your next dose. In that case, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Broket can cause drowsiness, dizziness, and impaired concentration. Avoid driving, operating heavy machinery, or engaging in activities requiring mental alertness until you know how this medication affects you.
Lifestyle Advice
- Practice stress-reducing techniques like meditation or yoga.
- Maintain a regular sleep schedule and ensure a comfortable sleep environment.
- Avoid excessive caffeine intake, especially in the evening.
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Global Brand Names
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