Cardon
Generic Name
Carvedilol
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| cardon 25 mg tablet | ৳ 6.00 | ৳ 60.00 |
Description
Overview of the medicine
Carvedilol is a beta-blocker that also has alpha-blocking activity. It is used to treat high blood pressure, heart failure, and left ventricular dysfunction following a heart attack.
Uses & Indications
Dosage
Adults
Hypertension: Initially 6.25 mg twice daily, may be increased to 12.5 mg twice daily. Maximum 50 mg/day. Heart Failure: Initially 3.125 mg twice daily, gradually increased over at least two-week intervals based on patient tolerance.
Elderly
Similar to adult dosage; careful titration and monitoring for adverse effects is recommended.
Renal_impairment
No dosage adjustment is generally required in patients with renal impairment, but caution is advised and monitor renal function.
How to Take
Administer orally, preferably with food, to slow the rate of absorption and reduce the risk of orthostatic hypotension.
Mechanism of Action
Carvedilol non-selectively blocks beta1 and beta2 adrenergic receptors and selectively blocks alpha1 adrenergic receptors. This results in a reduction in heart rate, myocardial contractility, and peripheral vasodilation, leading to decreased blood pressure.
Pharmacokinetics
Onset
Antihypertensive effect begins within 1 hour; maximal effect within 2-4 hours.
Excretion
Primarily excreted in the feces via bile; a small amount excreted renally.
Half life
Approximately 6-10 hours.
Absorption
Rapidly absorbed after oral administration; bioavailability approximately 25-35% due to extensive first-pass metabolism.
Metabolism
Extensively metabolized in the liver, primarily by CYP2D6 and CYP2C9. Several active metabolites are formed.
Side Effects
Contraindications
- •Known hypersensitivity to carvedilol or any component of the formulation
- •Bronchial asthma or related bronchospastic conditions
- •Second- or third-degree AV block (unless a permanent pacemaker is in place)
- •Sick sinus syndrome (unless a permanent pacemaker is in place)
- •Severe bradycardia (<50 bpm)
- •Decompensated heart failure requiring intravenous inotropic therapy
- •Cardiogenic shock
- •Severe hepatic impairment
Drug Interactions
Digoxin
Increased plasma levels of digoxin when co-administered with carvedilol; monitor digoxin levels.
Rifampin
May decrease carvedilol plasma concentrations, reducing its efficacy.
Insulin and Oral Hypoglycemics
Carvedilol may mask symptoms of hypoglycemia (e.g., tachycardia) and potentiate the blood glucose-lowering effects.
CYP2D6 Inhibitors (e.g., Fluoxetine, Paroxetine)
May increase carvedilol plasma concentrations, enhancing its effects and side effects.
Calcium Channel Blockers (e.g., Verapamil, Diltiazem)
Concomitant use may increase the risk of AV block, bradycardia, and heart failure.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include severe hypotension, bradycardia, cardiac insufficiency, cardiogenic shock, and bronchospasm. Treatment is symptomatic and supportive. Gastric lavage or activated charcoal may be considered. Atropine for bradycardia, glucagon for profound hypotension/heart failure, and beta-sympathomimetics for bronchospasm.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Carvedilol is excreted in human milk; therefore, breastfeeding is not recommended.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months from the date of manufacture, consult package for exact date.
Availability
Pharmacies, hospitals
Approval Status
Approved by regulatory authorities (e.g., FDA, DGDA)
Patent Status
Patent expired, generic versions available
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine
More Medicines
Explore other medicines you might be interested in
