Buterol
Generic Name
Salbutamol (Albuterol) 10 mg tablet
Manufacturer
Generic Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| buterol 10 mg tablet | ৳ 1.51 | ৳ 15.10 |
Description
Overview of the medicine
Buterol 10 mg tablet is a bronchodilator used to relieve symptoms of asthma and chronic obstructive pulmonary disease (COPD) such as coughing, wheezing, and shortness of breath. It works by relaxing the muscles of the airways, making it easier to breathe. This specific 10mg strength is a higher dose and may be used for specific clinical situations or as directed by a physician.
Uses & Indications
Dosage
Adults
The usual oral adult dosage for salbutamol is 2 mg or 4 mg, 3 to 4 times a day. However, for Buterol 10 mg tablet, the exact dosage should be strictly as prescribed by a physician, potentially requiring half a tablet or less frequent administration for specific conditions due to its high strength.
Elderly
A lower initial dose may be considered for elderly patients, such as 2 mg, 3 to 4 times a day, adjusted according to response and tolerability.
Renal_impairment
No specific dosage adjustment is usually required for oral salbutamol, but caution is advised in severe renal impairment. Physician's discretion is recommended.
How to Take
Buterol 10 mg tablet should be taken orally with water, with or without food, as directed by your doctor. Do not crush, chew, or break the tablet unless specifically instructed by your healthcare provider.
Mechanism of Action
Salbutamol is a selective beta-2 adrenergic receptor agonist. It stimulates beta-2 receptors in the smooth muscles of the bronchi, leading to relaxation of the smooth muscles and bronchodilation. This action helps to widen the airways and reduce airway resistance, thereby improving airflow to the lungs.
Pharmacokinetics
Onset
Bronchodilating effect begins within 30 minutes for oral tablets.
Excretion
Mainly excreted in the urine as both unchanged drug and its metabolite, primarily within 72 hours.
Half life
Plasma half-life is approximately 4-6 hours for oral salbutamol.
Absorption
Rapidly absorbed from the gastrointestinal tract following oral administration. Peak plasma concentrations are achieved within 2-3 hours.
Metabolism
Undergoes extensive metabolism in the liver to an inactive sulfate conjugate.
Side Effects
Contraindications
- Hypersensitivity to salbutamol or any component of the formulation
- Patients with uncontrolled hyperthyroidism
- Caution in patients with cardiovascular disorders (e.g., ischemic heart disease, arrhythmia)
Drug Interactions
Digoxin
May decrease serum digoxin levels with concomitant use.
Diuretics (e.g., Furosemide)
May potentiate hypokalemia, particularly with high doses of salbutamol.
Beta-blockers (e.g., Propranolol)
Can block the bronchodilating effect of salbutamol and may cause severe bronchospasm, especially in asthmatic patients.
MAO Inhibitors & Tricyclic Antidepressants
Can potentiate the cardiovascular effects of salbutamol, increasing the risk of arrhythmias.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include tachycardia, palpitation, tremor, headache, dizziness, nausea, vomiting, hypertension or hypotension, and hypokalemia. In severe cases, cardiac arrest and seizures may occur. Treatment is supportive, involving discontinuation of the drug, cardiac monitoring, and correction of electrolyte disturbances (e.g., potassium supplementation for hypokalemia).
Pregnancy & Lactation
Pregnancy Category C: Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is excreted in human milk, so caution should be exercised when administered to a nursing woman.
Side Effects
Contraindications
- Hypersensitivity to salbutamol or any component of the formulation
- Patients with uncontrolled hyperthyroidism
- Caution in patients with cardiovascular disorders (e.g., ischemic heart disease, arrhythmia)
Drug Interactions
Digoxin
May decrease serum digoxin levels with concomitant use.
Diuretics (e.g., Furosemide)
May potentiate hypokalemia, particularly with high doses of salbutamol.
Beta-blockers (e.g., Propranolol)
Can block the bronchodilating effect of salbutamol and may cause severe bronchospasm, especially in asthmatic patients.
MAO Inhibitors & Tricyclic Antidepressants
Can potentiate the cardiovascular effects of salbutamol, increasing the risk of arrhythmias.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include tachycardia, palpitation, tremor, headache, dizziness, nausea, vomiting, hypertension or hypotension, and hypokalemia. In severe cases, cardiac arrest and seizures may occur. Treatment is supportive, involving discontinuation of the drug, cardiac monitoring, and correction of electrolyte disturbances (e.g., potassium supplementation for hypokalemia).
Pregnancy & Lactation
Pregnancy Category C: Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is excreted in human milk, so caution should be exercised when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2-3 years from manufacturing date
Availability
Available in pharmacies, hospitals, and clinics
Approval Status
Approved (Generic)
Patent Status
Patent Expired
WHO Essential Medicine
YesClinical Trials
Salbutamol has been extensively studied since its introduction. Ongoing research focuses on optimizing delivery systems and exploring its potential in new indications, although 10mg oral tablets are not a primary focus for new trials due to higher systemic side effects compared to inhaled forms.
Lab Monitoring
- Serum potassium levels should be monitored, especially in patients receiving high doses, concomitant diuretics, or corticosteroids, due to the risk of hypokalemia.
Doctor Notes
- Educate patients on the proper use of a 10 mg tablet, especially regarding potential splitting if lower doses are required.
- Monitor patients for cardiovascular side effects, particularly those with pre-existing heart conditions.
- Advise patients against increasing the dose or frequency without medical consultation due to the risk of adverse events and worsening asthma control.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor; do not take more or less than recommended.
- Do not stop taking the medicine suddenly without consulting your doctor.
- If your symptoms worsen or you need to use this medication more frequently, contact your doctor immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Buterol may cause tremor, dizziness, or muscle cramps in some individuals. Patients should be advised to exercise caution when driving or operating machinery until they know how the medication affects them.
Lifestyle Advice
- Avoid triggers that worsen your respiratory conditions (e.g., smoke, allergens).
- Maintain a healthy lifestyle, including regular exercise and a balanced diet (if appropriate).
- Stop smoking if you are a smoker, as it significantly worsens respiratory diseases.
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