Certican
Generic Name
Everolimus
Manufacturer
Novartis
Country
Switzerland (original developer), manufactured globally
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| certican 050 mg tablet | ৳ 250.00 | ৳ 2,500.00 |
Description
Overview of the medicine
Certican (Everolimus) is an immunosuppressant medicine used to prevent organ rejection in kidney or heart transplant recipients and to treat certain types of cancer and tumors.
Uses & Indications
Dosage
Adults
Kidney transplant: Initial dose 0.75 mg twice daily. Heart transplant: Initial dose 1.5 mg twice daily. Oncology indications: Varies, typically 10 mg once daily. Doses are adjusted based on therapeutic drug monitoring and patient tolerance.
Elderly
No specific dose adjustment is required based on age, but caution is advised due to potential for decreased renal/hepatic function and concomitant diseases.
Renal_impairment
No dose adjustment is required for renal impairment. However, monitor everolimus trough levels.
How to Take
Certican tablets should be taken orally, consistently at the same time each day, either with or without food. They should be swallowed whole with water, not crushed or chewed.
Mechanism of Action
Everolimus is a selective inhibitor of mammalian target of rapamycin (mTOR), a key kinase that regulates cell growth, proliferation, and survival. By inhibiting mTOR, it blocks various cell cycle progression steps, thereby suppressing T-cell activation and proliferation, which are crucial for the immune response.
Pharmacokinetics
Onset
Immunosuppressive effects begin within hours to days, but full therapeutic effect may take longer.
Excretion
Primarily excreted in feces (approximately 80%), with a small amount excreted in urine (approximately 5%).
Half life
Approximately 28-35 hours (mean).
Absorption
Rapidly absorbed after oral administration, peak concentrations reached within 1-2 hours. Bioavailability is dose-dependent.
Metabolism
Extensively metabolized in the liver and intestinal wall by CYP3A4.
Side Effects
Contraindications
- •Hypersensitivity to everolimus or to other rapamycin derivatives (sirolimus) or to any of the excipients.
- •Patients with severe hepatic impairment without dose adjustment.
Drug Interactions
Live Vaccines
Avoid during everolimus therapy due to increased risk of infection.
CYP3A4 Inducers (e.g., Rifampicin, Carbamazepine, Phenobarbital, Phenytoin, St. John's wort)
Can significantly decrease everolimus blood concentrations, potentially leading to reduced efficacy. Dose increase may be necessary.
CYP3A4 Inhibitors (e.g., Ketoconazole, Itraconazole, Erythromycin, Clarithromycin, Ritonavir, Grapefruit juice)
Can significantly increase everolimus blood concentrations, leading to increased risk of adverse effects. Dose reduction may be necessary.
Storage
Store below 30°C. Protect from moisture and light. Keep out of reach of children. Do not remove from blister pack until immediately before use.
Overdose
Limited experience with overdose. In cases of overdose, general supportive measures should be initiated. Monitor everolimus trough blood concentrations.
Pregnancy & Lactation
Pregnancy Category C. Everolimus may cause fetal harm. Should not be used during pregnancy unless the potential benefit justifies the potential risk to the fetus. Women of childbearing potential should use effective contraception during treatment and for 8 weeks after the last dose. It is not known whether everolimus is excreted in human milk, but due to the potential for serious adverse reactions in nursing infants, breastfeeding is not recommended.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from the date of manufacture, specific details on packaging.
Availability
Hospitals, retail pharmacies specializing in transplant/oncology medicines
Approval Status
Approved (e.g., FDA, EMA, DGDA)
Patent Status
Patent expired for generic, brand may still have some protection
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Global Brand Names
International brand names for this medicine
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