Cephalor
Generic Name
Cefaclor
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| cephalor 250 mg capsule | ৳ 6.78 | N/A |
| cephalor 125 mg suspension | ৳ 81.50 | N/A |
Description
Overview of the medicine
Cefaclor is a second-generation cephalosporin antibiotic used to treat a wide range of bacterial infections including respiratory tract infections, skin and soft tissue infections, and urinary tract infections.
Uses & Indications
Dosage
Adults
250-500 mg orally every 8 hours. Max 4 g/day.
Elderly
Same as adults; caution in renal impairment, monitor kidney function.
Renal_impairment
Dose adjustment required based on creatinine clearance. For CrCl 10-50 mL/min: normal dose given less frequently. For CrCl < 10 mL/min: half dose given less frequently.
How to Take
Administer orally, with or without food. For better absorption, can be taken on an empty stomach, but if gastrointestinal upset occurs, take with food.
Mechanism of Action
Cefaclor is a bactericidal agent that acts by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs) located inside the bacterial cell wall, thereby inhibiting the third and final stage of bacterial cell wall synthesis.
Pharmacokinetics
Onset
Peak plasma concentrations are generally achieved within 0.5 to 1 hour.
Excretion
Mainly excreted by the kidneys (approximately 60-85% unchanged in urine within 8 hours).
Half life
Approximately 0.6 to 1 hour.
Absorption
Rapidly and well absorbed from the gastrointestinal tract after oral administration.
Metabolism
Minimally metabolized; primarily excreted unchanged.
Side Effects
Contraindications
- Hypersensitivity to cefaclor or other cephalosporins
- History of severe hypersensitivity reactions to penicillin (due to potential cross-reactivity)
Drug Interactions
Warfarin
May enhance the anticoagulant effect of warfarin and other oral anticoagulants.
Probenecid
Increases cefaclor plasma levels and prolongs its half-life by decreasing renal tubular secretion.
Storage
Store in a cool, dry place below 30°C, protected from light and moisture. Keep out of reach of children. Reconstituted suspension should be stored in a refrigerator (2-8°C) and used within 14 days.
Overdose
In case of overdose, seek immediate medical attention. Management should be supportive and symptomatic. Gastric lavage may be indicated if performed within 1-2 hours of ingestion. Hemodialysis is not substantially effective.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus. However, use in pregnancy only if clearly needed. Excreted in breast milk in small amounts; use with caution during lactation.
Side Effects
Contraindications
- Hypersensitivity to cefaclor or other cephalosporins
- History of severe hypersensitivity reactions to penicillin (due to potential cross-reactivity)
Drug Interactions
Warfarin
May enhance the anticoagulant effect of warfarin and other oral anticoagulants.
Probenecid
Increases cefaclor plasma levels and prolongs its half-life by decreasing renal tubular secretion.
Storage
Store in a cool, dry place below 30°C, protected from light and moisture. Keep out of reach of children. Reconstituted suspension should be stored in a refrigerator (2-8°C) and used within 14 days.
Overdose
In case of overdose, seek immediate medical attention. Management should be supportive and symptomatic. Gastric lavage may be indicated if performed within 1-2 hours of ingestion. Hemodialysis is not substantially effective.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus. However, use in pregnancy only if clearly needed. Excreted in breast milk in small amounts; use with caution during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from manufacturing date
Availability
Available in pharmacies and hospitals
Approval Status
DGDA approved
Patent Status
Patent expired
Clinical Trials
Extensive clinical trials have established the efficacy and safety of Cefaclor in treating various bacterial infections. Ongoing post-marketing surveillance continues to monitor its profile.
Lab Monitoring
- Renal function tests (e.g., creatinine, BUN) during prolonged therapy
- Complete blood count (CBC) occasionally, especially during long-term use
Doctor Notes
- Assess renal function before initiating therapy, especially in elderly patients.
- Counsel patients on completing the full course to prevent resistance.
- Monitor for signs of hypersensitivity reactions, especially in penicillin-allergic patients.
Patient Guidelines
- Take the full course of medicine as prescribed, even if symptoms improve.
- Do not skip doses or stop taking the medicine without consulting your doctor.
- Inform your doctor about any unusual side effects or allergic reactions.
Missed Dose Advice
If a dose is missed, take it as soon as remembered. If it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose.
Driving Precautions
Generally considered safe to drive or operate machinery. However, if you experience dizziness or adverse effects that impair concentration, avoid these activities.
Lifestyle Advice
- Stay well-hydrated during treatment by drinking plenty of fluids.
- Maintain good hygiene to prevent further infections.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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