Cardon
Generic Name
Atenolol
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| cardon 50 mg tablet | ৳ 10.00 | ৳ 100.00 |
Description
Overview of the medicine
Cardon 50 mg Tablet contains Atenolol, a beta-blocker primarily used to treat high blood pressure (hypertension), angina (chest pain), and certain types of irregular heartbeats (arrhythmias). It works by reducing the heart rate and the force of heart contractions.
Uses & Indications
Dosage
Adults
Hypertension: Initially 50 mg once daily, may be increased to 100 mg once daily. Angina: Initially 50 mg once daily, may be increased to 100 mg once daily.
Elderly
Lower initial doses may be considered, and dose adjustments are made based on renal function and response.
Renal_impairment
Dosage must be adjusted according to creatinine clearance: CrCl 15-35 mL/min: 50 mg every other day. CrCl <15 mL/min: 50 mg every 4 days.
How to Take
Cardon 50 mg Tablet should be swallowed whole with water, preferably at the same time each day, with or without food. Do not crush or chew the tablet.
Mechanism of Action
Atenolol selectively blocks beta-1 adrenergic receptors, primarily located in the heart. This action leads to a decrease in heart rate, cardiac output, and blood pressure. It also reduces the workload on the heart, making it effective in managing angina and preventing recurrent heart attacks.
Pharmacokinetics
Onset
Within 1 hour (oral)
Excretion
Mainly excreted unchanged by the kidneys (85-100% of the absorbed dose) via glomerular filtration and tubular secretion.
Half life
6-7 hours (can be prolonged in renal impairment)
Absorption
Approximately 50% absorbed from the gastrointestinal tract; peak plasma concentrations occur 2-4 hours post-oral administration.
Metabolism
Minimal hepatic metabolism (<10%); not significantly metabolized by the liver.
Side Effects
Contraindications
- •Sinus bradycardia (very slow heart rate)
- •Second or third-degree heart block
- •Cardiogenic shock
- •Overt cardiac failure
- •Hypotension
- •Metabolic acidosis
- •Severe peripheral arterial disease
Drug Interactions
Clonidine
Risk of rebound hypertension upon abrupt withdrawal of clonidine if Atenolol is not tapered.
Verapamil, Diltiazem
Increased risk of bradycardia, heart block, and hypotension.
NSAIDs (e.g., Ibuprofen)
May reduce the hypotensive effects of Atenolol.
Insulin and oral hypoglycemics
Atenolol may mask symptoms of hypoglycemia (e.g., tachycardia).
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include severe bradycardia, hypotension, acute cardiac failure, and bronchospasm. Treatment is symptomatic and supportive, including gastric lavage, activated charcoal, and IV administration of atropine, glucagon, or beta-adrenergic stimulants as needed.
Pregnancy & Lactation
Pregnancy Category D. Atenolol crosses the placental barrier and has been associated with intrauterine growth restriction and neonatal bradycardia. Should only be used if the potential benefit outweighs the potential risk to the fetus. It is excreted in breast milk and may cause adverse effects in nursing infants; breastfeeding is generally not recommended.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date
Availability
Pharmacies, hospitals, clinics
Approval Status
Approved by FDA/DGDA
Patent Status
Generic available
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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