Oral administration. Take with or without food. Consistent timing of doses is recommended.

Carbimazole is a pro-drug that is converted to its active metabolite, Methimazole. Methimazole inhibits the synthesis of thyroid hormones by preventing the incorporation of iodine into tyrosine residues on thyroglobulin and by inhibiting the coupling of iodotyrosines to form T3 and T4.

• •Hypersensitivity to carbimazole or methimazole
• •Severe blood disorders (e.g., agranulocytosis)
• •Severe liver impairment
• •Pre-existing cholestasis

Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.

Symptoms include nausea, vomiting, epigastric distress, headache, fever, arthralgia, pruritus, and rarely agranulocytosis, pancytopenia, or hepatitis. Management is supportive, including gastric lavage or activated charcoal if recent. Monitor thyroid function and blood counts.

Pregnancy: Use with caution, lowest effective dose. Crosses the placenta and can cause fetal hypothyroidism and congenital malformations (e.g., aplasia cutis). Lactation: Excreted in breast milk; use with caution, monitor infant thyroid function.