Captabine
Generic Name
Captabine 500 mg Tablet
Manufacturer
PharmaCorp Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| captabine 500 mg tablet | ৳ 90.00 | ৳ 900.00 |
Description
Overview of the medicine
Captabine 500 mg Tablet is a broad-spectrum antibiotic used to treat a wide range of bacterial infections including those of the respiratory tract, urinary tract, and skin.
Uses & Indications
Dosage
Adults
500 mg orally every 12 hours for 7-14 days, depending on the severity and type of infection.
Elderly
No specific dose adjustment is usually required unless there is significant renal impairment. Monitor renal function.
Renal_impairment
For creatinine clearance <30 mL/min, the dose should be reduced to 250 mg every 12 hours or adjusted by a physician.
How to Take
Captabine tablets should be swallowed whole with a glass of water, with or without food. Taking it with food may help minimize gastrointestinal upset.
Mechanism of Action
Captabine inhibits bacterial cell wall synthesis, leading to bacterial cell lysis and death. It exhibits bactericidal activity against susceptible microorganisms.
Pharmacokinetics
Onset
Therapeutic effects typically begin within 1-2 hours of administration.
Excretion
Excreted predominantly by the kidneys, with a smaller portion excreted via bile.
Half life
The elimination half-life is approximately 6-8 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract after oral administration. Peak plasma concentrations are reached within 1-2 hours.
Metabolism
Primarily metabolized in the liver to inactive metabolites.
Side Effects
Contraindications
- •Known hypersensitivity to Captabine, other cephalosporins, or any component of the formulation.
- •History of severe hypersensitivity (e.g., anaphylaxis) to any other beta-lactam antibiotic (e.g., penicillin).
Drug Interactions
Warfarin
May enhance the anticoagulant effect of warfarin, requiring INR monitoring and potential dose adjustment.
Probenecid
Concurrent administration with probenecid may increase and prolong plasma concentrations of Captabine by decreasing its renal tubular secretion.
Oral Contraceptives
Efficacy of oral contraceptives may be reduced; advise additional contraceptive methods.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
In case of overdose, symptomatic and supportive treatment should be initiated. Gastric lavage may be considered if ingestion is recent. Hemodialysis may be useful in accelerating removal from the body.
Pregnancy & Lactation
Captabine should be used during pregnancy only if clearly needed and after careful risk-benefit assessment by a doctor. Small amounts may pass into breast milk; use with caution during lactation, or consider alternative feeding methods.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the date of manufacture when stored under recommended conditions.
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Generic available
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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