Celipress
Generic Name
Celipress
Manufacturer
MediCorp Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| celipress 400 mg tablet | ৳ 15.00 | ৳ 150.00 |
Description
Overview of the medicine
Celipress 400 mg Tablet is an Angiotensin II Receptor Blocker (ARB) used to treat high blood pressure (hypertension) and heart failure. It helps to relax blood vessels, allowing blood to flow more easily and thereby lowering blood pressure.
Uses & Indications
Dosage
Adults
The usual starting dose is 200 mg once daily. The dose may be increased to 400 mg once daily depending on blood pressure response. Maximum dose is 800 mg once daily.
Elderly
No initial dose adjustment is generally required in elderly patients, but monitoring of renal function is advised.
Renal_impairment
For patients with moderate to severe renal impairment (creatinine clearance <30 mL/min), a lower starting dose (e.g., 100 mg once daily) may be considered. Close monitoring of renal function is necessary.
How to Take
Celipress 400 mg Tablet should be taken orally, once daily, with or without food. It is recommended to take the tablet at the same time each day.
Mechanism of Action
Celipress selectively blocks the binding of angiotensin II to the AT1 receptor found in many tissues (e.g., vascular smooth muscle, adrenal gland). This blockade inhibits the vasoconstrictive and aldosterone-secreting effects of angiotensin II, leading to vasodilation, decreased systemic vascular resistance, and lower blood pressure.
Pharmacokinetics
Onset
Antihypertensive effect begins within 1-2 hours, with maximal effect observed within 4-6 weeks of therapy.
Excretion
Excreted primarily via the bile (approximately 60%) and urine (approximately 30-40%) as unchanged drug.
Half life
Approximately 10-15 hours, allowing for once-daily dosing.
Absorption
Rapidly absorbed after oral administration, with peak plasma concentrations reached within 1-2 hours. Absolute bioavailability is approximately 40%.
Metabolism
Minimal hepatic metabolism by cytochrome P450 enzymes. Primarily excreted as unchanged drug.
Side Effects
Contraindications
- Hypersensitivity to Celipress or any component of the formulation
- Pregnancy (especially second and third trimesters)
- Concomitant use with aliskiren in patients with diabetes or renal impairment (GFR <60 mL/min/1.73 m²)
- History of angioedema related to previous ARB or ACE inhibitor therapy
Drug Interactions
Lithium
Increased serum lithium concentrations and toxicity. Monitor lithium levels.
NSAIDs (Nonsteroidal Anti-inflammatory Drugs)
May reduce the antihypertensive effect of Celipress and increase the risk of renal impairment. Monitor blood pressure and renal function.
Potassium-sparing diuretics/Potassium supplements
May lead to increased serum potassium levels (hyperkalemia). Monitor serum potassium.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose are likely to include hypotension (low blood pressure) and possibly tachycardia or bradycardia. Treatment is symptomatic and supportive. If ingestion is recent, induce emesis or perform gastric lavage. Intravenous normal saline infusion may be administered to correct hypotension.
Pregnancy & Lactation
Celipress is contraindicated in the second and third trimesters of pregnancy due to risks of fetal injury and death. If pregnancy is detected, discontinue Celipress as soon as possible. It is not known whether Celipress is excreted in human milk, but due to the potential for adverse effects on the nursing infant, a decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.
Side Effects
Contraindications
- Hypersensitivity to Celipress or any component of the formulation
- Pregnancy (especially second and third trimesters)
- Concomitant use with aliskiren in patients with diabetes or renal impairment (GFR <60 mL/min/1.73 m²)
- History of angioedema related to previous ARB or ACE inhibitor therapy
Drug Interactions
Lithium
Increased serum lithium concentrations and toxicity. Monitor lithium levels.
NSAIDs (Nonsteroidal Anti-inflammatory Drugs)
May reduce the antihypertensive effect of Celipress and increase the risk of renal impairment. Monitor blood pressure and renal function.
Potassium-sparing diuretics/Potassium supplements
May lead to increased serum potassium levels (hyperkalemia). Monitor serum potassium.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose are likely to include hypotension (low blood pressure) and possibly tachycardia or bradycardia. Treatment is symptomatic and supportive. If ingestion is recent, induce emesis or perform gastric lavage. Intravenous normal saline infusion may be administered to correct hypotension.
Pregnancy & Lactation
Celipress is contraindicated in the second and third trimesters of pregnancy due to risks of fetal injury and death. If pregnancy is detected, discontinue Celipress as soon as possible. It is not known whether Celipress is excreted in human milk, but due to the potential for adverse effects on the nursing infant, a decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture.
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Patent Protected
Clinical Trials
Phase III clinical trials demonstrated significant blood pressure reduction and favorable safety profile in patients with essential hypertension. Post-marketing surveillance is ongoing to gather further long-term safety and efficacy data.
Lab Monitoring
- Serum creatinine and blood urea nitrogen (BUN) levels (periodically, especially in patients with renal impairment)
- Serum potassium levels (periodically, especially in patients taking potassium-sparing diuretics or potassium supplements)
- Liver function tests (if signs of hepatic dysfunction appear)
Doctor Notes
- Patients should be counseled on the importance of consistent medication adherence and regular blood pressure monitoring.
- Caution is advised in patients with severe congestive heart failure, bilateral renal artery stenosis, or those on diuretics, as acute renal failure may occur.
- Monitor serum potassium and renal function, especially in elderly patients or those with pre-existing renal impairment.
Patient Guidelines
- Take Celipress exactly as prescribed by your doctor, preferably at the same time each day.
- Do not stop taking the medication without consulting your doctor, even if you feel well.
- Report any signs of swelling of the face, lips, tongue, or throat (angioedema) immediately to your doctor.
Missed Dose Advice
If a dose of Celipress is missed, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Celipress may cause dizziness or lightheadedness, especially at the beginning of treatment or when changing doses. Patients should be cautious when driving or operating machinery until they know how the medication affects them.
Lifestyle Advice
- Adopt a healthy lifestyle including a balanced diet low in sodium and saturated fats.
- Engage in regular physical activity as advised by your doctor.
- Limit alcohol consumption and avoid smoking.
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