Take orally, with or without food, as directed by the physician. It can be taken as a single daily dose or in divided doses.

Methimazole inhibits the synthesis of thyroid hormones by blocking the oxidation of iodine and the coupling of iodotyrosines (monoiodotyrosine and diiodotyrosine) in the thyroid gland, primarily by inhibiting the enzyme thyroid peroxidase.

• •Hypersensitivity to methimazole or other thionamides
• •Severe hepatic impairment
• •History of agranulocytosis or bone marrow depression due to methimazole or carbimazole
• •Pre-existing cholestasis

Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.

Symptoms of overdose may include nausea, vomiting, epigastric distress, headache, fever, arthralgia, pruritus, and pancytopenia. Management involves gastric lavage and symptomatic and supportive treatment. Bone marrow suppression may necessitate granulocyte colony-stimulating factors.

Use with caution. Methimazole crosses the placenta and is secreted into breast milk. It should be used during pregnancy only if clearly needed, at the lowest effective dose. PTU may be preferred in the first trimester, while Methimazole is generally preferred in the second and third trimesters.