Celipress
Generic Name
Celiprolol
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| celipress 200 mg tablet | ৳ 8.00 | ৳ 80.00 |
Description
Overview of the medicine
Celiprolol is a third-generation beta-blocker primarily used for the treatment of essential hypertension and angina pectoris. It is a hydrophilic, beta-1 selective beta-blocker with intrinsic sympathomimetic activity and alpha-2 adrenergic receptor blocking activity, contributing to its vasodilating properties.
Uses & Indications
Dosage
Adults
Hypertension: Initially 100 mg once daily, adjusted to 200 mg once daily if needed. Maximum 400 mg once daily. Angina: 200 mg to 400 mg once daily.
Elderly
Lower initial doses (e.g., 50 mg or 100 mg once daily) may be considered, with careful titration based on response and tolerability.
Renal_impairment
Dose adjustment required. For creatinine clearance <40 mL/min, the dose should be reduced or the dosing interval prolonged.
How to Take
Take orally, preferably in the morning, with or without food. Swallow the tablet whole with water. Do not crush or chew.
Mechanism of Action
Celiprolol selectively blocks beta-1 adrenergic receptors in the heart, reducing heart rate, cardiac contractility, and cardiac output. Its partial agonist activity provides intrinsic sympathomimetic activity (ISA). Additionally, it has weak alpha-2 adrenergic receptor blocking activity, which contributes to its vasodilating effects and reduction in peripheral vascular resistance.
Pharmacokinetics
Onset
Antihypertensive effect usually evident within 1-2 hours; maximal effect within 2-4 hours.
Excretion
Mainly excreted by the kidneys (60-70% unchanged drug in urine) and partly via feces.
Half life
Elimination half-life is approximately 5-12 hours, which may be prolonged in patients with renal impairment.
Absorption
Incomplete and variable oral absorption, with bioavailability ranging from 30-50%. Peak plasma concentrations are reached in 1-2 hours. Food may variably affect absorption.
Metabolism
Minimally metabolized; primarily excreted unchanged.
Side Effects
Contraindications
- Bronchial asthma or severe chronic obstructive pulmonary disease (COPD)
- Second or third-degree atrioventricular (AV) block
- Sick sinus syndrome (unless a pacemaker is in situ)
- Cardiogenic shock
- Uncontrolled heart failure
- Severe bradycardia (<50 beats/min)
- Untreated pheochromocytoma
- Severe peripheral arterial disease
- Metabolic acidosis
Drug Interactions
Other antihypertensive agents
Additive hypotensive effects.
Insulin and oral hypoglycemics
Celiprolol may mask symptoms of hypoglycemia (e.g., tachycardia).
NSAIDs (Non-steroidal anti-inflammatory drugs)
May reduce the antihypertensive effect of celiprolol.
Calcium channel blockers (Verapamil, Diltiazem)
Increased risk of bradycardia, AV block, and hypotension.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include severe bradycardia, hypotension, acute cardiac insufficiency, and bronchospasm. Management involves symptomatic and supportive measures. Atropine for bradycardia, glucagon for severe cases, vasopressors for hypotension, and bronchodilators for bronchospasm.
Pregnancy & Lactation
Pregnancy Category C. Studies in animals have shown adverse effects on the fetus; there are no adequate and well-controlled studies in pregnant women. Use only if the potential benefit justifies the potential risk to the fetus. Celiprolol is excreted in breast milk; therefore, caution should be exercised when administered to a nursing mother.
Side Effects
Contraindications
- Bronchial asthma or severe chronic obstructive pulmonary disease (COPD)
- Second or third-degree atrioventricular (AV) block
- Sick sinus syndrome (unless a pacemaker is in situ)
- Cardiogenic shock
- Uncontrolled heart failure
- Severe bradycardia (<50 beats/min)
- Untreated pheochromocytoma
- Severe peripheral arterial disease
- Metabolic acidosis
Drug Interactions
Other antihypertensive agents
Additive hypotensive effects.
Insulin and oral hypoglycemics
Celiprolol may mask symptoms of hypoglycemia (e.g., tachycardia).
NSAIDs (Non-steroidal anti-inflammatory drugs)
May reduce the antihypertensive effect of celiprolol.
Calcium channel blockers (Verapamil, Diltiazem)
Increased risk of bradycardia, AV block, and hypotension.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include severe bradycardia, hypotension, acute cardiac insufficiency, and bronchospasm. Management involves symptomatic and supportive measures. Atropine for bradycardia, glucagon for severe cases, vasopressors for hypotension, and bronchodilators for bronchospasm.
Pregnancy & Lactation
Pregnancy Category C. Studies in animals have shown adverse effects on the fetus; there are no adequate and well-controlled studies in pregnant women. Use only if the potential benefit justifies the potential risk to the fetus. Celiprolol is excreted in breast milk; therefore, caution should be exercised when administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from the date of manufacture, specific to manufacturer's label.
Availability
Available in pharmacies and hospitals
Approval Status
Approved in many countries for hypertension and angina. Assumed DGDA approved for Bangladesh.
Patent Status
Off-patent, generic versions available
Clinical Trials
Celiprolol has been evaluated in various clinical trials for its efficacy and safety in hypertension and angina pectoris, demonstrating its role as a vasodilating beta-blocker.
Lab Monitoring
- Regular monitoring of blood pressure and heart rate is essential.
- Renal function (e.g., serum creatinine, eGFR) should be monitored, especially in elderly or renally impaired patients.
Doctor Notes
- Advise patients about the importance of gradual withdrawal to avoid rebound effects.
- Monitor for signs of heart failure exacerbation, especially in patients with pre-existing cardiac conditions.
- Consider dose adjustment in patients with renal impairment.
Patient Guidelines
- Take the medicine regularly as prescribed by your doctor, even if you feel well.
- Do not stop taking celiprolol abruptly without consulting your doctor, as this can worsen your condition.
- Report any unusual or severe side effects to your doctor immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Celiprolol may cause dizziness, fatigue, or visual disturbances in some individuals. Patients should be advised to exercise caution when driving or operating machinery until they know how the drug affects them.
Lifestyle Advice
- Adopt a healthy lifestyle including a balanced diet low in salt and fat, regular exercise, and maintaining a healthy weight.
- Avoid smoking and limit alcohol consumption.
- Stress management techniques may also be beneficial.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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