Cetriben
Generic Name
Cetirizine 5 mg/5 ml Syrup
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| cetriben 5 mg syrup | ৳ 35.00 | N/A |
Description
Overview of the medicine
Cetriben 5 mg/5 ml Syrup contains Cetirizine, a second-generation antihistamine used to relieve symptoms of allergies such as runny nose, sneezing, itching, watery eyes, and hives. It works by blocking histamine, a natural substance that the body produces during an allergic reaction.
Uses & Indications
Dosage
Adults
10 ml (10 mg) once daily, or 5 ml (5 mg) twice daily. Max 10 ml/day. For mild symptoms, 5 ml (5 mg) once daily may be sufficient. For children 6-12 years: 5 ml (5 mg) twice daily or 10 ml (10 mg) once daily. For children 2-6 years: 2.5 ml (2.5 mg) twice daily or 5 ml (5 mg) once daily. For children 6 months-2 years: 2.5 ml (2.5 mg) once daily.
Elderly
5 ml (5 mg) once daily. Dosage adjustment may be necessary for renal impairment.
Renal_impairment
For moderate renal impairment (CrCl 31-50 ml/min), 5 ml (5 mg) once daily. For severe renal impairment (CrCl < 30 ml/min), 5 ml (5 mg) every other day.
How to Take
Cetriben syrup should be taken orally, with or without food. Use a measuring spoon or oral syringe to ensure accurate dosing, especially for children.
Mechanism of Action
Cetirizine is a potent and selective antagonist of peripheral H1-receptors. It blocks the binding of histamine to these receptors, thereby preventing the release of inflammatory mediators and reducing allergic symptoms like itching, sneezing, and vasodilation.
Pharmacokinetics
Onset
Within 20 to 60 minutes.
Excretion
Primarily excreted unchanged in the urine (about 70%) and about 10% in feces.
Half life
Approximately 8-11 hours (adults), 6 hours (children 6-12 years), 5 hours (children 2-6 years), 3.5 hours (children 6 months-2 years).
Absorption
Rapidly and extensively absorbed from the gastrointestinal tract after oral administration. Peak plasma concentrations are achieved within 1 hour.
Metabolism
Undergoes limited hepatic metabolism; approximately 10% of the dose is metabolized.
Side Effects
Contraindications
- Hypersensitivity to cetirizine, hydroxyzine, or any piperazine derivatives
- Severe renal impairment (CrCl < 10 ml/min) without dose adjustment
Drug Interactions
CNS depressants (e.g., alcohol, sedatives)
Concurrent use may enhance CNS depression, including drowsiness and impaired performance. Caution is advised.
Storage
Store below 30°C. Protect from light and moisture. Keep out of reach of children. Do not freeze.
Overdose
Symptoms of overdose may include drowsiness, sedation, tachycardia, urinary retention, and tremor. In children, agitation may be observed. Treatment is symptomatic and supportive; gastric lavage may be considered if ingestion is recent. There is no specific antidote.
Pregnancy & Lactation
Pregnancy: Category B. Studies in animals have shown no evidence of harm to the fetus. Use during pregnancy only if clearly needed. Lactation: Cetirizine is excreted in breast milk. Use with caution in nursing mothers; consider alternatives or monitor infant for sedation.
Side Effects
Contraindications
- Hypersensitivity to cetirizine, hydroxyzine, or any piperazine derivatives
- Severe renal impairment (CrCl < 10 ml/min) without dose adjustment
Drug Interactions
CNS depressants (e.g., alcohol, sedatives)
Concurrent use may enhance CNS depression, including drowsiness and impaired performance. Caution is advised.
Storage
Store below 30°C. Protect from light and moisture. Keep out of reach of children. Do not freeze.
Overdose
Symptoms of overdose may include drowsiness, sedation, tachycardia, urinary retention, and tremor. In children, agitation may be observed. Treatment is symptomatic and supportive; gastric lavage may be considered if ingestion is recent. There is no specific antidote.
Pregnancy & Lactation
Pregnancy: Category B. Studies in animals have shown no evidence of harm to the fetus. Use during pregnancy only if clearly needed. Lactation: Cetirizine is excreted in breast milk. Use with caution in nursing mothers; consider alternatives or monitor infant for sedation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Usually 24-36 months from the manufacturing date when stored under recommended conditions.
Availability
Pharmacies, drugstores
Approval Status
Approved by major regulatory bodies globally (e.g., FDA, DGDA)
Patent Status
Generic available, original patent expired
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established cetirizine's efficacy and safety in treating various allergic conditions, demonstrating rapid onset of action and sustained symptom relief with a favorable side effect profile.
Lab Monitoring
- No routine lab monitoring is generally required for cetirizine. Renal function may be monitored in patients with pre-existing renal impairment.
Doctor Notes
- Advise patients about potential drowsiness and to avoid activities requiring mental alertness until individual response is known.
- Consider lower doses in elderly patients or those with renal/hepatic impairment.
- Counsel parents on accurate dosing using appropriate measuring devices for pediatric patients.
Patient Guidelines
- Do not exceed the recommended dose.
- Be cautious when driving or operating machinery, as it may cause drowsiness.
- Avoid alcohol consumption while taking this medication.
- Inform your doctor about all other medications you are taking.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Cetirizine may cause drowsiness or dizziness in some individuals. Patients should be advised to exercise caution when driving or operating hazardous machinery until they know how they react to the medication.
Lifestyle Advice
- Identify and avoid known allergens to minimize allergic reactions.
- Keep hydrated, especially if experiencing dry mouth.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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