Caloprid
Generic Name
Prucalopride
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| caloprid 2 mg tablet | ৳ 24.00 | ৳ 240.00 |
Description
Overview of the medicine
Caloprid 2 mg Tablet contains Prucalopride, a selective serotonin 5-HT4 receptor agonist, used for the symptomatic treatment of chronic constipation in adults when laxatives fail to provide adequate relief.
Uses & Indications
Dosage
Adults
2 mg once daily. Dosage may be reduced to 1 mg once daily in patients with severe renal impairment.
Elderly
Starting dose of 1 mg once daily may be considered in elderly patients, increasing to 2 mg once daily if needed.
Renal_impairment
Severe renal impairment (CrCl < 30 mL/min): 1 mg once daily. No dosage adjustment needed for mild to moderate renal impairment.
How to Take
Oral administration. Can be taken with or without food, at any time of day.
Mechanism of Action
Prucalopride is a selective, high-affinity 5-hydroxytryptamine 4 (5-HT4) receptor agonist. By stimulating 5-HT4 receptors, it enhances colonic motility and accelerates colonic transit, thereby facilitating bowel movements and relieving chronic constipation.
Pharmacokinetics
Onset
Onset of action typically within 2-3 days, but can vary.
Excretion
Primarily excreted via urine (approximately 60% unchanged drug) and feces (approximately 25%).
Half life
Approximately 24-28 hours.
Absorption
Rapidly absorbed after oral administration. Peak plasma concentrations are reached in 2-3 hours. Absolute bioavailability is >90%.
Metabolism
Extensively metabolized to a small extent; the majority is excreted unchanged. Main metabolite is inactive.
Side Effects
Contraindications
- Hypersensitivity to the active substance or to any of the excipients.
- Intestinal perforation or obstruction.
- Obstructive ileus.
- Severe inflammatory conditions of the intestinal tract such as Crohn's disease and ulcerative colitis.
Drug Interactions
Rifampicin
May decrease prucalopride plasma levels.
Erythromycin
May slightly increase prucalopride plasma levels.
Ketoconazole
May slightly increase prucalopride plasma levels.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Limited experience with overdose. Symptoms may include headache, nausea, and diarrhea. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Not recommended during pregnancy. Should not be used during breastfeeding as prucalopride is excreted into breast milk.
Side Effects
Contraindications
- Hypersensitivity to the active substance or to any of the excipients.
- Intestinal perforation or obstruction.
- Obstructive ileus.
- Severe inflammatory conditions of the intestinal tract such as Crohn's disease and ulcerative colitis.
Drug Interactions
Rifampicin
May decrease prucalopride plasma levels.
Erythromycin
May slightly increase prucalopride plasma levels.
Ketoconazole
May slightly increase prucalopride plasma levels.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Limited experience with overdose. Symptoms may include headache, nausea, and diarrhea. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Not recommended during pregnancy. Should not be used during breastfeeding as prucalopride is excreted into breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date
Availability
Pharmacies, Hospitals
Approval Status
Approved by regulatory authorities (e.g., FDA, EMA, DGDA)
Patent Status
Varies by country; generic versions may be available.
Clinical Trials
Extensive clinical trials have demonstrated prucalopride's efficacy and safety in treating chronic constipation across various patient populations. Studies have shown significant improvements in spontaneous complete bowel movements and stool consistency.
Lab Monitoring
- No specific routine lab monitoring required. Renal function monitoring in patients with severe renal impairment.
Doctor Notes
- Consider prucalopride for chronic constipation refractory to standard laxatives.
- Assess renal function before initiating treatment, especially in elderly patients.
- Counsel patients on potential gastrointestinal side effects (e.g., headache, nausea, diarrhea) which are often transient.
Patient Guidelines
- Take exactly as prescribed by your doctor.
- Do not exceed the recommended dose.
- Inform your doctor if your constipation does not improve or worsens.
- Drink plenty of fluids and maintain a high-fiber diet to aid treatment.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
May cause dizziness and fatigue. Patients should be advised not to drive or operate machinery if affected.
Lifestyle Advice
- Maintain adequate fluid intake.
- Include fiber-rich foods in your diet.
- Engage in regular physical activity.
- Avoid processed foods and excessive caffeine.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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