Cilmedip
Generic Name
Cilnidipine
Manufacturer
Medex Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| cilmedip 5 mg tablet | ৳ 4.00 | ৳ 40.00 |
| cilmedip 10 mg tablet | ৳ 6.00 | ৳ 60.00 |
Description
Overview of the medicine
Cilnidipine is a dihydropyridine calcium channel blocker used in the management of essential hypertension. It blocks both L-type and N-type voltage-dependent calcium channels.
Uses & Indications
Dosage
Adults
The usual initial dose is 5 mg or 10 mg once daily. The dose may be increased up to a maximum of 20 mg once daily, depending on the patient's response and tolerance.
Elderly
Initiate treatment with a lower dose, such as 5 mg once daily, and titrate carefully based on response.
Renal_impairment
No dose adjustment is usually required for mild to moderate renal impairment. Use with caution in severe renal impairment.
How to Take
Cilmedip tablets should be taken orally, with or without food, preferably at the same time each day.
Mechanism of Action
Cilnidipine inhibits the influx of calcium ions into vascular smooth muscle cells by blocking L-type voltage-gated calcium channels, leading to vasodilation. Additionally, it blocks N-type calcium channels in sympathetic nerve endings, which may reduce sympathetic overactivity and lower heart rate.
Pharmacokinetics
Onset
Onset of antihypertensive action within 1-2 hours.
Excretion
Primarily excreted in feces (about 60%) and urine (about 40%) as metabolites.
Half life
Elimination half-life is approximately 5-10 hours.
Absorption
Well absorbed after oral administration, with peak plasma concentrations reached in 1.5-3 hours.
Metabolism
Extensively metabolized in the liver primarily by cytochrome P450 3A4 (CYP3A4).
Side Effects
Contraindications
- Hypersensitivity to Cilnidipine or other dihydropyridine calcium channel blockers
- Cardiogenic shock
- Severe aortic stenosis
- Unstable angina pectoris
Drug Interactions
Other Antihypertensives
Concomitant use may lead to additive hypotensive effects.
CYP3A4 Inducers (e.g., Rifampicin, Carbamazepine)
May decrease plasma concentrations of Cilnidipine, reducing its efficacy.
CYP3A4 Inhibitors (e.g., Ketoconazole, Erythromycin)
May increase plasma concentrations of Cilnidipine, leading to increased hypotensive effect.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include excessive peripheral vasodilation with marked hypotension, bradycardia, and possibly shock. Management should involve supportive care, including monitoring of vital signs, fluid replacement, and if necessary, vasopressors.
Pregnancy & Lactation
Pregnancy Category C. Cilnidipine should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is unknown whether Cilnidipine is excreted in human milk, so caution should be exercised when administered to a nursing mother.
Side Effects
Contraindications
- Hypersensitivity to Cilnidipine or other dihydropyridine calcium channel blockers
- Cardiogenic shock
- Severe aortic stenosis
- Unstable angina pectoris
Drug Interactions
Other Antihypertensives
Concomitant use may lead to additive hypotensive effects.
CYP3A4 Inducers (e.g., Rifampicin, Carbamazepine)
May decrease plasma concentrations of Cilnidipine, reducing its efficacy.
CYP3A4 Inhibitors (e.g., Ketoconazole, Erythromycin)
May increase plasma concentrations of Cilnidipine, leading to increased hypotensive effect.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include excessive peripheral vasodilation with marked hypotension, bradycardia, and possibly shock. Management should involve supportive care, including monitoring of vital signs, fluid replacement, and if necessary, vasopressors.
Pregnancy & Lactation
Pregnancy Category C. Cilnidipine should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is unknown whether Cilnidipine is excreted in human milk, so caution should be exercised when administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months from manufacturing date.
Availability
Available in pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Off-patent
Clinical Trials
Numerous clinical trials have demonstrated the efficacy and safety of Cilnidipine in managing hypertension, including studies comparing its effects to other calcium channel blockers and its benefits in specific patient populations.
Lab Monitoring
- Regular monitoring of blood pressure and heart rate is recommended. Routine liver function tests may be considered in patients with pre-existing hepatic impairment or during long-term therapy.
Doctor Notes
- Emphasize patient compliance for optimal blood pressure control.
- Monitor for peripheral edema, although less common with Cilnidipine.
- Consider its renoprotective effects, especially in diabetic hypertensive patients.
Patient Guidelines
- Take the medicine regularly as prescribed by your doctor.
- Do not stop taking Cilmedip suddenly without consulting your doctor.
- Report any unusual side effects to your healthcare provider.
Missed Dose Advice
If a dose is missed, take it as soon as remembered. If it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose to make up for a missed one.
Driving Precautions
Cilnidipine may cause dizziness or lightheadedness, especially at the start of treatment or when the dose is increased. Patients should be advised to exercise caution when driving or operating machinery.
Lifestyle Advice
- Maintain a healthy lifestyle, including a balanced diet low in sodium and regular exercise.
- Avoid smoking and limit alcohol consumption.
- Regularly monitor your blood pressure at home if advised by your doctor.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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