Adults

Adults typically take 500 mg to 1 gram twice daily, depending on the infection. (For suspension, consult a physician for precise dosage).

Elderly

No specific dosage adjustment is generally required for the elderly, but renal function should be monitored.

Renal_impairment

Dosage must be adjusted based on creatinine clearance; an initial dose of 500 mg, followed by maintenance doses at extended intervals (e.g., every 12-36 hours).

Onset

Peak plasma concentrations are usually reached within 1-2 hours after oral administration.

Excretion

Primarily excreted unchanged in the urine by glomerular filtration and tubular secretion. About 90% is eliminated within 24 hours.

Half life

Approximately 1.5 to 2 hours in individuals with normal renal function, increasing significantly with renal impairment.

Absorption

Rapidly and nearly completely absorbed from the gastrointestinal tract, even in the presence of food.

Metabolism

Cefadroxil is minimally metabolized in the body; the majority is excreted unchanged.

Probenecid

May decrease renal tubular secretion of cefadroxil, resulting in increased and prolonged plasma concentrations of cefadroxil.

Aminoglycosides

Concurrent use may increase the risk of nephrotoxicity.

Oral Anticoagulants (e.g., Warfarin)

May enhance the anticoagulant effect by altering gut flora and reducing vitamin K synthesis. INR monitoring is recommended.