Calos-D
Generic Name
Calcium Carbonate + Cholecalciferol
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| calos d 500 mg tablet | ৳ 4.00 | N/A |
Description
Overview of the medicine
Used to treat and prevent calcium and vitamin D deficiencies, and as an adjunct in the prevention and treatment of osteoporosis.
Uses & Indications
Dosage
Adults
Typically 1-2 tablets daily, or as directed by physician.
Elderly
Same as adult dose, but caution in renal impairment.
Renal_impairment
Dosage adjustment may be necessary. Use with caution and monitor calcium levels.
How to Take
To be taken orally, preferably with meals to enhance absorption and reduce gastric upset. Chewable tablets should be chewed before swallowing.
Mechanism of Action
Calcium carbonate provides elemental calcium for bone formation and maintenance. Cholecalciferol (Vitamin D3) facilitates the absorption of calcium and phosphate from the intestine and regulates their metabolism.
Pharmacokinetics
Onset
Clinical effects are gradual, not immediate. Bone mineralization takes weeks to months.
Excretion
Calcium is excreted primarily via feces and urine. Vitamin D metabolites are excreted mainly in the bile and feces, with some renal excretion.
Half life
Calcium: Variable, depends on physiological state. Vitamin D3 (Cholecalciferol): Approximately 24 hours in circulation, but stored forms can last for weeks to months.
Absorption
Calcium absorption is primarily in the small intestine, enhanced by Vitamin D. Cholecalciferol is absorbed from the small intestine, mainly in the duodenum and jejunum.
Metabolism
Calcium is not metabolized in the traditional sense. Cholecalciferol is metabolized in the liver to 25-hydroxyvitamin D3, and then in the kidneys to 1,25-dihydroxyvitamin D3 (calcitriol), the active form.
Side Effects
Contraindications
- •Hypersensitivity to any component
- •Hypercalcemia (high calcium levels in blood)
- •Hypervitaminosis D
- •Severe renal impairment or kidney stones
- •Conditions leading to hypercalciuria
Drug Interactions
Levothyroxine
Calcium can reduce absorption. Administer at least 4 hours apart.
Bisphosphonates
Calcium can interfere with absorption. Administer at least 30 minutes apart.
Corticosteroids
May reduce calcium absorption.
Thiazide Diuretics
May increase the risk of hypercalcemia.
Digitalis glycosides
Hypercalcemia increases the risk of digitalis toxicity.
Tetracyclines & Quinolone Antibiotics
Calcium may chelate with these, reducing their absorption. Administer at least 2-3 hours apart.
Storage
Store in a cool, dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include hypercalcemia (nausea, vomiting, constipation, thirst, polyuria, muscle weakness, bone pain, renal calculus). Management involves discontinuation, hydration, and medical supervision.
Pregnancy & Lactation
Calcium and Vitamin D are essential during pregnancy and lactation. This medicine is generally considered safe when taken within recommended doses. Consult a doctor before use.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date.
Availability
Available in pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Generic available
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine
More Medicines
Explore other medicines you might be interested in
