Caloprid
Generic Name
Prucalopride
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| caloprid 1 mg tablet | ৳ 14.00 | ৳ 140.00 |
Description
Overview of the medicine
Prucalopride is a selective, high-affinity 5-HT4 receptor agonist used to treat chronic idiopathic constipation in adults. It works by stimulating colonic motility, facilitating bowel movements and improving stool consistency.
Uses & Indications
Dosage
Adults
The recommended dose is 2 mg once daily. For some patients, 1 mg once daily may be sufficient.
Elderly
For patients aged >65 years, initiate treatment with 1 mg once daily. If needed and tolerated, the dose can be increased to 2 mg once daily.
Renal_impairment
For patients with severe renal impairment (creatinine clearance < 30 mL/min), the dose is 1 mg once daily.
How to Take
Administer orally, with or without food, at any time of the day. Swallow the tablet whole with water.
Mechanism of Action
Prucalopride is a selective, high-affinity serotonin (5-HT4) receptor agonist. It stimulates 5-HT4 receptors in the enteric nervous system, leading to increased acetylcholine release and enhanced propulsive colonic motility. This effect helps restore normal gut function and promote bowel movements.
Pharmacokinetics
Onset
Approximately 24-48 hours for significant improvement in bowel movement frequency.
Excretion
Primarily excreted unchanged in urine (about 60-65% of the dose within 24 hours), with some fecal excretion.
Half life
Approximately 24-28 hours.
Absorption
Rapidly absorbed after oral administration; peak plasma concentrations reached within 2-3 hours. Absolute bioavailability is >90%.
Metabolism
Minimally metabolized by hepatic enzymes; primary metabolic pathways involve N-dealkylation and oxidation. No significant metabolism by CYP450 enzymes.
Side Effects
Contraindications
- Hypersensitivity to prucalopride or any of its excipients.
- Intestinal obstruction, inflammatory bowel disease (Crohn's disease, ulcerative colitis), toxic megacolon/megarectum, intestinal perforation.
Drug Interactions
Opioids
May reduce the prokinetic effect of prucalopride, as opioids can cause constipation. Consider higher doses of prucalopride if co-administered.
Ketoconazole, Erythromycin, Ciclosporin
May increase prucalopride plasma concentrations, potentially leading to increased side effects. Exercise caution.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include headache, nausea, and diarrhea. Management is primarily supportive; no specific antidote is available. Gastric lavage and symptomatic treatment may be considered.
Pregnancy & Lactation
Pregnancy Category C. Should only be used during pregnancy if the potential benefit justifies the potential risk to the fetus. Prucalopride is excreted in breast milk; therefore, it is not recommended during breastfeeding.
Side Effects
Contraindications
- Hypersensitivity to prucalopride or any of its excipients.
- Intestinal obstruction, inflammatory bowel disease (Crohn's disease, ulcerative colitis), toxic megacolon/megarectum, intestinal perforation.
Drug Interactions
Opioids
May reduce the prokinetic effect of prucalopride, as opioids can cause constipation. Consider higher doses of prucalopride if co-administered.
Ketoconazole, Erythromycin, Ciclosporin
May increase prucalopride plasma concentrations, potentially leading to increased side effects. Exercise caution.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include headache, nausea, and diarrhea. Management is primarily supportive; no specific antidote is available. Gastric lavage and symptomatic treatment may be considered.
Pregnancy & Lactation
Pregnancy Category C. Should only be used during pregnancy if the potential benefit justifies the potential risk to the fetus. Prucalopride is excreted in breast milk; therefore, it is not recommended during breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date.
Availability
Pharmacies, Hospitals
Approval Status
Approved by regulatory bodies (e.g., FDA, EMA, DGDA)
Patent Status
Generic versions available
Clinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of prucalopride in adult patients with chronic idiopathic constipation, including improvements in spontaneous complete bowel movements.
Lab Monitoring
- No specific routine lab monitoring is required. However, renal function should be assessed before initiating treatment and monitored periodically in patients with severe renal impairment.
Doctor Notes
- Advise patients on the importance of adequate hydration and dietary fiber intake.
- Consider starting with 1 mg dose for elderly patients or those with severe renal impairment.
- Patients with severe cardiovascular disease were excluded from clinical trials; caution is advised in such patients.
- If no improvement after 4 weeks, re-evaluate treatment.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor.
- Do not stop taking the medicine suddenly without consulting your doctor.
- Report any severe or persistent side effects to your healthcare provider.
- Maintain a regular bowel habit and lifestyle.
- This medicine may not work immediately; continue treatment as directed.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose and resume your regular dosing schedule. Do not take two doses at once to make up for a missed dose.
Driving Precautions
Prucalopride may cause dizziness or fatigue. Patients should exercise caution when driving or operating machinery until they know how the medicine affects them.
Lifestyle Advice
- Maintain adequate fluid intake throughout the day.
- Incorporate fiber-rich foods (fruits, vegetables, whole grains) into your diet.
- Engage in regular physical activity to promote bowel regularity.
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Global Brand Names
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