Cetriben
Generic Name
Cetirizine Hydrochloride
Manufacturer
XYZ Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| cetriben 10 mg tablet | ৳ 3.00 | ৳ 30.00 |
Description
Overview of the medicine
Cetriben 10 mg Tablet contains Cetirizine, a second-generation antihistamine used to relieve symptoms of seasonal and perennial allergic rhinitis and chronic idiopathic urticaria.
Uses & Indications
Dosage
Adults
10 mg once daily or 5 mg twice daily.
Elderly
5 mg once daily, or as directed by a physician. Dose adjustment may be necessary for elderly patients with impaired renal function.
Renal_impairment
Adults with CrCl 31-60 mL/min: 5 mg once daily. Adults with CrCl 11-30 mL/min: 5 mg every other day. Adults with CrCl <10 mL/min: Contraindicated.
How to Take
Take Cetriben 10 mg Tablet orally with or without food. Swallow the tablet whole with a glass of water. Do not crush or chew.
Mechanism of Action
Cetirizine selectively inhibits peripheral H1-receptors, thereby blocking the effects of histamine, which is responsible for allergic symptoms like sneezing, itching, and watery eyes. It also inhibits the migration of inflammatory cells and the release of mediators from mast cells.
Pharmacokinetics
Onset
Within 20-60 minutes.
Excretion
Primarily excreted unchanged in the urine (approximately 60%) and feces (approximately 10%).
Half life
Approximately 8-10 hours in adults.
Absorption
Rapidly absorbed after oral administration, peak plasma concentrations reached within 1 hour.
Metabolism
Minimal hepatic metabolism, about 10% of the dose is metabolized.
Side Effects
Contraindications
- Hypersensitivity to cetirizine, hydroxyzine, or any piperazine derivatives.
- Patients with severe renal impairment (creatinine clearance less than 10 mL/min).
Drug Interactions
Ritonavir
May increase cetirizine exposure, consult a doctor.
CNS Depressants (e.g., alcohol, sedatives)
Concomitant use may enhance central nervous system depression, leading to increased drowsiness or impaired psychomotor performance. Avoid alcohol consumption.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, tachycardia, tremor, headache, and urinary retention. In case of overdose, seek immediate medical attention. Management is symptomatic and supportive; there is no specific antidote.
Pregnancy & Lactation
Pregnancy Category B. Cetirizine should be used during pregnancy only if clearly needed. It is excreted into breast milk; therefore, caution should be exercised when administered to a nursing mother. Consult a doctor.
Side Effects
Contraindications
- Hypersensitivity to cetirizine, hydroxyzine, or any piperazine derivatives.
- Patients with severe renal impairment (creatinine clearance less than 10 mL/min).
Drug Interactions
Ritonavir
May increase cetirizine exposure, consult a doctor.
CNS Depressants (e.g., alcohol, sedatives)
Concomitant use may enhance central nervous system depression, leading to increased drowsiness or impaired psychomotor performance. Avoid alcohol consumption.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, tachycardia, tremor, headache, and urinary retention. In case of overdose, seek immediate medical attention. Management is symptomatic and supportive; there is no specific antidote.
Pregnancy & Lactation
Pregnancy Category B. Cetirizine should be used during pregnancy only if clearly needed. It is excreted into breast milk; therefore, caution should be exercised when administered to a nursing mother. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date
Availability
Available in pharmacies nationwide
Approval Status
Approved (e.g., FDA/DGDA)
Patent Status
Expired
Clinical Trials
Extensive clinical trials have demonstrated cetirizine's efficacy and safety in treating allergic rhinitis and urticaria, showing superior efficacy to placebo and comparable to other second-generation antihistamines with a favorable safety profile.
Lab Monitoring
- No routine lab monitoring is generally required. Renal function may need monitoring in elderly or renally impaired patients.
Doctor Notes
- Counsel patients on potential mild drowsiness, especially at the start of therapy.
- Advise against concurrent alcohol use due to enhanced CNS depression.
- Emphasize renal dose adjustment in elderly and renally impaired patients.
Patient Guidelines
- Take exactly as prescribed by your doctor.
- Do not exceed the recommended dose.
- Avoid alcohol and other CNS depressants while taking this medication as it may increase drowsiness.
- Inform your doctor if symptoms do not improve or worsen.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and take your next dose at the regular time. Do not double the dose.
Driving Precautions
Cetirizine may cause drowsiness or dizziness in some individuals. Exercise caution when driving or operating machinery until you know how the medication affects you.
Lifestyle Advice
- Identify and avoid known allergens. Keep your home dust-free. Use air purifiers if necessary.
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