Celozin
Generic Name
Levocetirizine
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| celozin 10 mg tablet | ৳ 2.50 | N/A |
Description
Overview of the medicine
Celozin 10 mg Tablet contains Levocetirizine, an antihistamine used to relieve symptoms of allergic conditions such as hay fever, perennial allergic rhinitis, and chronic urticaria. It works by blocking histamine, a natural substance that the body produces during an allergic reaction.
Uses & Indications
Dosage
Adults
10 mg once daily, preferably in the evening. Some patients may respond to 5 mg once daily.
Elderly
Adjustment may be needed in elderly patients with impaired renal function. Consult a doctor.
Renal_impairment
Dose adjustment required based on creatinine clearance. For CrCl 30-49 mL/min: 5 mg every other day; For CrCl <30 mL/min: 5 mg twice weekly. Contraindicated in end-stage renal disease (CrCl <10 mL/min).
How to Take
Take the tablet orally with or without food. It is recommended to take it in the evening to mitigate potential drowsiness.
Mechanism of Action
Levocetirizine is a potent and selective antagonist of peripheral H1-receptors. It blocks the effects of histamine, reducing symptoms like itching, sneezing, watery eyes, and runny nose associated with allergic reactions.
Pharmacokinetics
Onset
Within 15-30 minutes
Excretion
Primarily via urine (approximately 85% of the dose) and feces (approximately 13% of the dose).
Half life
Approximately 7-10 hours
Absorption
Rapidly and extensively absorbed after oral administration, with peak plasma concentrations reached within 1 hour.
Metabolism
Minimally metabolized in the liver (less than 14% of the dose), primarily excreted unchanged.
Side Effects
Contraindications
- Hypersensitivity to levocetirizine or any component of the formulation
- End-stage renal disease (CrCl <10 mL/min)
- Patients undergoing hemodialysis
- Children less than 6 years of age
Drug Interactions
Ritonavir
May increase levocetirizine exposure, though clinical significance is usually minimal.
Theophylline
Small decrease in levocetirizine clearance observed, but clinical significance unknown. No dose adjustment is typically required.
Alcohol and CNS depressants
May increase CNS depression and impair alertness; concomitant use should be avoided.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness in adults and agitation/restlessness followed by drowsiness in children. In case of overdose, seek immediate medical attention. Treatment is symptomatic and supportive. Gastric lavage may be considered if ingestion is recent.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use only if clearly needed after consulting a doctor. Levocetirizine is excreted in breast milk, so caution advised during lactation; a doctor's advice should be sought.
Side Effects
Contraindications
- Hypersensitivity to levocetirizine or any component of the formulation
- End-stage renal disease (CrCl <10 mL/min)
- Patients undergoing hemodialysis
- Children less than 6 years of age
Drug Interactions
Ritonavir
May increase levocetirizine exposure, though clinical significance is usually minimal.
Theophylline
Small decrease in levocetirizine clearance observed, but clinical significance unknown. No dose adjustment is typically required.
Alcohol and CNS depressants
May increase CNS depression and impair alertness; concomitant use should be avoided.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness in adults and agitation/restlessness followed by drowsiness in children. In case of overdose, seek immediate medical attention. Treatment is symptomatic and supportive. Gastric lavage may be considered if ingestion is recent.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use only if clearly needed after consulting a doctor. Levocetirizine is excreted in breast milk, so caution advised during lactation; a doctor's advice should be sought.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date
Availability
Pharmacies nationwide in Bangladesh
Approval Status
Approved by DGDA
Patent Status
Generic available, likely off-patent
Clinical Trials
Levocetirizine has been extensively studied in numerous clinical trials demonstrating its efficacy and safety in treating seasonal and perennial allergic rhinitis, and chronic idiopathic urticaria. These trials confirm its rapid onset of action and sustained relief of symptoms.
Lab Monitoring
- Renal function (creatinine clearance) should be monitored in elderly patients or patients with known renal impairment to adjust dosage appropriately.
Doctor Notes
- Advise patients about potential for drowsiness, especially when initiating therapy.
- Review renal function in elderly patients and those with kidney impairment to ensure appropriate dose adjustment.
- Can be taken without regard to meals, but recommend evening dosing for better sleep and reduced daytime drowsiness.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor.
- Do not exceed the recommended dose.
- Avoid alcohol while taking this medicine as it may increase drowsiness.
- Inform your doctor about all other medications, supplements, or herbal products you are taking.
- May cause drowsiness or dizziness; use caution when driving or operating machinery until you know how it affects you.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and take your next dose at the regular time. Do not double the dose to make up for a missed one.
Driving Precautions
This medicine may cause drowsiness or dizziness. Avoid driving or operating heavy machinery until you know how it affects you. If you experience significant drowsiness, refrain from such activities.
Lifestyle Advice
- Identify and avoid known allergens to help manage your symptoms effectively.
- Maintain good hydration.
- Ensure adequate sleep to minimize fatigue, especially if experiencing drowsiness from the medication.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in Celozin Brand
Other medicines available under the same brand name
