Ceftid DS
Generic Name
Ceftriaxone
Manufacturer
Popular Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ceftid ds 200 mg suspension | ৳ 321.21 | N/A |
Description
Overview of the medicine
Ceftid DS contains Ceftriaxone, a third-generation cephalosporin antibiotic used to treat a wide range of bacterial infections. It is administered parenterally.
Uses & Indications
Dosage
Adults
1-2 g intravenously (IV) or intramuscularly (IM) once daily or in two divided doses. Up to 4 g/day in severe cases.
Elderly
No dosage adjustment generally required unless severe renal/hepatic impairment.
Renal_impairment
Dosage adjustment may be necessary in severe renal impairment (creatinine clearance < 10 mL/min).
How to Take
For intramuscular injection, reconstitute with lidocaine. For intravenous injection/infusion, reconstitute with water for injection or compatible IV fluids and administer slowly.
Mechanism of Action
Ceftriaxone inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to bacterial cell lysis and death.
Pharmacokinetics
Onset
Rapid after IV administration, within minutes.
Excretion
Approximately 33-67% excreted unchanged in urine, remaining in bile and feces.
Half life
Approximately 6-9 hours (prolonged in neonates and patients with renal/hepatic impairment).
Absorption
Rapid and complete absorption after intramuscular (IM) administration, bioavailability is 100%. Intravenous (IV) administration provides immediate and complete bioavailability.
Metabolism
Primarily metabolized in the liver to inactive metabolites.
Side Effects
Contraindications
- •Hypersensitivity to ceftriaxone, other cephalosporins, or penicillin
- •Neonates with hyperbilirubinemia
- •Neonates receiving calcium-containing IV solutions
Drug Interactions
Loop diuretics
May increase ceftriaxone levels.
Aminoglycosides
Synergistic effect against some gram-negative bacteria, but must be administered separately.
Oral anticoagulants
May increase the anticoagulant effect.
Calcium-containing solutions
Concomitant use with IV calcium solutions is contraindicated in neonates due to risk of precipitation.
Storage
Store below 30°C, protected from light and moisture. Keep out of reach of children. Reconstituted solution should be used immediately.
Overdose
Symptoms may include nausea, vomiting, diarrhea, and convulsions in severe cases. Management is symptomatic and supportive. Hemodialysis is not effective.
Pregnancy & Lactation
Pregnancy Category B. Use with caution during pregnancy if clearly needed. Excreted in breast milk in small amounts; use with caution during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months (unreconstituted)
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Off-patent
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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