Butapan
Generic Name
Butamirate Citrate
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| butapan 20 mg tablet | ৳ 13.64 | ৳ 136.40 |
Description
Overview of the medicine
Butapan 20 mg Tablet contains Butamirate Citrate, a non-opioid antitussive agent used for the symptomatic treatment of coughs of various etiologies. It helps to reduce the frequency and intensity of cough by acting directly on the cough center.
Uses & Indications
Dosage
Adults
20 mg (1 tablet) three times daily. Max 80 mg/day.
Elderly
Same as adults, but caution for renal/hepatic impairment.
Renal_impairment
No specific dose adjustment required, but use with caution.
How to Take
Tablets should be swallowed whole with water, preferably before meals. Do not chew or crush.
Mechanism of Action
Butamirate Citrate is a central cough suppressant that acts directly on the cough center in the medulla oblongata, without depressing the respiratory center. It also has bronchodilatory and anti-inflammatory effects.
Pharmacokinetics
Onset
Within 30-60 minutes
Excretion
Primarily excreted via the kidneys, mainly as metabolites.
Half life
Approximately 4-6 hours
Absorption
Rapidly and completely absorbed from the gastrointestinal tract after oral administration. Peak plasma concentrations are reached within 1-1.5 hours.
Metabolism
Extensively metabolized by hydrolysis into two main metabolites: 2-phenylbutyric acid and diethylaminoethoxyethanol.
Side Effects
Contraindications
- Hypersensitivity to Butamirate Citrate or any excipients
- Children under 3 years for tablets (age restriction varies by dosage form)
Drug Interactions
Alcohol
May enhance CNS depressant effects, though Butamirate is non-sedating generally.
Cough suppressants (opioids)
Concomitant use with expectorants should be avoided as it may lead to accumulation of bronchial secretions and risk of bronchospasm and infection.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, nausea, vomiting, diarrhea, dizziness, and hypotension. Treatment is symptomatic and supportive. Gastric lavage and activated charcoal may be considered if taken recently.
Pregnancy & Lactation
Use during pregnancy, especially the first trimester, and lactation should be avoided unless clearly necessary and advised by a physician. Consult a doctor before use.
Side Effects
Contraindications
- Hypersensitivity to Butamirate Citrate or any excipients
- Children under 3 years for tablets (age restriction varies by dosage form)
Drug Interactions
Alcohol
May enhance CNS depressant effects, though Butamirate is non-sedating generally.
Cough suppressants (opioids)
Concomitant use with expectorants should be avoided as it may lead to accumulation of bronchial secretions and risk of bronchospasm and infection.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, nausea, vomiting, diarrhea, dizziness, and hypotension. Treatment is symptomatic and supportive. Gastric lavage and activated charcoal may be considered if taken recently.
Pregnancy & Lactation
Use during pregnancy, especially the first trimester, and lactation should be avoided unless clearly necessary and advised by a physician. Consult a doctor before use.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date
Availability
Pharmacies, drugstores
Approval Status
Approved by local regulatory authorities
Patent Status
Generic available, original patent expired
Clinical Trials
Numerous clinical trials have demonstrated its efficacy and safety in various cough etiologies. Ongoing research explores its broader applications.
Lab Monitoring
- No specific lab monitoring required for routine use.
Doctor Notes
- Advise patients to report any worsening of cough or new symptoms.
- Caution in patients with productive cough, as it may hinder expectoration.
- Not for use in children under 3 years for tablet form.
Patient Guidelines
- Do not exceed the recommended dose.
- Consult a doctor if cough persists for more than 7 days or is accompanied by fever, rash, or persistent headache.
- Avoid taking other cough and cold medicines without consulting your doctor.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
May cause drowsiness or dizziness in some individuals; caution is advised when driving or operating machinery until you know how this medicine affects you.
Lifestyle Advice
- Drink plenty of fluids to help thin mucus and soothe the throat.
- Avoid irritants like smoke and dust.
- Get adequate rest.
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