Caldolin
Generic Name
Calcium Carbonate + Vitamin D3
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| caldolin 500 mg tablet | ৳ 7.00 | N/A |
Description
Overview of the medicine
Caldolin is a combination preparation of Calcium Carbonate and Vitamin D3. It is used to prevent and treat calcium and vitamin D deficiencies, particularly in conditions like osteoporosis, rickets, and during pregnancy/lactation.
Uses & Indications
Dosage
Adults
1-2 tablets daily, or as directed by a physician.
Elderly
1-2 tablets daily, or as directed by a physician. Dosage may need adjustment based on renal function.
Renal_impairment
Use with caution. Monitor serum calcium and phosphate levels. Avoid in severe renal impairment.
How to Take
Orally, preferably with or after meals to enhance calcium absorption and minimize gastric upset. Do not chew or crush the tablet; swallow whole with water.
Mechanism of Action
Calcium carbonate provides elemental calcium essential for bone mineralization, muscle contraction, and nerve function. Vitamin D3 (Cholecalciferol) is crucial for regulating calcium and phosphate homeostasis, facilitating their absorption from the gut and deposition into bones.
Pharmacokinetics
Onset
Gradual, effects on bone density are observed over weeks to months.
Excretion
Unabsorbed calcium is excreted via feces. Absorbed calcium is excreted primarily via urine. Vitamin D metabolites are excreted via bile and urine.
Half life
Calcium half-life varies. Vitamin D3's half-life is approximately 2-3 weeks for its active metabolite, calcitriol.
Absorption
Calcium carbonate is absorbed in the small intestine, requiring gastric acid for dissolution. Vitamin D3 is absorbed from the small intestine, primarily in the jejunum, and requires bile salts.
Metabolism
Calcium is not metabolized. Vitamin D3 is hydroxylated in the liver to 25-hydroxyvitamin D3 and then in the kidneys to the active form, 1,25-dihydroxyvitamin D3 (calcitriol).
Side Effects
Contraindications
- •Hypersensitivity to calcium carbonate or vitamin D3
- •Hypercalcemia
- •Hypercalciuria
- •Severe renal impairment
- •Kidney stones (nephrolithiasis)
Drug Interactions
Levothyroxine
Calcium can reduce its absorption; separate doses by at least 4 hours.
Bisphosphonates
Calcium can interfere with their absorption; take calcium after 30 minutes to 2 hours.
Corticosteroids
Reduce calcium absorption.
Iron supplements
Calcium can reduce iron absorption; separate doses by at least 2 hours.
Thiazide diuretics
May increase the risk of hypercalcemia.
Tetracycline and Quinolone antibiotics
Calcium can interfere with their absorption; separate doses by at least 2-3 hours.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose (hypercalcemia) include nausea, vomiting, constipation, abdominal pain, muscle weakness, excessive thirst, polyuria, drowsiness, and in severe cases, cardiac arrhythmias and coma. Management involves discontinuing the product, hydration, and medical supervision.
Pregnancy & Lactation
Caldolin is generally considered safe and beneficial during pregnancy and lactation for meeting increased calcium and vitamin D requirements. However, always consult a physician before use to ensure appropriate dosing.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Pharmacies, drug stores
Approval Status
Approved
Patent Status
Off-patent (Generic components)
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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