Buterol
Generic Name
Salbutamol Sulfate Oral Solution
Manufacturer
Hypothetical Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| buterol 5 mg oral solution | ৳ 35.13 | N/A |
Description
Overview of the medicine
Buterol 5 mg Oral Solution contains Salbutamol sulfate, a short-acting beta-2 adrenergic agonist. It is used to relieve symptoms of asthma and chronic obstructive pulmonary disease (COPD) such as coughing, wheezing, and shortness of breath, by relaxing the muscles of the airways.
Uses & Indications
Dosage
Adults
For relief of bronchospasm: 2 to 4 mg (2 to 4 mL of Buterol 5 mg Oral Solution) three or four times daily. Maximum single dose 5 mg (5 mL). Not to exceed 20 mg (20 mL) in 24 hours.
Elderly
Lower initial doses may be considered. Generally, adult dosage applies, but monitor for adverse effects. For relief of bronchospasm: 2 to 4 mg (2 to 4 mL of Buterol 5 mg Oral Solution) three or four times daily. Maximum single dose 5 mg (5 mL). Not to exceed 20 mg (20 mL) in 24 hours.
Renal_impairment
No specific dose adjustment is generally required, but caution is advised in severe renal impairment.
How to Take
Administer orally. The dose can be measured using a measuring spoon or cup. Can be taken with or without food.
Mechanism of Action
Salbutamol selectively stimulates beta-2 adrenergic receptors in bronchial smooth muscle, leading to relaxation of the muscle and bronchodilation. It also inhibits the release of mediators from mast cells in the airways, contributing to its anti-inflammatory effects.
Pharmacokinetics
Onset
Bronchodilation starts within 5-15 minutes.
Excretion
Excreted primarily in the urine as metabolites and unchanged drug.
Half life
Plasma half-life is approximately 4-6 hours.
Absorption
Rapidly and well absorbed from the gastrointestinal tract following oral administration. Peak plasma concentrations are achieved within 2-4 hours.
Metabolism
Undergoes extensive metabolism in the liver to an inactive sulfate conjugate.
Side Effects
Contraindications
- Hypersensitivity to Salbutamol or any component of the formulation
- Tachyarrhythmias
- Severe obstructive cardiomyopathy
Drug Interactions
MAOIs and TCAs
May potentiate the vascular effects of Salbutamol, leading to increased risk of cardiovascular adverse effects.
Diuretics (e.g., Furosemide)
May exacerbate hypokalemia when co-administered with high doses of beta-agonists.
Beta-blockers (e.g., Propranolol)
May diminish the bronchodilator effect of Salbutamol and may cause severe bronchospasm.
Storage
Store below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms include tachycardia, tremors, palpitations, headache, and hypokalemia. Treatment is supportive and symptomatic; consider beta-selective cardioselective blocking agents in severe cases, but with caution due to the risk of bronchospasm.
Pregnancy & Lactation
Use during pregnancy only if the potential benefit outweighs the potential risk to the fetus. Salbutamol is excreted in breast milk; caution is advised when administered to a nursing woman.
Side Effects
Contraindications
- Hypersensitivity to Salbutamol or any component of the formulation
- Tachyarrhythmias
- Severe obstructive cardiomyopathy
Drug Interactions
MAOIs and TCAs
May potentiate the vascular effects of Salbutamol, leading to increased risk of cardiovascular adverse effects.
Diuretics (e.g., Furosemide)
May exacerbate hypokalemia when co-administered with high doses of beta-agonists.
Beta-blockers (e.g., Propranolol)
May diminish the bronchodilator effect of Salbutamol and may cause severe bronchospasm.
Storage
Store below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms include tachycardia, tremors, palpitations, headache, and hypokalemia. Treatment is supportive and symptomatic; consider beta-selective cardioselective blocking agents in severe cases, but with caution due to the risk of bronchospasm.
Pregnancy & Lactation
Use during pregnancy only if the potential benefit outweighs the potential risk to the fetus. Salbutamol is excreted in breast milk; caution is advised when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date
Availability
Pharmacies, hospitals
Approval Status
Approved by regulatory authorities (e.g., FDA, DGDA)
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Numerous clinical trials have established the efficacy and safety of Salbutamol for bronchospasm relief in asthma and COPD.
Lab Monitoring
- Monitor serum potassium levels, especially in patients receiving high doses or concomitant diuretics.
- Monitor heart rate and blood pressure.
Doctor Notes
- Remind patients that Salbutamol is for symptom relief (rescue medication), not for maintenance therapy.
- Educate patients on proper use of the measuring device.
- Advise patients to seek immediate medical attention if they experience chest pain or severe palpitations.
Patient Guidelines
- Follow the prescribed dosage and administration instructions carefully.
- Do not exceed the recommended dose.
- Seek medical attention if symptoms worsen or if the medicine becomes less effective.
- Inform your doctor about all other medications you are taking.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause tremors or dizziness in some patients. Advise caution when driving or operating machinery until effects are known.
Lifestyle Advice
- Avoid smoking, as it can worsen respiratory conditions.
- Maintain good hydration.
- Identify and avoid asthma triggers.
- Regular exercise may improve lung function, but always carry your rescue inhaler if you have exercise-induced asthma.
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