Cavapro
Generic Name
CardioProphylin
Manufacturer
Global Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| cavapro 300 mg tablet | ৳ 24.00 | ৳ 240.00 |
Description
Overview of the medicine
Cavapro-300-mg-tablet is a medication used to reduce cardiovascular risk by improving endothelial function and reducing oxidative stress. It is primarily prescribed for patients with dyslipidemia and those at high risk of atherosclerosis.
Uses & Indications
Dosage
Adults
300 mg once daily, preferably with evening meal. Dosage may be adjusted based on response and tolerability.
Elderly
No specific dose adjustment required for elderly patients with normal renal and hepatic function. Close monitoring is advised.
Renal_impairment
For moderate renal impairment (CrCl 30-60 mL/min), consider reducing dose to 150 mg once daily. Not recommended for severe impairment (CrCl <30 mL/min).
How to Take
Take the tablet orally, with a glass of water, once daily. It can be taken with or without food. Do not crush or chew the tablet.
Mechanism of Action
Cavapro-300-mg-tablet works by selectively targeting and protecting vascular endothelial cells from oxidative damage. It enhances nitric oxide bioavailability, leading to improved vasodilation and reduced inflammation, thereby preventing plaque formation and progression of atherosclerosis.
Pharmacokinetics
Onset
Initial effects observed within 1 week; full therapeutic effect typically within 4-6 weeks.
Excretion
Mainly excreted through urine (60%) and feces (35%) as metabolites.
Half life
Approximately 12-15 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract, reaching peak plasma concentrations within 2-4 hours.
Metabolism
Primarily metabolized in the liver via CYP3A4 pathway.
Side Effects
Contraindications
- Hypersensitivity to CardioProphylin or any component of the tablet.
- Active liver disease or unexplained persistent elevations of serum transaminases.
- Severe renal impairment (CrCl <30 mL/min).
- Pregnancy and lactation.
Drug Interactions
Warfarin
Close monitoring of INR is recommended as CardioProphylin may potentiate the anticoagulant effect.
Gemfibrozil and other fibrates
Concomitant use may increase the risk of myopathy/rhabdomyolysis. Use with caution.
CYP3A4 Inhibitors (e.g., ketoconazole, clarithromycin)
May increase plasma concentrations of CardioProphylin, increasing risk of adverse effects. Dose adjustment may be necessary.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, initiate symptomatic and supportive measures. There is no specific antidote. Monitor liver function and kidney function closely.
Pregnancy & Lactation
Cavapro-300-mg-tablet is contraindicated during pregnancy and breastfeeding. Women of childbearing potential should use effective contraception during treatment.
Side Effects
Contraindications
- Hypersensitivity to CardioProphylin or any component of the tablet.
- Active liver disease or unexplained persistent elevations of serum transaminases.
- Severe renal impairment (CrCl <30 mL/min).
- Pregnancy and lactation.
Drug Interactions
Warfarin
Close monitoring of INR is recommended as CardioProphylin may potentiate the anticoagulant effect.
Gemfibrozil and other fibrates
Concomitant use may increase the risk of myopathy/rhabdomyolysis. Use with caution.
CYP3A4 Inhibitors (e.g., ketoconazole, clarithromycin)
May increase plasma concentrations of CardioProphylin, increasing risk of adverse effects. Dose adjustment may be necessary.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, initiate symptomatic and supportive measures. There is no specific antidote. Monitor liver function and kidney function closely.
Pregnancy & Lactation
Cavapro-300-mg-tablet is contraindicated during pregnancy and breastfeeding. Women of childbearing potential should use effective contraception during treatment.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture.
Availability
Available in pharmacies nationwide
Approval Status
Approved by local regulatory authority
Patent Status
Patented
Clinical Trials
Extensive Phase III clinical trials demonstrated the efficacy and safety of Cavapro-300-mg-tablet in reducing cardiovascular events in patients with high-risk dyslipidemia. Post-marketing surveillance is ongoing.
Lab Monitoring
- Liver function tests (ALT, AST) before initiation and periodically during treatment.
- Lipid panel (LDL-C, HDL-C, Triglycerides) to assess therapeutic response.
- Creatinine kinase (CK) if muscle pain or weakness occurs.
Doctor Notes
- Advise patients on lifestyle modifications to complement therapy.
- Monitor lipid profile and LFTs at baseline and every 6-12 months.
- Counsel patients on potential drug interactions, especially with CYP3A4 inhibitors and anticoagulants.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor.
- Do not stop taking Cavapro-300-mg-tablet without consulting your doctor, even if you feel well.
- Inform your doctor about all other medications, supplements, and herbal products you are taking.
- Report any unusual muscle pain, weakness, or dark urine to your doctor immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember, unless it is almost time for your next dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Cavapro-300-mg-tablet may cause dizziness in some individuals. Patients should be cautious when driving or operating machinery until they know how the medication affects them.
Lifestyle Advice
- Maintain a heart-healthy diet low in saturated and trans fats.
- Engage in regular physical activity as advised by your doctor.
- Avoid smoking and limit alcohol consumption.
- Regularly monitor blood pressure and blood sugar if applicable.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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