Celozin
Generic Name
Cetirizine Hydrochloride
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| celozin 5 mg syrup | ৳ 30.00 | N/A |
Description
Overview of the medicine
Celozin 5 mg syrup is an antihistamine used to relieve symptoms of allergies such as sneezing, runny nose, watery eyes, and itching. It contains Cetirizine Hydrochloride, a second-generation H1-receptor antagonist.
Uses & Indications
Dosage
Adults
10 mg (10 ml of syrup) once daily. For some patients, 5 mg (5 ml of syrup) twice daily may be preferred.
Elderly
No dosage adjustment needed for elderly with normal renal function. For renal impairment, dosage should be reduced.
Renal_impairment
Moderate renal impairment (creatinine clearance 31-50 ml/min): 5 mg (5 ml of syrup) once daily. Severe renal impairment (creatinine clearance <31 ml/min): 5 mg (5 ml of syrup) every other day. End-stage renal disease/dialysis patients: Not recommended.
How to Take
Celozin syrup should be taken orally, with or without food. Use a measuring spoon or oral syringe for accurate dosing, especially for children.
Mechanism of Action
Cetirizine selectively inhibits peripheral H1-receptors, thereby preventing the binding of histamine to these receptors and blocking histamine-mediated allergic responses. It has minimal sedative effects due to poor penetration into the central nervous system.
Pharmacokinetics
Onset
Onset of action is typically within 20-60 minutes.
Excretion
Mainly excreted unchanged in the urine (about 70% within 24 hours), with a smaller portion excreted in feces.
Half life
Approximately 8-11 hours in adults; prolonged in children and individuals with renal impairment.
Absorption
Rapidly and extensively absorbed from the gastrointestinal tract after oral administration. Peak plasma concentrations are reached within 1 hour.
Metabolism
Minimal hepatic metabolism; primarily excreted unchanged.
Side Effects
Contraindications
- Hypersensitivity to cetirizine, hydroxyzine, or any component of the formulation.
- Severe renal impairment (creatinine clearance <10 ml/min).
Drug Interactions
Ritonavir
Concurrent use with ritonavir may lead to an increased plasma concentration of cetirizine and/or decreased plasma concentration of ritonavir.
Theophylline
A small decrease in cetirizine clearance has been reported with concurrent use of theophylline (400 mg/day).
Central Nervous System (CNS) Depressants
Concurrent use with alcohol, sedatives, or other CNS depressants may increase drowsiness and impair performance.
Storage
Store below 30°C. Protect from light and moisture. Do not freeze. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, agitation, headache, tachycardia, tremor, urinary retention, and rarely, convulsions. Management is symptomatic and supportive; there is no specific antidote. Gastric lavage and activated charcoal may be considered if ingestion is recent.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use only if clearly needed. Cetirizine is excreted into breast milk; therefore, caution should be exercised when administered to a nursing mother.
Side Effects
Contraindications
- Hypersensitivity to cetirizine, hydroxyzine, or any component of the formulation.
- Severe renal impairment (creatinine clearance <10 ml/min).
Drug Interactions
Ritonavir
Concurrent use with ritonavir may lead to an increased plasma concentration of cetirizine and/or decreased plasma concentration of ritonavir.
Theophylline
A small decrease in cetirizine clearance has been reported with concurrent use of theophylline (400 mg/day).
Central Nervous System (CNS) Depressants
Concurrent use with alcohol, sedatives, or other CNS depressants may increase drowsiness and impair performance.
Storage
Store below 30°C. Protect from light and moisture. Do not freeze. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, agitation, headache, tachycardia, tremor, urinary retention, and rarely, convulsions. Management is symptomatic and supportive; there is no specific antidote. Gastric lavage and activated charcoal may be considered if ingestion is recent.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use only if clearly needed. Cetirizine is excreted into breast milk; therefore, caution should be exercised when administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from the date of manufacture. Check the expiration date on the packaging.
Availability
Pharmacies, hospitals, clinics
Approval Status
Approved by regulatory authorities (e.g., DGDA)
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Cetirizine has undergone extensive clinical trials demonstrating its efficacy and safety for allergic conditions in both adults and pediatric populations.
Lab Monitoring
- No specific routine laboratory monitoring is required for cetirizine. Renal function monitoring may be considered in patients with pre-existing renal impairment.
Doctor Notes
- Counsel patients on potential sedative effects, especially during initial therapy or when co-administered with other CNS depressants.
- Advise parents/caregivers on proper dosing for pediatric patients using the provided measuring device.
Patient Guidelines
- Do not exceed the recommended dose.
- Avoid alcohol consumption as it may increase drowsiness.
- Inform your doctor or pharmacist if you experience any unusual side effects.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Celozin syrup may cause drowsiness or dizziness in some individuals. Patients should be advised to exercise caution when driving or operating machinery until they know how the medication affects them.
Lifestyle Advice
- Identify and avoid triggers for your allergies, such as pollen, dust mites, or pet dander.
- Keep your living environment clean and free from allergens.
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